02615nas a2200445 4500008004100000022001400041245007500055210006900130260001300199300001100212490000700223520139000230653002201620653000901642653001301651653002801664653001901692653002801711653004001739653001101779653001801790653001801808653001101826653000901837653001601846653001901862653001501881653001801896653001601914100001901930700002501949700001701974700001601991700002002007700002102027700001902048700002002067710004702087856003502134 2006 eng d a1047-279700aThe association of race with frailty: the cardiovascular health study.0 aassociation of race with frailty the cardiovascular health study c2006 Jul a545-530 v163 a
PURPOSE: Frailty, which has been conceptualized as a state of decreased physiologic reserve contributing to functional decline, has a prevalence among older African Americans that is twice that in older whites. This study assesses the independent contribution of race to frailty.
METHODS: We evaluated 786 African-American and 4491 white participants of the Cardiovascular Health Study (CHS). Frailty is defined as meeting three or more of five criteria derived from CHS measures: lowest quintile for grip strength, self-reported exhaustion, unintentional weight loss of 10 lbs or greater in 1 year, slowest quintile for gait speed, and lowest quintile for physical activity. Controlling for age, sex, comorbidity, socioeconomic factors, and race, multinomial logistic regression estimated the odds ratio (OR) of prefrail (one or two criteria) to not frail and frail to not frail.
RESULTS: Among African Americans, 8.7% of men and 15.0% of women were frail compared with 4.6% and 6.8% of white men and women, respectively. In adjusted models, nonobese African Americans had a fourfold greater odds of frailty compared with whites. The increased OR of frailty associated with African-American race was less pronounced among those who were obese or disabled.
CONCLUSION: African-American race is associated independently with frailty.
10aAfrican Americans10aAged10aAsthenia10aCardiovascular Diseases10aCohort Studies10aCross-Sectional Studies10aEuropean Continental Ancestry Group10aFemale10aFrail Elderly10aHealth Status10aHumans10aMale10aMiddle Aged10aMotor Activity10aOdds Ratio10aUnited States10aWeight Loss1 aHirsch, Calvin1 aAnderson, Melissa, L1 aNewman, Anne1 aKop, Willem1 aJackson, Sharon1 aGottdiener, John1 aTracy, Russell1 aFried, Linda, P1 aCardiovascular Health Study Research Group uhttps://chs-nhlbi.org/node/877