02500nas a2200253   4500008004100000022001400041245010100055210006900156260001600225300001200241490000600253520174600259100001902005700001702024700002102041700002302062700001902085700002502104700001702129700002002146700002202166700002202188856003602210       2020                        eng d  a2047-998000aCarotid Intima-Media Thickness and the Risk of Sudden Cardiac Death: The ARIC Study and the CHS.0 aCarotid IntimaMedia Thickness and the Risk of Sudden Cardiac Dea  c2020 Oct 20  ae0169810 v93 a<p>Background Sudden cardiac death (SCD) is associated with severe coronary heart disease in the great majority of cases. Whether carotid intima-media thickness (C-IMT), a known surrogate marker of subclinical atherosclerosis, is associated with risk of SCD in a general population remains unknown. The objective of this study was to investigate the association between C-IMT and risk of SCD. Methods and Results We examined a total of 20 862 participants: 15 307 participants of the ARIC (Atherosclerosis Risk in Communities) study and 5555 participants of the CHS (Cardiovascular Health Study). C-IMT and common carotid artery intima-media thickness was measured at baseline by ultrasound. Presence of plaque was judged by trained readers. Over a median of 23.5 years of follow-up, 569 participants had SCD (1.81 cases per 1000 person-years) in the ARIC study. Mean C-IMT and common carotid artery intima-media thickness were associated with risk of SCD after adjustment for traditional risk factors and time-varying adjustors: hazard ratios (HRs) with 95% CIs for fourth versus first quartile were 1.64 (1.15-2.63) and 1.49 (1.05-2.11), respectively. In CHS, 302 participants developed SCD (4.64 cases per 1000 person-years) over 13.1 years. Maximum C-IMT was associated with risk of SCD after adjustment: HR (95% CI) for fourth versus first quartile was 1.75 (1.22-2.51). Presence of plaque was associated with 35% increased risk of SCD: HR (95% CI) of 1.37 (1.13-1.67) in the ARIC study and 1.32 (1.04-1.68) in CHS. Conclusions C-IMT was associated with risk of SCD in 2 biracial community-based cohorts. C-IMT may be used as a marker of SCD risk and potentially to initiate early therapeutic interventions to mitigate the risk.</p>1 aSuzuki, Takeki1 aWang, Wanmei1 aWilsdon, Anthony1 aButler, Kenneth, R1 aAdabag, Selcuk1 aGriswold, Michael, E1 aNambi, Vijay1 aRosamond, Wayne1 aSotoodehnia, Nona1 aMosley, Thomas, H  uhttps://chs-nhlbi.org/node/8489