03731nas a2200973 4500008004100000022001400041245010000055210006900155260001500224300000900239490000700248520100600255653000901261653002201270653001901292653002501311653001101336653002201347653001101369653000901380653001601389653002501405653002401430653002301454653001701477100002301494700002201517700002101539700001601560700003001576700002001606700001801626700002201644700003001666700001701696700002301713700002301736700002201759700002001781700002201801700002101823700002301844700001601867700002301883700002501906700002101931700002401952700002101976700002601997700002102023700002402044700002202068700001902090700002102109700001802130700001902148700001502167700002102182700001902203700001802222700001802240700001702258700002402275700001602299700002002315700001702335700002602352700002402378700002202402700002102424700001602445700002002461700002102481700002502502700002002527700001802547700001402565700001202579700002402591700002402615700002502639710005702664856003602721 2021 eng d a2041-172300aBlood n-3 fatty acid levels and total and cause-specific mortality from 17 prospective studies.0 aBlood n3 fatty acid levels and total and causespecific mortality c2021 04 22 a23290 v123 a
The health effects of omega-3 fatty acids have been controversial. Here we report the results of a de novo pooled analysis conducted with data from 17 prospective cohort studies examining the associations between blood omega-3 fatty acid levels and risk for all-cause mortality. Over a median of 16 years of follow-up, 15,720 deaths occurred among 42,466 individuals. We found that, after multivariable adjustment for relevant risk factors, risk for death from all causes was significantly lower (by 15-18%, at least p < 0.003) in the highest vs the lowest quintile for circulating long chain (20-22 carbon) omega-3 fatty acids (eicosapentaenoic, docosapentaenoic, and docosahexaenoic acids). Similar relationships were seen for death from cardiovascular disease, cancer and other causes. No associations were seen with the 18-carbon omega-3, alpha-linolenic acid. These findings suggest that higher circulating levels of marine n-3 PUFA are associated with a lower risk of premature death.
10aAged10aAged, 80 and over10aCause of Death10aFatty Acids, Omega-310aFemale10aFollow-Up Studies10aHumans10aMale10aMiddle Aged10aMortality, Premature10aProspective Studies10aProtective Factors10aRisk Factors1 aHarris, William, S1 aTintle, Nathan, L1 aImamura, Fumiaki1 aQian, Frank1 aKorat, Andres, V Ardisson1 aMarklund, Matti1 aDjoussé, Luc1 aBassett, Julie, K1 aCarmichael, Pierre-Hugues1 aChen, Yun-Yu1 aHirakawa, Yoichiro1 aKüpers, Leanne, K1 aLaguzzi, Federica1 aLankinen, Maria1 aMurphy, Rachel, A1 aSamieri, Cecilia1 aSenn, Mackenzie, K1 aShi, Peilin1 aVirtanen, Jyrki, K1 aBrouwer, Ingeborg, A1 aChien, Kuo-Liong1 aEiriksdottir, Gudny1 aForouhi, Nita, G1 aGeleijnse, Johanna, M1 aGiles, Graham, G1 aGudnason, Vilmundur1 aHelmer, Catherine1 aHodge, Allison1 aJackson, Rebecca1 aKhaw, Kay-Tee1 aLaakso, Markku1 aLai, Heidi1 aLaurin, Danielle1 aLeander, Karin1 aLindsay, Joan1 aMicha, Renata1 aMursu, Jaako1 aNinomiya, Toshiharu1 aPost, Wendy1 aPsaty, Bruce, M1 aRiserus, Ulf1 aRobinson, Jennifer, G1 aShadyab, Aladdin, H1 aSnetselaar, Linda1 aSala-Vila, Aleix1 aSun, Yangbo1 aSteffen, Lyn, M1 aTsai, Michael, Y1 aWareham, Nicholas, J1 aWood, Alexis, C1 aH Y Wu, Jason1 aHu, Frank1 aSun, Qi1 aSiscovick, David, S1 aLemaitre, Rozenn, N1 aMozaffarian, Dariush1 aFatty Acids and Outcomes Research Consortium (FORCE) uhttps://chs-nhlbi.org/node/8777