02586nas a2200421 4500008004100000022001400041245011700055210006900172260001300241300001000254490000700264520139000271653000901661653002201670653001001692653002101702653002001723653002301743653002801766653002501794653001101819653001101830653001701841653002101858653000901879653002601888653001201914653001501926653003201941653001701973653003001990100002502020700002102045700002102066700002202087700002002109856003502129 2007 eng d a1524-463600aSerum amyloid P and cardiovascular disease in older men and women: results from the Cardiovascular Health Study.0 aSerum amyloid P and cardiovascular disease in older men and wome c2007 Feb a352-80 v273 a
OBJECTIVE: Serum amyloid P (SAP), a pentraxin like C-reactive protein (CRP), functions in innate immunity. However, associations of SAP with cardiovascular disease (CVD) are unknown.
METHODS AND RESULTS: We examined these associations in the Cardiovascular Health Study using a case-cohort design. Nonexclusive case groups were incident angina (n=523), myocardial infarction (MI; n=308), stroke (n=323), and CVD death (n=288). 786 participants had no events. SAP was correlated with CRP, CVD risk factors (obesity, blood pressure, lipids), common and internal carotid wall thickness, and ankle-brachial index (all P<0.02). In Cox regression models adjusted for age, sex, and ethnicity, a standard deviation increase in SAP (9.8 mg/L) was associated with angina (hazard ratio; 95% confidence interval 1.3; 1.2 to 1.5) and MI (1.3; 1.1 to 1.5), but not stroke (1.1; 0.9 to 1.3) or CVD death (1.1; 0.9 to 1.3). Adding CRP to the models had no significant effect on associations. Adjusting for CVD risk factors slightly attenuated SAP associations with CVD events; however, associations with angina and MI remained significant.
CONCLUSIONS: Although both are pentraxins, SAP and CRP may represent different facets of inflammation. The association of SAP with CVD in these older adults further supports the role of innate immunity in atherosclerosis.
10aAged10aAged, 80 and over10aAging10aAngina, Unstable10aAtherosclerosis10aC-Reactive Protein10aCardiovascular Diseases10aCase-Control Studies10aFemale10aHumans10aHypertension10aImmunity, Innate10aMale10aMyocardial Infarction10aObesity10aPrevalence10aProportional Hazards Models10aRisk Factors10aSerum Amyloid P-Component1 aJenny, Nancy, Swords1 aArnold, Alice, M1 aKuller, Lewis, H1 aTracy, Russell, P1 aPsaty, Bruce, M uhttps://chs-nhlbi.org/node/930