04406nas a2201225 4500008004100000022001400041245011600055210006900171260001600240300000900256490000600265520095200271100002001223700002001243700001701263700001601280700002601296700001901322700002201341700001901363700002501382700001701407700001801424700002201442700001901464700002001483700001801503700002501521700002501546700002301571700001901594700002301613700001601636700001601652700002801668700002001696700002101716700002101737700001801758700001901776700001601795700001801811700002001829700002401849700001801873700002101891700002501912700002601937700002601963700002401989700002202013700001802035700002202053700001802075700001902093700001302112700002102125700002002146700002202166700002302188700002102211700002202232700002102254700002002275700002102295700002502316700002002341700002002361700001402381700002202395700001902417700002602436700002202462700002402484700002502508700002002533700002002553700002602573700002802599700003302627700002302660700001302683700001702696700002002713700002402733700002402757700001902781700002202800700002302822700002202845700001902867700001802886700002302904700002002927700002602947700002102973700002502994700002003019700002303039700002203062700002003084700002003104700002003124856003603144 2018 eng d a2041-172300aGenome-wide association study of 23,500 individuals identifies 7 loci associated with brain ventricular volume.0 aGenomewide association study of 23500 individuals identifies 7 l c2018 Sep 26 a39450 v93 a
The volume of the lateral ventricles (LV) increases with age and their abnormal enlargement is a key feature of several neurological and psychiatric diseases. Although lateral ventricular volume is heritable, a comprehensive investigation of its genetic determinants is lacking. In this meta-analysis of genome-wide association studies of 23,533 healthy middle-aged to elderly individuals from 26 population-based cohorts, we identify 7 genetic loci associated with LV volume. These loci map to chromosomes 3q28, 7p22.3, 10p12.31, 11q23.1, 12q23.3, 16q24.2, and 22q13.1 and implicate pathways related to tau pathology, S1P signaling, and cytoskeleton organization. We also report a significant genetic overlap between the thalamus and LV volumes (ρ = -0.59, p-value = 3.14 × 10), suggesting that these brain structures may share a common biology. These genetic associations of LV volume provide insights into brain morphology.
1 aVojinovic, Dina1 aAdams, Hieab, H1 aJian, Xueqiu1 aYang, Qiong1 aSmith, Albert, Vernon1 aBis, Joshua, C1 aTeumer, Alexander1 aScholz, Markus1 aArmstrong, Nicola, J1 aHofer, Edith1 aSaba, Yasaman1 aLuciano, Michelle1 aBernard, Manon1 aTrompet, Stella1 aYang, Jingyun1 aGillespie, Nathan, A1 avan der Lee, Sven, J1 aNeumann, Alexander1 aAhmad, Shahzad1 aAndreassen, Ole, A1 aAmes, David1 aAmin, Najaf1 aArfanakis, Konstantinos1 aBastin, Mark, E1 aBecker, Diane, M1 aBeiser, Alexa, S1 aBeyer, Frauke1 aBrodaty, Henry1 aBryan, Nick1 aBülow, Robin1 aDale, Anders, M1 aDe Jager, Philip, L1 aDeary, Ian, J1 aDeCarli, Charles1 aFleischman, Debra, A1 aGottesman, Rebecca, F1 avan der Grond, Jeroen1 aGudnason, Vilmundur1 aHarris, Tamara, B1 aHomuth, Georg1 aKnopman, David, S1 aKwok, John, B1 aLewis, Cora, E1 aLi, Shuo1 aLoeffler, Markus1 aLopez, Oscar, L1 aMaillard, Pauline1 aMarroun, Hanan, El1 aMather, Karen, A1 aMosley, Thomas, H1 aMuetzel, Ryan, L1 aNauck, Matthias1 aNyquist, Paul, A1 aPanizzon, Matthew, S1 aPausova, Zdenka1 aPsaty, Bruce, M1 aRice, Ken1 aRotter, Jerome, I1 aRoyle, Natalie1 aSatizabal, Claudia, L1 aSchmidt, Reinhold1 aSchofield, Peter, R1 aSchreiner, Pamela, J1 aSidney, Stephen1 aStott, David, J1 aThalamuthu, Anbupalam1 aUitterlinden, André, G1 aHernández, Maria, C Valdés1 aVernooij, Meike, W1 aWen, Wei1 aWhite, Tonya1 aWitte, Veronica1 aWittfeld, Katharina1 aWright, Margaret, J1 aYanek, Lisa, R1 aTiemeier, Henning1 aKremen, William, S1 aBennett, David, A1 aJukema, Wouter1 aPaus, Tomáš1 aWardlaw, Joanna, M1 aSchmidt, Helena1 aSachdev, Perminder, S1 aVillringer, Arno1 aGrabe, Hans, Jörgen1 aLongstreth, W T1 aDuijn, Cornelia, M1 aLauner, Lenore, J1 aSeshadri, Sudha1 aIkram, Arfan, M1 aFornage, Myriam uhttps://chs-nhlbi.org/node/7849