01828nas a2200205 4500008004100000022001400041245009700055210006900152260001600221520117400237100002901411700002201440700001601462700002301478700002801501700001701529700002001546700002001566856003601586 2021 eng d a1552-527900aBody mass index in early adulthood and dementia in late life: Findings from a pooled cohort.0 aBody mass index in early adulthood and dementia in late life Fin c2021 May 133 a

INTRODUCTION: To examine the independent association of body mass index (BMI) in early adulthood with dementia incidence among men and women.

METHODS: We studied 5104 older adults from the Cardiovascular Health Study (CHS) and the Health, Aging, and Body Composition (Health ABC) study. We imputed early adulthood and midlife BMI using a pooled parent cohort with complete adult lifespan coverage and previously established methods. Dementia was ascertained using criteria such as neuropsychological test battery, medical records, and dementia-related drug use. Pooled logistic regression (PLR) models were used.

RESULTS: Compared to women with normal BMI in early adulthood, the odds of dementia were higher among both overweight (odds ratio [OR] = 1.8; 95% confidence interval [CI] = 1.31 to 2.54) and obese (OR = 2.45; 95% CI = 1.47 to 4.06) women, independent of mid- and late-life BMI. Similar relationship was observed in men.

CONCLUSIONS: With the growing obesity epidemic among US adults, efforts aimed at reducing dementia may need to begin obesity prevention and treatment early in the life course.

1 aHazzouri, Adina, Zeki Al1 aVittinghoff, Eric1 aHoang, Tina1 aGolden, Sherita, H1 aFitzpatrick, Annette, L1 aZhang, Adina1 aGrasset, Leslie1 aYaffe, Kristine uhttps://chs-nhlbi.org/node/8793