02854nas a2200337   4500008004100000022001400041245012900055210006900184260001600253300001200269490000700281520183900288100002402127700001602151700001702167700002702184700001902211700002002230700001502250700002402265700002202289700002202311700002602333700001702359700002002376700001902396700001802415700002102433700002602454856003602480       2021                        eng d  a2047-998000aEstimating Systolic Blood Pressure Intervention Trial Participant Posttrial Survival Using Pooled Epidemiologic Cohort Data.0 aEstimating Systolic Blood Pressure Intervention Trial Participan  c2021 May 18  ae0203610 v103 a<p>Background Intensive systolic blood pressure treatment (<120 mm Hg) in SPRINT (Systolic Blood Pressure Intervention Trial) improved survival compared with standard treatment (<140 mm Hg) over a median follow-up of 3.3 years. We projected life expectancy after observed follow-up in SPRINT using SPRINT-eligible participants in the NHLBI-PCS (National Heart, Lung, and Blood Institute Pooled Cohorts Study). Methods and Results We used propensity scores to weight SPRINT-eligible NHLBI-PCS participants to resemble SPRINT participants. In SPRINT participants, we estimated in-trial survival (<4 years) using a time-based flexible parametric survival model. In SPRINT-eligible NHLBI-PCS participants, we estimated posttrial survival (≥4 years) using an age-based flexible parametric survival model and applied the formula to SPRINT participants to predict posttrial survival. We projected overall life expectancy for each SPRINT participant and compared it to parametric regression (eg, Gompertz) projections based on SPRINT data alone. We included 8584 SPRINT and 10 593 SPRINT-eligible NHLBI-PCS participants. After propensity weighting, mean (SD) age was 67.9 (9.4) and 68.2 (8.8) years, and 35.5% and 37.6% were women in SPRINT and NHLBI-PCS, respectively. Using the NHLBI-PCS-based method, projected mean life expectancy from randomization was 21.0 (7.4) years with intensive and 19.1 (7.2) years with standard treatment. Using the Gompertz regression, life expectancy was 11.2 (2.3) years with intensive and 10.5 (2.2) years with standard treatment. Conclusions Combining SPRINT and NHLBI-PCS observed data likely offers a more realistic estimate of life expectancy than parametrically extrapolating SPRINT data alone. These results offer insight into the potential long-term effectiveness of intensive SBP goals.</p>1 aBellows, Brandon, K1 aZhang, Yiyi1 aZhang, Zugui1 aLloyd-Jones, Donald, M1 aBress, Adam, P1 aKing, Jordan, B1 aKolm, Paul1 aCushman, William, C1 aJohnson, Karen, C1 aTamariz, Leonardo1 aOelsner, Elizabeth, C1 aShea, Steven1 aNewman, Anne, B1 aIves, Diane, G1 aCouper, David1 aMoran, Andrew, E1 aWeintraub, William, S  uhttps://chs-nhlbi.org/node/8770