02928nas a2200385 4500008004100000022001400041245015000055210006900205260000900274300001000283490000700293520182500300653000902125653002202134653001002156653001302166653002302179653002402202653001102226653001802237653001102255653004002266653003102306653001502337653003102352100001402383700001402397700001302411700002002424700001702444700001402461700001402475700001802489856003502507 2005 eng d a0251-535000aMorphometric analysis of gray matter volume in demented older adults: exploratory analysis of the cardiovascular health study brain MRI database.0 aMorphometric analysis of gray matter volume in demented older ad c2005 a221-90 v243 a
We tested the feasibility of a fully automated brain MRI voxel count technique--automated labeling pathway (ALP)--in a sample of 15 demented and 13 cognitively normal women (age 75-85 years) participating to the Cardiovascular Health Study (CHS). We hypothesized that ALP would replicate well-established findings of the anatomical correlates of dementia. In particular, we hypothesized that ALP volumetric measures would: (1) significantly differ between cognitively normal and demented women in those brain areas that are established markers for diagnosis of dementia (temporal and medial temporal lobes, hippocampus, amygdala and parahippocampus) but not in other brain areas (e.g., occipital lobe, visual cortex, motor cortex) and (2) correlate with visual ratings of brain disease which have been previously collected as part of the CHS. ALP required minimal operator intervention (input of brain images and verification of misalignments) and employed computer time of about 1 h per brain. ALP detected significant focal volumetric differences in the limbic system (p values between groups for hippocampus and parahippocampus: 0.002 and 0.005, respectively), temporal lobe (p < 0.0001) and caudate (p = 0.009), but not in other brain areas (e.g. occipital lobe, visual or motor cortex). Furthermore, ALP measures of medial temporal lobe atrophy strongly correlated with CHS visual ratings of ventricular enlargement (r(2) = 0.6, p = 0.002 for medial temporal lobe). In conclusion, ALP-detected focal brain atrophy was strongly associated with dementia. Because of its fully automated design, ALP technique is an ideal candidate to assess whether volumetric measures of specific areas can discriminate dementia better than currently available measures of global brain atrophy in large epidemiological studies.
10aAged10aAged, 80 and over10aBrain10aDementia10aEducational Status10aFeasibility Studies10aFemale10aHealth Status10aHumans10aImage Processing, Computer-Assisted10aMagnetic Resonance Imaging10aOrgan Size10aReproducibility of Results1 aRosano, C1 aBecker, J1 aLopez, O1 aLopez-Garcia, P1 aCarter, C, S1 aNewman, A1 aKuller, L1 aAizenstein, H uhttps://chs-nhlbi.org/node/832