03855nas a2200481 4500008004100000022001400041245015500055210006900210260001300279300001000292490000800302520246000310653000902770653002202779653001502801653001902816653002802835653002102863653002802884653002802912653001302940653001102953653001502964653001102979653001702990653001903007653000903026653002703035653001603062653001903078653002703097653001703124100002003141700002803161700001803189700001903207700002103226700002403247700002203271700002403293700002103317856003503338 2005 eng d a1549-471300aCardiovascular risk factors for retinal vein occlusion and arteriolar emboli: the Atherosclerosis Risk in Communities & Cardiovascular Health studies.0 aCardiovascular risk factors for retinal vein occlusion and arter c2005 Apr a540-70 v1123 a

OBJECTIVE: To examine the associations of retinal vein occlusion and arteriolar emboli with cardiovascular disease.

DESIGN: Population-based cross-sectional study.

PARTICIPANTS: Pooled from the Atherosclerosis Risk in Communities Study (n = 12,642; mean age, 60 years) and the Cardiovascular Health Study (n = 2824; mean age, 79 years).

METHODS: Retinal vein occlusion and arteriolar emboli were identified from a single nonmydriatic retinal photograph using a standardized protocol. Photographs were also graded for arteriovenous nicking and focal arteriolar narrowing. All participants had a comprehensive systemic evaluation, including standardized carotid ultrasonography.

MAIN OUTCOME MEASURES: Retinal vein occlusion and arteriolar emboli.

RESULTS: Prevalences of retinal vein occlusion and arteriolar emboli were 0.3% (n = 39 cases) and 0.2% (n = 34 cases), respectively. After adjusting for age, retinal vein occlusion was associated with hypertension (odds ratio [OR], 2.96; 95% confidence interval [CI], 1.43-6.14), systolic blood pressure (BP) (OR, 4.12; 95% CI, 1.40-12.16; highest quartile vs. lowest), diastolic BP (OR, 2.64; 95% CI, 1.07-6.46; highest quartile vs. lowest), carotid artery plaque (OR, 5.62; 95% CI, 2.60-12.16), body mass index (OR, 3.88; 95% CI, 1.23-12.18; highest quartile vs. lowest), plasma fibrinogen (OR, 3.29; 95% CI, 1.08-10.02; highest quartile vs. lowest), arteriovenous nicking (OR, 4.09; 95% CI, 2.00-8.36), and focal arteriolar narrowing (OR, 5.17; 95% CI, 2.59-10.29). After adjusting for age, retinal arteriolar emboli were associated with hypertension (OR, 3.14; 95% CI, 1.44-6.84), systolic BP (OR, 3.46; 95% CI, 1.13-10.65; highest quartile vs. lowest), prevalent coronary heart disease (OR, 2.33; 95% CI, 1.01-5.42), carotid artery plaque (OR, 4.62; 95% CI, 1.85-11.57), plasma lipoprotein (a) (OR, 3.69; 95% CI, 1.20-11.41; highest quartile vs. lowest), plasma fibrinogen (OR, 3.09; 95% CI, 0.98-9.76; highest quartile vs. lowest), and current cigarette smoking (OR, 3.08; 95% CI, 1.47-6.47). Approximately a quarter of participants with retinal vein occlusion and arteriolar emboli had evidence of carotid artery plaque as defined from ultrasound.

CONCLUSIONS: Retinal vein occlusion and retinal arteriolar emboli are associated with carotid artery disease, hypertension, and other cardiovascular risk factors.

10aAged10aAged, 80 and over10aArterioles10aBlood Pressure10aCardiovascular Diseases10aCarotid Stenosis10aCoronary Artery Disease10aCross-Sectional Studies10aEmbolism10aFemale10aFibrinogen10aHumans10aHypertension10aLipoprotein(a)10aMale10aMeta-Analysis as Topic10aMiddle Aged10aRetinal Artery10aRetinal Vein Occlusion10aRisk Factors1 aWong, Tien, Yin1 aLarsen, Emily, K Marino1 aKlein, Ronald1 aMitchell, Paul1 aCouper, David, J1 aKlein, Barbara, E K1 aHubbard, Larry, D1 aSiscovick, David, S1 aSharrett, Richey uhttps://chs-nhlbi.org/node/826