01807nas a2200193 4500008004100000022001400041245009000055210006900145260001600214520118500230100002201415700002401437700002401461700002501485700001801510700002101528700002801549856003601577 2021 eng d a1552-527900aOphthalmic conditions associated with dementia risk: The Cardiovascular Health Study.0 aOphthalmic conditions associated with dementia risk The Cardiova c2021 Mar 313 a

INTRODUCTION: Ophthalmic conditions and dementia appear to overlap and may share common pathways, but research has not differentiated dementia subtypes.

METHODS: Diagnoses of cataracts, age-related macular degeneration (AMD), diabetic retinopathy (DR), and glaucoma were based on medical histories and International Classification of Diseases, Ninth Revision (ICD-9) codes for 3375 participants from the Cardiovascular Health Study. Dementia, including Alzheimer's disease (AD) and vascular dementia (VaD), was classified using standardized research criteria.

RESULTS: Cataracts were associated with AD (hazard ratio [HR] = 1.34; 95% confidence interval [CI] = 1.01-1.80) and VaD/mixed dementia (HR = 1.41; 95% CI = 1.02-1.95). AMD was associated with AD only (HR = 1.87; 95% CI = 1.13-3.09), whereas DR was associated with VaD/mixed dementia only (HR = 2.63; 95% CI = 1.10-6.27).

DISCUSSION: Differential associations between specific ophthalmic conditions and dementia subtypes may elucidate pathophysiologic pathways. Lack of association between glaucoma and dementia was most surprising from these analyses.

1 aHwang, Phillip, H1 aLongstreth, Will, T1 aThielke, Stephen, M1 aFrancis, Courtney, E1 aCarone, Marco1 aKuller, Lewis, H1 aFitzpatrick, Annette, L uhttps://chs-nhlbi.org/node/8708