02509nas a2200313   4500008004100000245018300041210006900224260000700293300001000300490000600310520156400316100001401880700001401894700001301908700001801921700001901939700002001958700001201978700002001990700001702010700002102027700001502048700001902063700001802082700001902100700002102119700001902140856003602159       2019                        eng d00a{Variants Associated with the Ankle Brachial Index Differ by Hispanic/Latino Ethnic Group: a genome-wide association study in the Hispanic Community Health Study/Study of Latinos0 aVariants Associated with the Ankle Brachial Index Differ by Hisp  c08  a114100 v93 aLower extremity peripheral artery disease (PAD) burden differs by race/ethnicity. Although familial aggregation and heritability studies suggest a genetic basis, little is known about the genetic susceptibility to PAD, especially in non-European descent populations. Genome-wide association studies (GWAS) of the ankle brachial index (ABI) and PAD (defined as an ABI < 0.90) have not been conducted in Hispanics/Latinos. We performed a GWAS of PAD and the ABI in 7,589 participants aged >45 years from the Hispanic Community Health Study/Study of Latinos (HCHS/SOL). We also performed GWAS for ABI stratified by Hispanic/Latino ethnic subgroups: Central American, Mexican, and South American (Mainland group), and Cuban, Dominican, and Puerto Rican (Caribbean group). We detected two genome-wide significant associations for the ABI in COMMD10 in Puerto Ricans, and at SYBU in the Caribbean group. The lead SNP rs4466200 in the COMMD10 gene had a replication p = 0.02 for the ABI in Multi-Ethnic Study of Atherosclerosis (MESA) African Americans, but it did not replicate in African Americans from the Cardiovascular Health Study (CHS). In a regional look-up, a nearby SNP rs12520838 had Bonferroni adjusted p = 0.05 (unadjusted p = 7.5 Ã— 10-5) for PAD in MESA Hispanics. Among three suggestive associations (p < 10-7) in subgroup-specific analyses, DMD on chromosome X, identified in Central Americans, replicated in MESA Hispanics (p = 2.2 Ã— 10-4). None of the previously reported ABI and PAD associations in whites generalized to Hispanics/Latinos.1 aSofer, T.1 aEmery, L.1 aJain, D.1 aEllis, A., M.1 aLaurie, C., C.1 aAllison, M., A.1 aLee, J.1 aKurniansyah, N.1 aKerr, K., F.1 aGonz?lez, H., M.1 aTarraf, W.1 aCriqui, M., H.1 aLange, L., A.1 aPalmas, W., R.1 aFranceschini, N.1 aWassel, C., L.  uhttps://chs-nhlbi.org/node/8529