02929nas a2200289 4500008004100000022001400041245011200055210006900167260001600236300001200252490000600264520204600270100002602316700002002342700002302362700002002385700001902405700002402424700002502448700002002473700001702493700002802510700002302538700002402561700001802585856003602603 2020 eng d a2574-380500aAssociation of Leukocyte Telomere Length With Mortality Among Adult Participants in 3 Longitudinal Studies.0 aAssociation of Leukocyte Telomere Length With Mortality Among Ad c2020 Feb 05 ae2000230 v33 a

Importance: Leukocyte telomere length (LTL) is a trait associated with risk of cardiovascular disease and cancer, the 2 major disease categories that largely define longevity in the United States. However, it remains unclear whether LTL is associated with the human life span.

Objective: To examine whether LTL is associated with the life span of contemporary humans.

Design, Setting, and Participants: This cohort study included 3259 adults of European ancestry from the Cardiovascular Health Study (CHS), Framingham Heart Study (FHS), and Women's Health Initiative (WHI). Leukocyte telomere length was measured in 1992 and 1997 in the CHS, from 1995 to 1998 in the FHS, and from 1993 to 1998 in the WHI. Data analysis was conducted from February 2017 to December 2019.

Main Outcomes and Measures: Death and LTL, measured by Southern blots of the terminal restriction fragments, were the main outcomes. Cause of death was adjudicated by end point committees.

Results: The analyzed sample included 3259 participants (2342 [71.9%] women), with a median (range) age of 69.0 (50.0-98.0) years at blood collection. The median (range) follow-up until death was 10.9 (0.2-23.0) years in CHS, 19.7 (3.4-23.0) years in FHS, and 16.6 (0.5-20.0) years in WHI. During follow-up, there were 1525 deaths (482 [31.6%] of cardiovascular disease; 373 [24.5%] of cancer, and 670 [43.9%] of other or unknown causes). Short LTL, expressed in residual LTL, was associated with increased mortality risk. Overall, the hazard ratio for all-cause mortality for a 1-kilobase decrease in LTL was 1.34 (95% CI, 1.21-1.47). This association was stronger for noncancer causes of death (cardiovascular death: hazard ratio, 1.28; 95% CI, 1.08-1.52; cancer: hazard ratio, 1.13; 95% CI, 0.93-1.36; and other causes: hazard ratio, 1.53; 95% CI, 1.32-1.77).

Conclusions and Relevance: The results of this study indicate that LTL is associated with a natural life span limit in contemporary humans.

1 aArbeev, Konstantin, G1 aVerhulst, Simon1 aSteenstrup, Troels1 aKark, Jeremy, D1 aBagley, Olivia1 aKooperberg, Charles1 aReiner, Alexander, P1 aHwang, Shih-Jen1 aLevy, Daniel1 aFitzpatrick, Annette, L1 aChristensen, Kaare1 aYashin, Anatoliy, I1 aAviv, Abraham uhttps://chs-nhlbi.org/node/8282