02502nas a2200241   4500008004100000245014200041210006900183260001200252300000900264490000700273520173500280653002502015653001702040653000902057653003202066100001702098700002102115700001702136700002002153700002002173700001802193856004902211       2018                        eng d00aThe associations of subclinical atherosclerotic cardiovascular disease with hip fracture risk and bone mineral density in elderly adults.0 aassociations of subclinical atherosclerotic cardiovascular disea  c08/2018  a22300 v293 aIn the absence of clinically recognized cardiovascular disease, increased carotid artery intimal medial thickness was associated with higher hip fracture risk in older adults, despite its association with higher bone mineral density (BMD). Low ankle brachial index and aortic wall thickness were not associated with fracture risk or BMD.
INTRODUCTION:

Clinically recognized cardiovascular disease (CVD) is associated with osteoporosis and hip fracture risk, but the relationship of subclinical atherosclerosis to bone health is not certain.
METHODS:

We followed 3385 participants from the Cardiovascular Health Study (mean age 74.7 ± 5.3 years) with a median time to fracture of 12.1 years who underwent baseline carotid artery and aortic wall ultrasound scanning and ankle brachial blood pressure index (ABI) determinations. A subset underwent bone mineral density (BMD) testing.
RESULTS:

There were 494 hip fractures during follow-up. Among persons without clinical CVD, an average standard-deviation increase in a composite score of maximal common and internal carotid artery intimal medial thickness (cIMT) was associated with increased risk of hip fracture [(HR 1.18 [1.04, 1.35]), even though cIMT was positively associated with BMD. Neither aortic wall thickness nor ABI were associated with hip fracture risk or BMD. Among participants with clinical CVD, cIMT and aortic wall thickness, but not ABI, were associated with increased hip fracture risk.
CONCLUSION:

Subclinical cIMT is associated with an increased risk of hip fractures despite being associated with increased BMD. This finding suggests that vascular health, even in its early stages, is linked to bone health, by pathways other than BMD.10aBone mineral density10aHip fracture10aRisk10aSubclinical atherosclerosis1 aBarzilay, JI1 aBůzková, Petra1 aCauley, J, A1 aRobbins, J., A.1 aFink, Howard, A1 aMukamal, K, J  uhttps://www.ncbi.nlm.nih.gov/pubmed/30132027