02364nas a2200229 4500008004100000022001400041245010200055210006900157260001600226300001400242490000700256520160700263100002401870700002101894700002101915700002801936700002001964700002301984700002002007710007102027856003602098 2019 eng d a1526-632X00aSerum magnesium and calcium levels in relation to ischemic stroke: Mendelian randomization study.0 aSerum magnesium and calcium levels in relation to ischemic strok c2019 Feb 26 ae944-e9500 v923 a

OBJECTIVE: To determine whether serum magnesium and calcium concentrations are causally associated with ischemic stroke or any of its subtypes using the mendelian randomization approach.

METHODS: Analyses were conducted using summary statistics data for 13 single-nucleotide polymorphisms robustly associated with serum magnesium (n = 6) or serum calcium (n = 7) concentrations. The corresponding data for ischemic stroke were obtained from the MEGASTROKE consortium (34,217 cases and 404,630 noncases).

RESULTS: In standard mendelian randomization analysis, the odds ratios for each 0.1 mmol/L (about 1 SD) increase in genetically predicted serum magnesium concentrations were 0.78 (95% confidence interval [CI] 0.69-0.89; = 1.3 × 10) for all ischemic stroke, 0.63 (95% CI 0.50-0.80; = 1.6 × 10) for cardioembolic stroke, and 0.60 (95% CI 0.44-0.82; = 0.001) for large artery stroke; there was no association with small vessel stroke (odds ratio 0.90, 95% CI 0.67-1.20; = 0.46). Only the association with cardioembolic stroke was robust in sensitivity analyses. There was no association of genetically predicted serum calcium concentrations with all ischemic stroke (per 0.5 mg/dL [about 1 SD] increase in serum calcium: odds ratio 1.03, 95% CI 0.88-1.21) or with any subtype.

CONCLUSIONS: This study found that genetically higher serum magnesium concentrations are associated with a reduced risk of cardioembolic stroke but found no significant association of genetically higher serum calcium concentrations with any ischemic stroke subtype.

1 aLarsson, Susanna, C1 aTraylor, Matthew1 aBurgess, Stephen1 aBoncoraglio, Giorgio, B1 aJern, Christina1 aMichaëlsson, Karl1 aMarkus, Hugh, S1 aMEGASTROKE project of the International Stroke Genetics Consortium uhttps://chs-nhlbi.org/node/7978