02307nas a2200241 4500008004100000022001400041245011000055210006900165260001600234520155400250100002401804700001901828700001801847700002001865700002001885700002401905700002101929700001601950700002201966700001801988700002302006856003602029 2020 eng d a1758-535X00aLevel and change in N-terminal pro B-type Natriuretic Peptide and kidney function and survival to age 90.0 aLevel and change in Nterminal pro Btype Natriuretic Peptide and  c2020 May 173 a

BACKGROUND: Many traditional cardiovascular risk factors do not predict survival to very old age. Studies have shown associations of estimated glomerular filtration rate (eGFR) and N-terminal pro-B-type natriuretic peptide (NT-pro-BNP) with cardiovascular disease and mortality in older populations. This study aimed to evaluate the associations of the level and change in eGFR and NT-pro-BNP with longevity to age 90 years.

METHODS: The population included participants (n=3,645) in the Cardiovascular Health Study, aged between 67-75 at baseline. The main exposures were eGFR, calculated with the Berlin Initiative Study equation (BIS2), and NT-pro-BNP, and the main outcome was survival to age 90. Mixed models were used to estimate level and change of the main exposures.

RESULTS: There was an association between baseline level and change of both eGFR and NT-pro-BNP and survival to 90, and this association persisted after adjustment for covariates. Each 10 ml/min per 1.73 m2 higher eGFR level was associated with an adjusted odds ratio (OR) of 1.23 (95% CI: 1.13, 1.34) of survival to 90, and a 0.5 ml/min/ 1.73 m2 slower decline in eGFR was associated with an OR of 1.51 (95% CI: 1.31, 1.74). A 2-fold higher level of NT-pro-BNP level had an adjusted OR of 0.67 (95% CI: 0.61, 0.73), and a 1.05-fold increase per year in NT-pro-BNP had an OR of 0.53 (95% CI: 0.43, 0.65) for survival to age 90.

CONCLUSION: eGFR and NT-pro-BNP appear to be important risk factors for longevity to age 90.

1 aHäberle, Astrid, D1 aBiggs, Mary, L1 aCushman, Mary1 aPsaty, Bruce, M1 aNewman, Anne, B1 aShlipak, Michael, G1 aGottdiener, John1 aWu, Chenkai1 aGardin, Julius, M1 aBansal, Nisha1 aOdden, Michelle, C uhttps://chs-nhlbi.org/node/8395