02453nas a2200253 4500008004100000022001400041245012100055210006900176260001300245300001100258490000700269520168400276100001901960700002501979700001902004700001902023700001802042700002302060700001702083700002202100700001902122700002202141856003602163 2022 eng d a1877-783X00aSleep problems and risk of cancer incidence and mortality in an older cohort: The Cardiovascular Health Study (CHS).0 aSleep problems and risk of cancer incidence and mortality in an  c2022 Feb a1020570 v763 a

BACKGROUND: Sleep problems (SP) can indicate underlying sleep disorders, such as obstructive sleep apnea, which may adversely impact cancer risk and mortality.

METHODS: We assessed the association of baseline and longitudinal sleep apnea and insomnia symptoms with incident cancer (N = 3930) and cancer mortality (N = 4580) in the Cardiovascular Health Study. We used Cox proportional hazards regression to calculate adjusted hazard ratios (HR) and 95% confidence intervals (CI) to evaluate the associations.

RESULTS: Overall, 885 incident cancers and 804 cancer deaths were identified over a median follow-up of 12 and 14 years, respectively. Compared to participants who reported no sleep apnea symptoms, the risk of incident cancer was inversely associated [(HR (95%CI)] with snoring [0.84 (0.71, 0.99)]. We noted an elevated prostate cancer incidence for apnea [2.34 (1.32, 4.15)] and snoring [1.69 (1.11, 2.57)]. We also noted an elevated HR for lymphatic or hematopoietic cancers [daytime sleepiness: 1.81 (1.06, 3.08)]. We found an inverse relationship for cancer mortality with respect to snoring [0.73 (0.62, 0.8)] and apnea [(0.69 (0.51, 0.94))]. We noted a significant inverse relationship between difficulty falling asleep and colorectal cancer death [0.32 (0.15, 0.69)] and snoring with lung cancer death [0.56 (0.35, 0.89)].

CONCLUSIONS: The relationship between SP and cancer risk and mortality was heterogeneous. Larger prospective studies addressing more cancer sites, molecular type-specific associations, and better longitudinal SP assessments are needed for improved delineation of SP-cancer risk dyad.

1 aSillah, Arthur1 aWatson, Nathaniel, F1 aPeters, Ulrike1 aBiggs, Mary, L1 aNieto, Javier1 aLi, Christopher, I1 aGozal, David1 aThornton, Timothy1 aBarrie, Sonnah1 aPhipps, Amanda, I uhttps://chs-nhlbi.org/node/9003