03264nas a2200409 4500008004100000022001400041245010500055210006900160260001300229300001400242490000700256520207500263100002202338700001702360700002102377700001702398700002102415700002102436700002402457700002402481700001702505700002302522700001902545700002702564700002202591700002302613700001902636700001802655700002102673700001902694700002002713700001902733700001502752700002902767700002202796856003602818 2020 eng d a1532-541500aPutative Cut-Points in Sarcopenia Components and Incident Adverse Health Outcomes: An SDOC Analysis.0 aPutative CutPoints in Sarcopenia Components and Incident Adverse c2020 Jul a1429-14370 v683 a

OBJECTIVES: Analyses performed by the Sarcopenia Definitions and Outcomes Consortium (SDOC) identified cut-points in several metrics of grip strength for consideration in a definition of sarcopenia. We describe the associations between the SDOC-identified metrics of low grip strength (absolute or standardized to body size/composition); low dual-energy x-ray absorptiometry (DXA) lean mass as previously defined in the literature (appendicular lean mass [ALM]/ht ); and slowness (walking speed <.8 m/s) with subsequent adverse outcomes (falls, hip fractures, mobility limitation, and mortality).

DESIGN: Individual-level, sex-stratified pooled analysis. We calculated odds ratios (ORs) or hazard ratios (HRs) for incident falls, mobility limitation, hip fractures, and mortality. Follow-up time ranged from 1 year for falls to 8.8 ± 2.3 years for mortality.

SETTING: Eight prospective observational cohort studies.

PARTICIPANTS: A total of 13,421 community-dwelling men and 4,828 community-dwelling women. MEASUREMENTS Grip strength by hand dynamometry, gait speed, and lean mass by DXA.

RESULTS: Low grip strength (absolute or standardized to body size/composition) was associated with incident outcomes, usually independently of slowness, in both men and women. ORs and HRs generally ranged from 1.2 to 3.0 for those below vs above the cut-point. DXA lean mass was not consistently associated with these outcomes. When considered together, those who had both muscle weakness by absolute grip strength (<35.5 kg in men and <20 kg in women) and slowness were consistently more likely to have a fall, hip fracture, mobility limitation, or die than those without either slowness or muscle weakness.

CONCLUSION: Older men and women with both muscle weakness and slowness have a higher likelihood of adverse health outcomes. These results support the inclusion of grip strength and walking speed as components in a summary definition of sarcopenia. J Am Geriatr Soc 68:1429-1437, 2020.

1 aCawthon, Peggy, M1 aManini, Todd1 aPatel, Sheena, M1 aNewman, Anne1 aTravison, Thomas1 aKiel, Douglas, P1 aSantanasto, Adam, J1 aEnsrud, Kristine, E1 aXue, Qian-Li1 aShardell, Michelle1 aDuchowny, Kate1 aErlandson, Kristine, M1 aPencina, Karol, M1 aFielding, Roger, A1 aMagaziner, Jay1 aKwok, Timothy1 aKarlsson, Magnus1 aOhlsson, Claes1 aMellström, Dan1 aHirani, Vasant1 aRibom, Eva1 aCorrea-de-Araujo, Rosaly1 aBhasin, Shalender uhttps://chs-nhlbi.org/node/8377