02874nas a2200409 4500008004100000022001400041245014200055210006900197260001300266300001400279490000700293520165500300653000901955653002201964653004501986653001102031653001802042653001802060653001102078653001702089653000902106653002602115653003602141653002402177653002402201653001802225653001602243100002602259700002302285700002302308700001902331700001902350700002102369700001902390700002002409856003502429 2005 eng d a0002-861400aWeight loss, muscle strength, and angiotensin-converting enzyme inhibitors in older adults with congestive heart failure or hypertension.0 aWeight loss muscle strength and angiotensinconverting enzyme inh c2005 Nov a1996-20000 v533 a
OBJECTIVES: To determine whether angiotensin-converting enzyme (ACE) inhibitor use may be associated with weight maintenance and sustained muscle strength (measured by grip strength) in older adults.
DESIGN: Data from the Cardiovascular Health Study (CHS), a community-based prospective cohort study of 5,888 older adults, were used.
SETTING: Subjects were recruited from four U.S. sites beginning in 1989; this analysis included data through 2001.
PARTICIPANTS: CHS participants with congestive heart failure (CHF) or treated hypertension.
MEASUREMENTS: The exposure, current ACE inhibitor use, was ascertained by medication inventory at annual clinic visits; the outcomes were weight change and grip-strength change during the following year. Multivariate linear regression was used, accounting for correlations between observations on the same participant over time.
RESULTS: The average annual weight change was -0.38 kg in 2,834 participants (14,443 person-years) with treated hypertension and -0.62 kg in 342 participants (980 person-years) with CHF. ACE inhibitor use was associated with less annual weight loss after adjustment for potential confounders: a difference of 0.17 kg (95% confidence interval (CI)=0.05-0.29) in those with treated hypertension and 0.29 kg (95% CI=-0.25-0.83) in those with CHF. There was no evidence of association between ACE inhibitor use and grip-strength change.
CONCLUSION: ACE inhibitor use may be associated with weight maintenance, but not maintenance of muscle strength, in older adults with treated hypertension.
10aAged10aAged, 80 and over10aAngiotensin-Converting Enzyme Inhibitors10aFemale10aHand Strength10aHeart Failure10aHumans10aHypertension10aMale10aMultivariate Analysis10aOutcome Assessment, Health Care10aProspective Studies10aStatistics as Topic10aUnited States10aWeight Loss1 aSchellenbaum, Gina, D1 aSmith, Nicholas, L1 aHeckbert, Susan, R1 aLumley, Thomas1 aRea, Thomas, D1 aFurberg, Curt, D1 aLyles, Mary, F1 aPsaty, Bruce, M uhttps://chs-nhlbi.org/node/868