02569nas a2200301 4500008004100000022001400041245012700055210006900182260001700251300001100268490000700279520165000286100002101936700002001957700002901977700002002006700002002026700002302046700001802069700002002087700002102107700002302128700001902151700002102170700002002191700002002211856003602231 2023 eng d a2352-872900aNeighborhood greenspace and neighborhood income associated with white matter grade worsening: Cardiovascular Health Study.0 aNeighborhood greenspace and neighborhood income associated with  c2023 Oct-Dec ae124840 v153 a

INTRODUCTION: We examined whether a combined measure of neighborhood greenspace and neighborhood median income was associated with white matter hyperintensity (WMH) and ventricle size changes.

METHODS: The sample included 1260 cognitively normal ≥ 65-year-olds with two magnetic resonance images (MRI; ≈ 5 years apart). WMH and ventricular size were graded from 0 (least) to 9 (most) abnormal (worsening = increase of ≥1 grade from initial to follow-up MRI scans). The four-category neighborhood greenspace-income measure was based on median neighborhood greenspace and income values at initial MRI. Multivariable logistic regression tested associations between neighborhood greenspace-income and MRI measures (worsening vs. not).

RESULTS: White matter grade worsening was more likely for those in lower greenspace-lower income neighborhoods than higher greenspace-higher income neighborhoods (odds ratio = 1.73; 95% confidence interval = 1.19-2.51).

DISCUSSION: The combination of lower neighborhood income and lower greenspace may be a risk factor for worsening white matter grade on MRI. However, findings need to be replicated in more diverse cohorts.

HIGHLIGHTS: Population-based cohort of older adults (≥ 65 years) with greenspace and MRI dataCombined measure of neighborhood greenspace and neighborhood income at initial MRIMRI outcomes included white matter hyperintensities (WMH) and ventricular sizeLongitudinal change in MRI outcomes measured approximately 5 years apartWorsening WMH over time more likely for lower greenspace-lower income neighborhoods.

1 aBesser, Lilah, M1 aLovasi, Gina, S1 aZambrano, Joyce, Jimenez1 aCamacho, Simone1 aDhanekula, Devi1 aMichael, Yvonne, L1 aGarg, Parveen1 aHirsch, Jana, A1 aSiscovick, David1 aHurvitz, Philip, M1 aBiggs, Mary, L1 aGalvin, James, E1 aBartz, Traci, M1 aLongstreth, W T uhttps://chs-nhlbi.org/node/9532