02997nas a2200349 4500008004100000022001400041245009800055210006900153260001600222300001100238490000700249520203700256653000902293653001202302653002602314653002802340653000902368653002402377653002502401653001102426653001102437653001002448653001502458653001102473653000902484653002502493100002502518700002302543700002202566700002402588856003502612 2006 eng d a1558-359700aDietary fish and n-3 fatty acid intake and cardiac electrocardiographic parameters in humans.0 aDietary fish and n3 fatty acid intake and cardiac electrocardiog c2006 Aug 01 a478-840 v483 a

OBJECTIVES: We evaluated the association between dietary fish intake and several cardiac electrocardiographic parameters in humans relevant to arrhythmic risk.

BACKGROUND: Fish consumption may reduce the incidence of sudden death and atrial fibrillation, possibly related to anti-arrhythmic effects.

METHODS: In a population-based study of 5,096 men and women, we evaluated cross-sectional associations between usual dietary fish intake and electrocardiographic measures of heart rate, atrioventricular conduction (PR interval), ventricular repolarization (QT interval), and ventricular conduction (QRS interval). Multivariate models were adjusted for age, gender, race, education, smoking, body mass index, diabetes, coronary heart disease, physical activity, and intakes of beef or pork, fried fish, fruits, vegetables, alcohol, and total calories.

RESULTS: Consumption of tuna or other broiled or baked fish (comparing the highest to the lowest category of intake) was associated with lower heart rate (-3.2 beats/min, 95% confidence interval [CI] = 1.3 to 5.1; p trend <0.001), slower atrioventricular conduction (PR interval +7.2 ms, 95% CI = 1.4 to 12.9; p trend = 0.03), and substantially lower likelihood of prolonged QT (relative risk = 0.50, 95% CI = 0.27 to 0.95; p trend = 0.03). Tuna/other fish intake was not associated with ventricular conduction (p = 0.60). Findings were similar for estimated intake of marine n-3 fatty acids: a 1 g/day higher intake was associated with 2.3 beats/min lower heart rate (95% CI = 0.9 to 3.7), 7.6 ms longer PR interval (95% CI = 3.3 to 11.9), and 46% lower likelihood of prolonged QT (relative risk = 0.54, 95% CI = 0.33 to 0.88).

CONCLUSIONS: These findings in this large, population-based study suggest that dietary fish intake is associated with cardiac electrophysiology in humans, including heart rate, atrioventricular conduction, and ventricular repolarization, with potential implications for arrhythmic risk.

10aAged10aAnimals10aAtrioventricular Node10aCross-Sectional Studies10aDiet10aElectrocardiography10aFatty Acids, Omega-310aFemale10aFishes10aHeart10aHeart Rate10aHumans10aMale10aVentricular Function1 aMozaffarian, Dariush1 aPrineas, Ronald, J1 aStein, Phyllis, K1 aSiscovick, David, S uhttps://chs-nhlbi.org/node/910