02535nas a2200217 4500008004100000022001400041245008000055210006900135260001600204520187300220100002202093700002202115700002102137700001302158700002402171700002202195700002202217700001902239700002302258856003602281 2018 eng d a1932-873700aAtrial fibrillation in an African-American cohort: The Jackson Heart Study.0 aAtrial fibrillation in an AfricanAmerican cohort The Jackson Hea c2018 Jul 023 a

BACKGROUND: Atrial fibrillation (AF) is an important public health problem across race/ethnic groups. Data from US cohort studies initiated in the 1980s suggest a higher prevalence of AF risk factors among African-Americans (AAs) than whites, but lower AF incidence. The Jackson Heart Study (JHS) is a community-based study of 5306 AAs recruited starting in 2000.

HYPOTHESIS: Demographic, anthropometric, cardiovascular, and/or electrocardiographic factors are associated with AF incidence in JHS.

METHODS: Using baseline participant characteristics and incident AF identified through hospital surveillance, study electrocardiogram, and Medicare claims, we estimated age- and sex-specific AF incidence rates, compared them with rates in AA participants in the Multi-Ethnic Study of Atherosclerosis (MESA) and Cardiovascular Health Study (CHS), and examined associations of cardiovascular risk factors with AF.

RESULTS: A total of 66 participants had prevalent AF at baseline. Over an average follow-up of 8.5 years, 242 cases of incident AF were identified. Age- and sex-specific AF incidence rates in JHS were similar to those among AAs in MESA and appeared slightly lower than those among AAs in CHS. In an age- and sex-adjusted model, associations with incident AF were observed for modifiable risk factors: high body weight (HR = 1.23 per 15 kg, 95%CI 1.13-1.35), systolic blood pressure (HR = 1.29 per 20 mmHg, 95%CI 1.13-1.47), and current smoking (HR = 1.80, 95%CI 1.27-2.55). Risk estimates associated with these risk factors were only slightly attenuated after multivariable adjustments.

CONCLUSIONS: These findings underscore the potential additional benefits of interventions for weight management, control of hypertension, and smoking cessation for the prevention of AF among AAs.

1 aAustin, Thomas, R1 aWiggins, Kerri, L1 aBlackshear, Chad1 aYang, Yi1 aBenjamin, Emelia, J1 aCurtis, Lesley, H1 aSotoodehnia, Nona1 aCorrea, Adolfo1 aHeckbert, Susan, R uhttps://chs-nhlbi.org/node/7779