02577nas a2200361 4500008004100000022001400041245011100055210006900166260001700235300001100252490000700263520154200270653000901812653002201821653002801843653002801871653002401899653001101923653001901934653001101953653002301964653002501987653000902012653001602021653001802037100001402055700002402069700001802093700002302111700002802134700001802162856003502180 2007 eng d a0928-658600aDepressive symptoms and age-related macular degeneration in older people: the cardiovascular health study.0 aDepressive symptoms and agerelated macular degeneration in older c2007 May-Jun a127-330 v143 a
PURPOSE: To examine the association between age-related macular degeneration (AMD) and depressive symptoms.
METHODS: Population-based, cross-sectional study. A total of 2,194 persons aged 69-97 years were included in the current analyses. During the 1997-1998 examination, retinal photography from one randomly selected eye was graded for presence of early and late AMD using a modified Wisconsin AMD by Grading System. Depressive symptoms were assessed via a modified version of the Centers for Epidemiologic Studies Depression (CES-D) scale annually from 1989 through 1997-1998. Depressive symptoms were defined as a CES-D score of >9 (top quartile of CES-D score) at the 1997-1998 examination.
RESULTS: There were 338 (15.6%) individuals with early AMD and 29 (1.3%) with late AMD. Among them, 368 (16.8%) persons had depressive symptoms at the 1997-1998 examination. Depressive symptoms were not associated with early AMD (multivariable adjusted odds ratio [OR]: 0.97; 95% confidence intervals [CI]: 0.69-1.36) or late AMD (OR: 1.15; 95% CI: 0.38-3.46). Including persons using anti-depressive medications did not alter these associations (OR: 0.98; 95% CI: 0.74-1.32 for early AMD and OR: 0.97; 95% CI: 0.35-2.67 for late AMD). There was no association in multinomial logistic regression models of increasing quartiles of the CES-D scores with early or late AMD status.
CONCLUSIONS: Our study did not find an association between early AMD and depressive symptoms in older people.
10aAged10aAged, 80 and over10aCardiovascular Diseases10aCross-Sectional Studies10aDepressive Disorder10aFemale10aHealth Surveys10aHumans10aIntelligence Tests10aMacular Degeneration10aMale10aPhotography10aUnited States1 aSun, Cong1 aTikellis, Gabriella1 aKlein, Ronald1 aSteffens, David, C1 aLarsen, Emily, K Marino1 aWong, Tien, Y uhttps://chs-nhlbi.org/node/968