02723nas a2200337 4500008004100000022001400041245006100055210006000116260001300176300001200189490000700201520180900208653000902017653001602026653002802042653002202070653001102092653001102103653001102114653001402125653002602139100002802165700002002193700002002213700002702233700002002260700002102280700002402301700002402325856003602349 2010 eng d a1935-554800aParity and the association with diabetes in older women.0 aParity and the association with diabetes in older women c2010 Aug a1778-820 v333 a

OBJECTIVE: To examine the relationship of parity with diabetes and markers of glucose homeostasis in older women.

RESEARCH DESIGN AND METHODS: We used data from the female participants in the Cardiovascular Health Study, a longitudinal cohort of adults aged >or=65 years. These data included an assessment of parity (baseline) and fasting serum levels of glucose, insulin, and medication use (baseline and follow-up). We estimated both the cross-sectional relationship of parity with baseline diabetes and the relationship of parity with incident diabetes.

RESULTS: In unadjusted analyses, women with grand multiparity (>or=5 live births) had a higher prevalence of diabetes at baseline compared with those with fewer births and with nulliparous women (25 vs. 12 vs. 15%; P < 0.001). In regression models controlling for age and race, grand multiparity was associated with increased prevalence of diabetes (prevalence ratio 1.57 [95% CI 1.20-2.06]); with addition of demographic and clinical factors to the model, the association was attenuated (1.33 [1.00-1.77]). In final models that included body anthropometrics, the association was no longer significant (1.21 [0.86-1.49]). In those without diabetes at baseline, parity was not associated with incident diabetes or with fasting glucose; however, there was a modest association of parity with fasting insulin and homeostasis assessment model of insulin resistance.

CONCLUSIONS: Grand multiparity is associated with diabetes in elderly women in cross-sectional analyses. This relationship seems to be confounded and/or mediated by variation in body weight and sociodemographic factors by parity status. In older nondiabetic women, higher parity does not pose an ongoing risk of developing diabetes.

10aAged10aBody Weight10aCross-Sectional Studies10aDiabetes Mellitus10aFemale10aHumans10aParity10aPregnancy10aSocioeconomic Factors1 aFowler-Brown, Angela, G1 ade Boer, Ian, H1 aCatov, Janet, M1 aCarnethon, Mercedes, R1 aKamineni, Aruna1 aKuller, Lewis, H1 aSiscovick, David, S1 aMukamal, Kenneth, J uhttps://chs-nhlbi.org/node/1193