02302nas a2200229 4500008004100000022001400041245010300055210006900158260001600227520158200243100002401825700002101849700002101870700002001891700002001911700001801931700002101949700002201970700002001992700002402012856003602036 2022 eng d a1555-716200aThe Association of Lipids and Lipoproteins with Hip Fracture Risk the Cardiovascular Health Study.0 aAssociation of Lipids and Lipoproteins with Hip Fracture Risk th c2022 Jun 063 a

BACKGROUND: It is uncertain if lipids or lipoproteins are associated with osteoporotic fractures. In this study, incident hip fracture risk according to conventional lipid levels and lipoprotein levels and sizes was examined.

METHODS: We followed 5832 participants aged ≥65 years from the Cardiovascular Health Study for hip fracture for a mean of 13.5 (SD 5.7) years. Standard enzymatic methods were used to determine lipid levels (HDL-c, LDL-c, triglycerides). Nuclear magnetic resonance spectroscopy was used to measure lipoprotein fractions (VLDL-P, LDL-P, HDL-P) in a subset of 1849 participants.

RESULTS: We documented 755 incident hip fractures among women (1.19 fractures per 100 participant years [95% CI, 1.04, 1.35]) and 197 among men (0.67 fractures per 100 participant years [95% CI, 0.41, 1.10]) over an average follow-up. HDL-c and LDL-c levels had statistically significant non-linear U-shaped relationships with hip fracture risk (HDL-c, p=0.009; LDL-c, p=0.02). Triglyceride levels were not significantly associated with hip fracture risk. In fully adjusted conjoint models, higher VLDL-P concentration [HR per 1-standard (SD) increment 1.47 (1.13, 1.91)] and size [HR per 1-SD increment 1.24 [1.05, 1.46]) and higher HDL-P size (HR per 1-SD increment 1.81 [1.25, 2.62]) were all associated with higher hip fracture risk.

CONCLUSIONS: Lipids and lipoproteins are associated with hip fracture risk in older adults. The associations are complex. Mechanistic studies are needed to understand these findings.

1 aBarzilay, Joshua, I1 aBůzková, Petra1 aKuller, Lewis, H1 aCauley, Jane, A1 aFink, Howard, A1 aSheets, Kerry1 aRobbins, John, A1 aCarbone, Laura, D1 aElam, Rachel, E1 aMukamal, Kenneth, J uhttps://chs-nhlbi.org/node/9087