02144nas a2200253 4500008004100000022001400041245009100055210006900146260001300215300001200228490000700240520138900247653003101636653001001667653002901677653001101706653002501717653003201742100001701774700002401791700002301815700001701838856003501855 2005 eng d a0895-435600aMethods for incorporating death into health-related variables in longitudinal studies.0 aMethods for incorporating death into healthrelated variables in  c2005 Nov a1115-240 v583 a

BACKGROUND AND OBJECTIVES: Longitudinal studies of health over time may be misleading if some people die. Self-rated health (excellent to poor) and the SF-36 profile scores have been transformed to incorporate death. We applied the same approaches to incorporate death into activities of daily living difficulties (ADLs), IADLs, mini-mental state examination, depressive symptoms, blocks walked per week, bed days, the timed walk, body mass index and blood pressure.

STUDY DESIGN AND SETTING: The Cardiovascular Health Study of 5,888 older adults, was followed up to 9 years. Mean age was 73 at baseline, and 658 had an incident stroke during follow-up.

METHODS: We recoded each variable as the probability of being healthy 1 year in the future (PHF), conditional on the current value of the variable. This was done for 11 health variables, using three definitions of healthy, and two estimation models. Deaths were set to zero, and mean PHF was plotted in the 3 years before and after an incident stroke.

RESULTS: Analyses without the deaths were too optimistic. The effect of stroke was greatest on hospitalization, self-rated health, and IADLs. Alternative transformation approaches had slightly different results.

CONCLUSION: These methods provide an additional approach for handling death in longitudinal studies.

10aActivities of Daily Living10aDeath10aHealth Status Indicators10aHumans10aLongitudinal Studies10aProportional Hazards Models1 aDiehr, Paula1 aJohnson, Laura, Lee1 aPatrick, Donald, L1 aPsaty, Bruce uhttps://chs-nhlbi.org/node/861