02771nas a2200265 4500008004100000022001400041245013200055210006900187260001300256490000700269520193400276100001502210700002202225700002102247700002502268700002102293700002002314700002402334700002402358700002302382700002002405700001802425700002602443856003602469 2025 eng d a2312-054100aAssociations of metabolic syndrome with lung function decline and clinical respiratory outcomes: the NHLBI Pooled Cohort Study.0 aAssociations of metabolic syndrome with lung function decline an c2025 Jul0 v113 a

BACKGROUND: Whether metabolic syndrome (MetS) increases the risk of chronic lung diseases remains uncertain. We aimed to test whether MetS was associated with lung function and clinical respiratory outcomes.

METHODS: Data were harmonised from six US general population-based prospective cohorts. Participants with baseline airflow limitation (forced expiratory volume in 1 s (FEV):forced vital capacity (FVC) <0.70), restriction (FEV:FVC ≥0.7, FVC <80%), clinical chronic lower respiratory disease (CLRD) or cardiovascular disease were excluded. MetS was defined at baseline as the presence of at least three of the following: central obesity, high triglycerides, low high-density lipoprotein cholesterol, high blood pressure (BP) and high fasting glucose. Associations with lung function decline and incident clinical respiratory events were tested in linear mixed models and Cox models, respectively, adjusted for sociodemographic, anthropometric, smoking and clinical factors. The five subcomponents of MetS were evaluated separately in secondary analyses.

RESULTS: Of 15 728 participants (mean age 49.6 years, 57.6% female, 68.6% White, 27.0% Black), 4422 (28.1%) had MetS. In fully adjusted models that included body weight, MetS was associated with greater rate of FVC decline (-0.89 mL·year, 95% CI -1.73- -0.05) and incident restriction (1085 cases, hazard ratio 1.52, 95% CI 1.30-1.77), but not FEV decline, incident airflow limitation or clinical respiratory outcomes. Among the subcomponents of MetS, central obesity, high BP and high fasting glucose were associated with incident restriction, while high BP alone was associated with incident airflow limitation, CLRD-related events and respiratory-related mortality.

CONCLUSIONS: MetS was associated with accelerated FVC decline and incident restriction, but not incident obstruction, in healthy adults.

1 aChoi, Yuni1 aBalte, Pallavi, P1 aJacobs, David, R1 aLondon, Stephanie, J1 aNavas-Acien, Ana1 aNewman, Anne, B1 aO'Connor, George, T1 aSchwartz, Joseph, E1 aSmith, Benjamin, M1 aWhite, Wendy, B1 aYende, Sachin1 aOelsner, Elizabeth, C uhttps://chs-nhlbi.org/node/9980