02828nas a2200349 4500008004100000022001400041245010500055210006900160260001600229300001300245490000800258520184300266653000902109653003802118653001102156653001102167653000902178653001602187653002002203653002002223653001002243653002602253653001502279100002102294700002202315700002202337700001602359700002002375700002302395700002402418856003602442 2010 eng d a1535-497000aSleepiness, quality of life, and sleep maintenance in REM versus non-REM sleep-disordered breathing.0 aSleepiness quality of life and sleep maintenance in REM versus n c2010 May 01 a997-10020 v1813 a

RATIONALE: The impact of REM-predominant sleep-disordered breathing (SDB) on sleepiness, quality of life (QOL), and sleep maintenance is uncertain.

OBJECTIVE: To evaluate the association of SDB during REM sleep with daytime sleepiness, health-related QOL, and difficulty maintaining sleep, in comparison to their association with SDB during non-REM sleep in a community-based cohort.

METHODS: Cross-sectional analysis of 5,649 Sleep Heart Health Study participants (mean age 62.5 [SD = 10.9], 52.6% women, 22.6% ethnic minorities). SDB during REM and non-REM sleep was quantified using polysomnographically derived apnea-hypopnea index in REM (AHI(REM)) and non-REM (AHI(NREM)) sleep. Sleepiness, sleep maintenance, and QOL were respectively quantified using the Epworth Sleepiness Scale (ESS), the Sleep Heart Health Study Sleep Habit Questionnaire, and the physical and mental composites scales of the Medical Outcomes Study Short Form (SF)-36.

MEASUREMENTS AND MAIN RESULTS: AHI(REM) was not associated with the ESS scores or the physical and mental components scales scores of the SF-36 after adjusting for demographics, body mass index, and AHI(NREM) x AHI(REM) was not associated with frequent difficulty maintaining sleep or early awakening from sleep. AHI(NREM) was associated with the ESS score (beta = 0.25; 95% confidence interval [CI], 0.16 to 0.34) and the physical (beta = -0.12; 95% CI, -0.42 to -0.01) and mental (beta = -0.20; 95% CI, -0.20 to -0.01) components scores of the SF-36 adjusting for demographics, body mass index, and AHI(REM).

CONCLUSIONS: In a community-based sample of middle-aged and older adults, REM-predominant SDB is not independently associated with daytime sleepiness, impaired health-related QOL, or self-reported sleep disruption.

10aAged10aDisorders of Excessive Somnolence10aFemale10aHumans10aMale10aMiddle Aged10aPolysomnography10aQuality of Life10aSleep10aSleep Apnea Syndromes10aSleep, REM1 aChami, Hassan, A1 aBaldwin, Carol, M1 aSilverman, Angela1 aZhang, Ying1 aRapoport, David1 aPunjabi, Naresh, M1 aGottlieb, Daniel, J uhttps://chs-nhlbi.org/node/1161