02876nas a2200361 4500008004100000022001400041245009900055210006900154260001500223300001400238490000700252520187000259653000902129653002202138653002502160653001102185653002502196653001102221653000902232653001702241653001702258653001202275653001802287100002102305700002202326700002402348700002002372700002402392700002102416700002102437700002002458856003602478 2020 eng d a1758-535X00aMetabolites Associated with Walking Ability Among the Oldest Old from the CHS All Stars Study.0 aMetabolites Associated with Walking Ability Among the Oldest Old c2020 11 13 a2371-23780 v753 a

BACKGROUND: Low walking ability is highly prevalent with advancing age and predicts major health outcomes. Metabolomics may help to better characterize differences in walking ability among older adults, providing insight into potentially altered molecular processes underlying age-related decline in functioning. We sought to identify metabolites and metabolic pathways associated with high versus low walking ability among 120 participants ages 79-95 from the CHS All Stars study.

METHODS: Using a nested case-control design, 60 randomly selected participants with low walking ability were matched one-to-one on age, gender, race, and fasting time with 60 participants with high walking ability. High versus low walking ability was defined as being in the best versus worst tertiles for both gait speed (≥0.9 vs <0.7 m/s) and the Walking Ability Index (7-9 vs 0-1). Using liquid chromatography-mass spectrometry, 569 metabolites were identified in overnight-fasting plasma.

RESULTS: Ninety-six metabolites were associated with walking ability, where 24% were triacylglycerols. Triacylglycerols that were higher among those with high walking ability consisted mostly of polyunsaturated fatty acids, whereas triacylglycerols that were lower among those with high walking ability consisted mostly of saturated or monounsaturated fatty acids. Body composition partly explained associations between some metabolites and walking ability. Proline and arginine metabolism was a top pathway associated with walking ability.

CONCLUSION: These results may partly reflect pathways of modifiable risk factors, including excess dietary lipids and lack of physical activity, contributing to obesity and further alterations in metabolic pathways that lead to age-related decline in walking ability in this older adult cohort.

10aAged10aAged, 80 and over10aCase-Control Studies10aFemale10aGeriatric Assessment10aHumans10aMale10aMetabolomics10aRisk Factors10aWalking10aWalking Speed1 aMarron, Megan, M1 aWendell, Stacy, G1 aBoudreau, Robert, M1 aClish, Clary, B1 aSantanasto, Adam, J1 aTseng, George, C1 aZmuda, Joseph, M1 aNewman, Anne, B uhttps://chs-nhlbi.org/node/865503264nas a2200409 4500008004100000022001400041245010500055210006900160260001300229300001400242490000700256520207500263100002202338700001702360700002102377700001702398700002102415700002102436700002402457700002402481700001702505700002302522700001902545700002702564700002202591700002302613700001902636700001802655700002102673700001902694700002002713700001902733700001502752700002902767700002202796856003602818 2020 eng d a1532-541500aPutative Cut-Points in Sarcopenia Components and Incident Adverse Health Outcomes: An SDOC Analysis.0 aPutative CutPoints in Sarcopenia Components and Incident Adverse c2020 Jul a1429-14370 v683 a

OBJECTIVES: Analyses performed by the Sarcopenia Definitions and Outcomes Consortium (SDOC) identified cut-points in several metrics of grip strength for consideration in a definition of sarcopenia. We describe the associations between the SDOC-identified metrics of low grip strength (absolute or standardized to body size/composition); low dual-energy x-ray absorptiometry (DXA) lean mass as previously defined in the literature (appendicular lean mass [ALM]/ht ); and slowness (walking speed <.8 m/s) with subsequent adverse outcomes (falls, hip fractures, mobility limitation, and mortality).

DESIGN: Individual-level, sex-stratified pooled analysis. We calculated odds ratios (ORs) or hazard ratios (HRs) for incident falls, mobility limitation, hip fractures, and mortality. Follow-up time ranged from 1 year for falls to 8.8 ± 2.3 years for mortality.

SETTING: Eight prospective observational cohort studies.

PARTICIPANTS: A total of 13,421 community-dwelling men and 4,828 community-dwelling women. MEASUREMENTS Grip strength by hand dynamometry, gait speed, and lean mass by DXA.

RESULTS: Low grip strength (absolute or standardized to body size/composition) was associated with incident outcomes, usually independently of slowness, in both men and women. ORs and HRs generally ranged from 1.2 to 3.0 for those below vs above the cut-point. DXA lean mass was not consistently associated with these outcomes. When considered together, those who had both muscle weakness by absolute grip strength (<35.5 kg in men and <20 kg in women) and slowness were consistently more likely to have a fall, hip fracture, mobility limitation, or die than those without either slowness or muscle weakness.

CONCLUSION: Older men and women with both muscle weakness and slowness have a higher likelihood of adverse health outcomes. These results support the inclusion of grip strength and walking speed as components in a summary definition of sarcopenia. J Am Geriatr Soc 68:1429-1437, 2020.

1 aCawthon, Peggy, M1 aManini, Todd1 aPatel, Sheena, M1 aNewman, Anne1 aTravison, Thomas1 aKiel, Douglas, P1 aSantanasto, Adam, J1 aEnsrud, Kristine, E1 aXue, Qian-Li1 aShardell, Michelle1 aDuchowny, Kate1 aErlandson, Kristine, M1 aPencina, Karol, M1 aFielding, Roger, A1 aMagaziner, Jay1 aKwok, Timothy1 aKarlsson, Magnus1 aOhlsson, Claes1 aMellström, Dan1 aHirani, Vasant1 aRibom, Eva1 aCorrea-de-Araujo, Rosaly1 aBhasin, Shalender uhttps://chs-nhlbi.org/node/8377