02456nas a2200229 4500008004100000022001400041245010000055210006900155260001600224520173300240100002601973700002001999700001802019700002402037700002102061700002002082700001902102700002302121700002602144700002002170856003602190 2021 eng d a1526-632X00aSilent Myocardial Infarction and Subsequent Ischemic Stroke in the Cardiovascular Health Study.0 aSilent Myocardial Infarction and Subsequent Ischemic Stroke in t c2021 May 243 a

OBJECTIVE: To test the hypothesis that silent MI is a risk factor for ischemic stroke, we evaluated the association between silent MI and subsequent ischemic stroke in the Cardiovascular Health Study.

METHODS: The Cardiovascular Health Study prospectively enrolled community-dwelling individuals ≥65 years of age. We included participants without prevalent stroke or baseline evidence of MI. Our exposures were silent and clinically apparent, overt MI. Silent MI was defined as new evidence of Q-wave MI, without clinical symptoms of MI, on ECGs performed during annual study visits from 1989-1999. The primary outcome was incident ischemic stroke. Secondary outcomes were ischemic stroke subtypes: non-lacunar, lacunar, and other/unknown. Cox proportional hazards analysis was used to model the association between time-varying MI status (silent, overt, or no MI) and stroke after adjustment for baseline demographics and vascular risk factors.

RESULTS: Among 4,224 participants, 362 (8.6%) had an incident silent MI, 421 (10.0%) an incident overt MI, and 377 (8.9%) an incident ischemic stroke during a median follow-up of 9.8 years. After adjustment for demographics and comorbidities, silent MI was independently associated with subsequent ischemic stroke (HR, 1.51; 95% CI, 1.03-2.21). Overt MI was associated with ischemic stroke both in the short term (HR, 80; 95% CI, 53-119) and long term (HR, 1.60; 95% CI, 1.04-2.44). In secondary analyses, the association between silent MI and stroke was limited to non-lacunar ischemic stroke (HR 2.40; 95% CI, 1.36-4.22).

CONCLUSION: In a community-based sample, we found an association between silent MI and ischemic stroke.

1 aMerkler, Alexander, E1 aBartz, Traci, M1 aKamel, Hooman1 aSoliman, Elsayed, Z1 aHoward, Virginia1 aPsaty, Bruce, M1 aOkin, Peter, M1 aSafford, Monika, M1 aElkind, Mitchell, S V1 aLongstreth, W T uhttps://chs-nhlbi.org/node/8785