02677nas a2200241 4500008004100000022001400041245013900055210006900194260001600263520189900279100002102178700002002199700002302219700001802242700002002260700002102280700001802301700001902319700002102338700002002359700002002379856003602399 2021 eng d a1433-928500aAssociations between neighborhood greenspace and brain imaging measures in non-demented older adults: the Cardiovascular Health Study.0 aAssociations between neighborhood greenspace and brain imaging m c2021 Jan 033 a

PURPOSE: Greater neighborhood greenspace has been associated with brain health, including better cognition and lower odds of Alzheimer's disease in older adults. We investigated associations between neighborhood greenspace and brain-based magnetic resonance imaging (MRI) measures and potential effect modification by sex or apolipoprotein E genotype (APOE), a risk factor for Alzheimer's disease.

METHODS: We obtained a sample of non-demented participants 65 years or older (n = 1125) from the longitudinal, population-based Cardiovascular Health Study (CHS). Greenspace data were derived from the National Land Cover Dataset. Adjusted multivariable linear regression estimated associations between neighborhood greenspace five years prior to the MRI and left and right hippocampal volume and 10-point grades of ventricular size and burden of white matter hyperintensity. Interaction terms tested effect modification by APOE genotype and sex. CHS data (1989-1999) were obtained/analyzed in 2020.

RESULTS: Participants were on average 79 years old [standard deviation (SD) = 4], 58% were female, and 11% were non-white race. Mean neighborhood greenspace was 38% (SD = 28%). Greater proportion of greenspace in the neighborhood five years before MRI was borderline associated with lower ventricle grade (estimate: - 0.30; 95% confidence interval: - 0.61, 0.00). We observed no associations between greenspace and the other MRI outcome measures and no evidence of effect modification by APOE genotype and sex.

CONCLUSION: This study suggests a possible association between greater greenspace and less ventricular enlargement, a measure reflecting global brain atrophy. If confirmed in other longitudinal cohort studies, interventions and policies to improve community greenspaces may help to maintain brain health in older age.

1 aBesser, Lilah, M1 aLovasi, Gina, S1 aMichael, Yvonne, L1 aGarg, Parveen1 aHirsch, Jana, A1 aSiscovick, David1 aHurvitz, Phil1 aBiggs, Mary, L1 aGalvin, James, E1 aBartz, Traci, M1 aLongstreth, W T uhttps://chs-nhlbi.org/node/8616