01783nas a2200193 4500008004100000022001400041245016700055210006900222260000900291300001200300490000700312520108800319100002001407700002501427700002401452700002001476710005701496856003601553 2018 eng d a2352-872900aGenetically elevated high-density lipoprotein cholesterol through the cholesteryl ester transfer protein gene does not associate with risk of Alzheimer's disease.0 aGenetically elevated highdensity lipoprotein cholesterol through c2018 a595-5980 v103 a

Introduction: There is conflicting evidence whether high-density lipoprotein cholesterol (HDL-C) is a risk factor for Alzheimer's disease (AD) and dementia. Genetic variation in the cholesteryl ester transfer protein () locus is associated with altered HDL-C. We aimed to assess AD risk by genetically predicted HDL-C.

Methods: Ten single nucleotide polymorphisms within the locus predicting HDL-C were applied to the International Genomics of Alzheimer's Project (IGAP) exome chip stage 1 results in up 16,097 late onset AD cases and 18,077 cognitively normal elderly controls. We performed instrumental variables analysis using inverse variance weighting, weighted median, and MR-Egger.

Results: Based on 10 single nucleotide polymorphisms distinctly predicting HDL-C in the locus, we found that HDL-C was not associated with risk of AD ( > .7).

Discussion: Our study does not support the role of HDL-C on risk of AD through HDL-C altered by . This study does not rule out other mechanisms by which HDL-C affects risk of AD.

1 aPeloso, Gina, M1 avan der Lee, Sven, J1 aDeStefano, Anita, L1 aSeshardi, Sudha1 aInternational Genomics of Alzheimer's Project (IGAP) uhttps://chs-nhlbi.org/node/7987