02649nas a2200265 4500008004100000022001400041245016700055210006900222260001600291300000700307490000700314520178800321100002502109700001902134700002402153700002202177700002002199700002002219700002302239700002202262700002002284700002002304700002302324856003602347 2021 eng d a1471-226100aNatural killer cells, gamma delta T cells and classical monocytes are associated with systolic blood pressure in the multi-ethnic study of atherosclerosis (MESA).0 aNatural killer cells gamma delta T cells and classical monocytes c2021 Jan 22 a450 v213 a

BACKGROUND: Hypertension is a major source of cardiovascular morbidity and mortality. Recent evidence from mouse models, genetic, and cross-sectional human studies suggest increased proportions of selected immune cell subsets may be associated with levels of systolic blood pressure (SBP).

METHODS: We assayed immune cells from cryopreserved samples collected at the baseline examination (2000-2002) from 1195 participants from the multi-ethnic study of atherosclerosis (MESA). We used linear mixed models, with adjustment for age, sex, race/ethnicity, smoking, exercise, body mass index, education, diabetes, and cytomegalovirus titers, to estimate the associations between 30 immune cell subsets (4 of which were a priori hypotheses) and repeated measures of SBP (baseline and up to four follow-up measures) over 10 years. The analysis provides estimates of the association with blood pressure level.

RESULTS: The mean age of the MESA participants at baseline was 64 ± 10 years and 53% were male. A one standard deviation (1-SD) increment in the proportion of γδ T cells was associated with 2.40 mmHg [95% confidence interval (CI) 1.34-3.42] higher average systolic blood pressure; and for natural killer cells, a 1-SD increment was associated with 1.88 mmHg (95% CI 0.82-2.94) higher average level of systolic blood pressure. A 1-SD increment in classical monocytes (CD14CD16) was associated with 2.01 mmHG (95% CI 0.79-3.24) lower average systolic blood pressure. There were no associations of CD4 T helper cell subsets with average systolic blood pressure.

CONCLUSION: These findings suggest that the innate immune system plays a role in levels of SBP whereas there were no associations with adaptive immune cells.

1 aDelaney, Joseph, A C1 aOlson, Nels, C1 aSitlani, Colleen, M1 aFohner, Alison, E1 aHuber, Sally, A1 aLanday, Alan, L1 aHeckbert, Susan, R1 aTracy, Russell, P1 aPsaty, Bruce, M1 aFeinstein, Matt1 aDoyle, Margaret, F uhttps://chs-nhlbi.org/node/8658