05807nas a2201045 4500008004100000022001400041245007600055210006900131260001600200300001200216490000800228520280100236653001703037653000903054653002203063653002503085653001703110653003803127653003403165653001103199653001503210653003603225100002003261700002803281700002003309700002403329700002403353700001703377700001903394700002103413700002903434700002703463700001903490700003103509700002603540700002303566700002003589700002603609700002003635700003103655700002303686700001903709700002203728700001803750700002103768700002403789700002303813700002403836700002103860700002003881700001703901700002203918700002403940700002203964700002403986700001904010700002104029700002504050700002604075700002104101700002604122700002204148700002804170700002304198700002204221700001804243700001904261700002204280700002004302700001804322700002204340700001404362700002004376700002804396700002304424700001904447700001804466700002004484700002204504700002204526700002004548700002204568700002004590700002304610700002704633710002204660710002204682710002104704856003604725 2010 eng d a1538-359800aGenome-wide analysis of genetic loci associated with Alzheimer disease.0 aGenomewide analysis of genetic loci associated with Alzheimer di c2010 May 12 a1832-400 v3033 a
CONTEXT: Genome-wide association studies (GWAS) have recently identified CLU, PICALM, and CR1 as novel genes for late-onset Alzheimer disease (AD).
OBJECTIVES: To identify and strengthen additional loci associated with AD and confirm these in an independent sample and to examine the contribution of recently identified genes to AD risk prediction in a 3-stage analysis of new and previously published GWAS on more than 35,000 persons (8371 AD cases).
DESIGN, SETTING, AND PARTICIPANTS: In stage 1, we identified strong genetic associations (P < 10(-3)) in a sample of 3006 AD cases and 14,642 controls by combining new data from the population-based Cohorts for Heart and Aging Research in Genomic Epidemiology consortium (1367 AD cases [973 incident]) with previously reported results from the Translational Genomics Research Institute and the Mayo AD GWAS. We identified 2708 single-nucleotide polymorphisms (SNPs) with P < 10(-3). In stage 2, we pooled results for these SNPs with the European AD Initiative (2032 cases and 5328 controls) to identify 38 SNPs (10 loci) with P < 10(-5). In stage 3, we combined data for these 10 loci with data from the Genetic and Environmental Risk in AD consortium (3333 cases and 6995 controls) to identify 4 SNPs with P < 1.7x10(-8). These 4 SNPs were replicated in an independent Spanish sample (1140 AD cases and 1209 controls). Genome-wide association analyses were completed in 2007-2008 and the meta-analyses and replication in 2009.
MAIN OUTCOME MEASURE: Presence of Alzheimer disease.
RESULTS: Two loci were identified to have genome-wide significance for the first time: rs744373 near BIN1 (odds ratio [OR],1.13; 95% confidence interval [CI],1.06-1.21 per copy of the minor allele; P = 1.59x10(-11)) and rs597668 near EXOC3L2/BLOC1S3/MARK4 (OR, 1.18; 95% CI, 1.07-1.29; P = 6.45x10(-9)). Associations of these 2 loci plus the previously identified loci CLU and PICALM with AD were confirmed in the Spanish sample (P < .05). However, although CLU and PICALM were confirmed to be associated with AD in this independent sample, they did not improve the ability of a model that included age, sex, and APOE to predict incident AD (improvement in area under the receiver operating characteristic curve from 0.847 to 0.849 in the Rotterdam Study and 0.702 to 0.705 in the Cardiovascular Health Study).
CONCLUSIONS: Two genetic loci for AD were found for the first time to reach genome-wide statistical significance. These findings were replicated in an independent population. Two recently reported associations were also confirmed. These loci did not improve AD risk prediction. While not clinically useful, they may implicate biological pathways useful for future research.
10aAge of Onset10aAged10aAlzheimer Disease10aCase-Control Studies10aGenetic Loci10aGenetic Predisposition to Disease10aGenome-Wide Association Study10aHumans10aOdds Ratio10aPolymorphism, Single Nucleotide1 aSeshadri, Sudha1 aFitzpatrick, Annette, L1 aIkram, Arfan, M1 aDeStefano, Anita, L1 aGudnason, Vilmundur1 aBoada, Merce1 aBis, Joshua, C1 aSmith, Albert, V1 aCarassquillo, Minerva, M1 aLambert, Jean, Charles1 aHarold, Denise1 aSchrijvers, Elisabeth, M C1 aRamirez-Lorca, Reposo1 aDebette, Stephanie1 aLongstreth, W T1 aJanssens, Cecile, J W1 aPankratz, Shane1 aDartigues, Jean, François1 aHollingworth, Paul1 aAspelund, Thor1 aHernandez, Isabel1 aBeiser, Alexa1 aKuller, Lewis, H1 aKoudstaal, Peter, J1 aDickson, Dennis, W1 aTzourio, Christophe1 aAbraham, Richard1 aAntunez, Carmen1 aDu, Yangchun1 aRotter, Jerome, I1 aAulchenko, Yurii, S1 aHarris, Tamara, B1 aPetersen, Ronald, C1 aBerr, Claudine1 aOwen, Michael, J1 aLopez-Arrieta, Jesus1 aVaradarajan, Badri, N1 aBecker, James, T1 aRivadeneira, Fernando1 aNalls, Michael, A1 aGraff-Radford, Neill, R1 aCampion, Dominique1 aAuerbach, Sanford1 aRice, Kenneth1 aHofman, Albert1 aJonsson, Palmi, V1 aSchmidt, Helena1 aLathrop, Mark1 aMosley, Thomas, H1 aAu, Rhoda1 aPsaty, Bruce, M1 aUitterlinden, André, G1 aFarrer, Lindsay, A1 aLumley, Thomas1 aRuiz, Agustin1 aWilliams, Julie1 aAmouyel, Philippe1 aYounkin, Steve, G1 aWolf, Philip, A1 aLauner, Lenore, J1 aLopez, Oscar, L1 aDuijn, Cornelia, M1 aBreteler, Monique, M B1 aCHARGE Consortium1 aGERAD1 Consortium1 aEADI1 Consortium uhttps://chs-nhlbi.org/node/119908236nas a2202509 4500008004100000022001400041245008500055210006900140260000900209300001100218490000600229520112800235653002201363653002101385653002501406653003401431653002401465653001101489653003601500653003101536100002801567700002401595700001801619700002101637700001901658700001801677700001901695700001701714700002301731700002401754700002401778700002601802700003001828700001701858700001801875700001701893700001901910700002101929700002801950700002101978700003001999700002002029700002102049700002202070700002102092700002002113700002002133700002502153700002302178700002002201700002002221700001802241700002402259700002102283700002302304700001802327700003002345700002202375700002302397700002302420700001902443700002802462700002302490700002302513700001902536700002102555700001602576700002402592700002102616700001702637700001602654700001902670700002002689700002402709700002502733700002302758700001702781700002102798700001902819700002202838700002602860700002402886700002202910700002102932700002202953700002702975700001803002700002103020700001803041700001703059700003003076700002703106700002003133700002103153700002003174700001803194700001803212700001503230700002303245700002003268700002803288700002003316700001803336700001903354700002103373700001203394700001903406700001803425700002603443700001903469700001903488700001803507700003203525700001703557700001603574700003103590700001703621700001903638700001803657700002403675700001903699700002303718700002603741700002403767700002003791700002203811700002103833700002003854700001903874700002103893700002303914700002103937700002403958700002003982700002304002700001904025700002004044700001904064700002204083700002104105700002904126700002204155700001804177700002204195700001804217700002104235700002304256700001804279700002904297700001204326700002204338700001604360700001904376700002104395700002104416700002204437700002204459700002604481700002304507700002104530700002104551700001604572700002204588700002204610700002204632700002304654700001804677700002804695700002004723700002304743700002204766700002204788700001804810700001804828700002304846700002204869700002204891700002004913700002204933700001904955700002404974700002104998700002105019700003005040700001705070700002005087700002005107700002205127700001705149700003005166700002005196700002405216700001905240700002305259700002005282700002005302700002405322700001805346700003105364700002205395700003105417700002305448700002305471700002105494700002005515700002805535700002205563700002005585710004705605710003805652856003605690 2014 eng d a1932-620300aGene-wide analysis detects two new susceptibility genes for Alzheimer's disease.0 aGenewide analysis detects two new susceptibility genes for Alzhe c2014 ae946610 v93 aBACKGROUND: Alzheimer's disease is a common debilitating dementia with known heritability, for which 20 late onset susceptibility loci have been identified, but more remain to be discovered. This study sought to identify new susceptibility genes, using an alternative gene-wide analytical approach which tests for patterns of association within genes, in the powerful genome-wide association dataset of the International Genomics of Alzheimer's Project Consortium, comprising over 7 m genotypes from 25,580 Alzheimer's cases and 48,466 controls.
PRINCIPAL FINDINGS: In addition to earlier reported genes, we detected genome-wide significant loci on chromosomes 8 (TP53INP1, p = 1.4×10-6) and 14 (IGHV1-67 p = 7.9×10-8) which indexed novel susceptibility loci.
SIGNIFICANCE: The additional genes identified in this study, have an array of functions previously implicated in Alzheimer's disease, including aspects of energy metabolism, protein degradation and the immune system and add further weight to these pathways as potential therapeutic targets in Alzheimer's disease.
10aAlzheimer Disease10aCarrier Proteins10aCase-Control Studies10aGenome-Wide Association Study10aHeat-Shock Proteins10aHumans10aPolymorphism, Single Nucleotide10aReceptors, Antigen, B-Cell1 aEscott-Price, Valentina1 aBellenguez, Céline1 aSan Wang, Li-1 aChoi, Seung-Hoan1 aHarold, Denise1 aJones, Lesley1 aHolmans, Peter1 aGerrish, Amy1 aVedernikov, Alexey1 aRichards, Alexander1 aDeStefano, Anita, L1 aLambert, Jean-Charles1 aIbrahim-Verbaas, Carla, A1 aNaj, Adam, C1 aSims, Rebecca1 aJun, Gyungah1 aBis, Joshua, C1 aBeecham, Gary, W1 aGrenier-Boley, Benjamin1 aRusso, Giancarlo1 aThornton-Wells, Tricia, A1 aDenning, Nicola1 aSmith, Albert, V1 aChouraki, Vincent1 aThomas, Charlene1 aIkram, Arfan, M1 aZelenika, Diana1 aVardarajan, Badri, N1 aKamatani, Yoichiro1 aLin, Chiao-Feng1 aSchmidt, Helena1 aKunkle, Brian1 aDunstan, Melanie, L1 aVronskaya, Maria1 aJohnson, Andrew, D1 aRuiz, Agustin1 aBihoreau, Marie-Thérèse1 aReitz, Christiane1 aPasquier, Florence1 aHollingworth, Paul1 aHanon, Olivier1 aFitzpatrick, Annette, L1 aBuxbaum, Joseph, D1 aCampion, Dominique1 aCrane, Paul, K1 aBaldwin, Clinton1 aBecker, Tim1 aGudnason, Vilmundur1 aCruchaga, Carlos1 aCraig, David1 aAmin, Najaf1 aBerr, Claudine1 aLopez, Oscar, L1 aDe Jager, Philip, L1 aDeramecourt, Vincent1 aJohnston, Janet, A1 aEvans, Denis1 aLovestone, Simon1 aLetenneur, Luc1 aHernandez, Isabel1 aRubinsztein, David, C1 aEiriksdottir, Gudny1 aSleegers, Kristel1 aGoate, Alison, M1 aFiévet, Nathalie1 aHuentelman, Matthew, J1 aGill, Michael1 aBrown, Kristelle1 aKamboh, Ilyas1 aKeller, Lina1 aBarberger-Gateau, Pascale1 aMcGuinness, Bernadette1 aLarson, Eric, B1 aMyers, Amanda, J1 aDufouil, Carole1 aTodd, Stephen1 aWallon, David1 aLove, Seth1 aRogaeva, Ekaterina1 aGallacher, John1 aSt George-Hyslop, Peter1 aClarimon, Jordi1 aLleo, Alberto1 aBayer, Anthony1 aTsuang, Debby, W1 aYu, Lei1 aTsolaki, Magda1 aBossù, Paola1 aSpalletta, Gianfranco1 aProitsi, Petra1 aCollinge, John1 aSorbi, Sandro1 aGarcia, Florentino, Sanchez1 aFox, Nick, C1 aHardy, John1 aNaranjo, Maria, Candida De1 aBosco, Paolo1 aClarke, Robert1 aBrayne, Carol1 aGalimberti, Daniela1 aScarpini, Elio1 aBonuccelli, Ubaldo1 aMancuso, Michelangelo1 aSiciliano, Gabriele1 aMoebus, Susanne1 aMecocci, Patrizia1 aDel Zompo, Maria1 aMaier, Wolfgang1 aHampel, Harald1 aPilotto, Alberto1 aFrank-García, Ana1 aPanza, Francesco1 aSolfrizzi, Vincenzo1 aCaffarra, Paolo1 aNacmias, Benedetta1 aPerry, William1 aMayhaus, Manuel1 aLannfelt, Lars1 aHakonarson, Hakon1 aPichler, Sabrina1 aCarrasquillo, Minerva, M1 aIngelsson, Martin1 aBeekly, Duane1 aAlvarez, Victoria1 aZou, Fanggeng1 aValladares, Otto1 aYounkin, Steven, G1 aCoto, Eliecer1 aHamilton-Nelson, Kara, L1 aGu, Wei1 aRazquin, Cristina1 aPastor, Pau1 aMateo, Ignacio1 aOwen, Michael, J1 aFaber, Kelley, M1 aJonsson, Palmi, V1 aCombarros, Onofre1 aO'Donovan, Michael, C1 aCantwell, Laura, B1 aSoininen, Hilkka1 aBlacker, Deborah1 aMead, Simon1 aMosley, Thomas, H1 aBennett, David, A1 aHarris, Tamara, B1 aFratiglioni, Laura1 aHolmes, Clive1 ade Bruijn, Renee, F A G1 aPassmore, Peter1 aMontine, Thomas, J1 aBettens, Karolien1 aRotter, Jerome, I1 aBrice, Alexis1 aMorgan, Kevin1 aForoud, Tatiana, M1 aKukull, Walter, A1 aHannequin, Didier1 aPowell, John, F1 aNalls, Michael, A1 aRitchie, Karen1 aLunetta, Kathryn, L1 aKauwe, John, S K1 aBoerwinkle, Eric1 aRiemenschneider, Matthias1 aBoada, Merce1 aHiltunen, Mikko1 aMartin, Eden, R1 aSchmidt, Reinhold1 aRujescu, Dan1 aDartigues, Jean-François1 aMayeux, Richard1 aTzourio, Christophe1 aHofman, Albert1 aNöthen, Markus, M1 aGraff, Caroline1 aPsaty, Bruce, M1 aHaines, Jonathan, L1 aLathrop, Mark1 aPericak-Vance, Margaret, A1 aLauner, Lenore, J1 aVan Broeckhoven, Christine1 aFarrer, Lindsay, A1 aDuijn, Cornelia, M1 aRamirez, Alfredo1 aSeshadri, Sudha1 aSchellenberg, Gerard, D1 aAmouyel, Philippe1 aWilliams, Julie1 aUnited Kingdom Brain Expression Consortium1 aCardiovascular Health Study (CHS) uhttps://chs-nhlbi.org/node/661717687nas a2205785 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2017 eng d a1546-171800aRare coding variants in PLCG2, ABI3, and TREM2 implicate microglial-mediated innate immunity in Alzheimer's disease.0 aRare coding variants in PLCG2 ABI3 and TREM2 implicate microglia c2017 Sep a1373-13840 v493 aWe identified rare coding variants associated with Alzheimer's disease in a three-stage case-control study of 85,133 subjects. In stage 1, we genotyped 34,174 samples using a whole-exome microarray. In stage 2, we tested associated variants (P < 1 × 10-4) in 35,962 independent samples using de novo genotyping and imputed genotypes. In stage 3, we used an additional 14,997 samples to test the most significant stage 2 associations (P < 5 × 10-8) using imputed genotypes. We observed three new genome-wide significant nonsynonymous variants associated with Alzheimer's disease: a protective variant in PLCG2 (rs72824905: p.Pro522Arg, P = 5.38 × 10-10, odds ratio (OR) = 0.68, minor allele frequency (MAF)cases = 0.0059, MAFcontrols = 0.0093), a risk variant in ABI3 (rs616338: p.Ser209Phe, P = 4.56 × 10-10, OR = 1.43, MAFcases = 0.011, MAFcontrols = 0.008), and a new genome-wide significant variant in TREM2 (rs143332484: p.Arg62His, P = 1.55 × 10-14, OR = 1.67, MAFcases = 0.0143, MAFcontrols = 0.0089), a known susceptibility gene for Alzheimer's disease. These protein-altering changes are in genes highly expressed in microglia and highlight an immune-related protein-protein interaction network enriched for previously identified risk genes in Alzheimer's disease. These genetic findings provide additional evidence that the microglia-mediated innate immune response contributes directly to the development of Alzheimer's disease.
10aAdaptor Proteins, Signal Transducing10aAlzheimer Disease10aAmino Acid Sequence10aCase-Control Studies10aExome10aGene Expression Profiling10aGene Frequency10aGenetic Predisposition to Disease10aGenotype10aHumans10aImmunity, Innate10aLinkage Disequilibrium10aMembrane Glycoproteins10aMicroglia10aOdds Ratio10aPhospholipase C gamma10aPolymorphism, Single Nucleotide10aProtein Interaction Maps10aReceptors, Immunologic10aSequence Homology, Amino Acid1 aSims, Rebecca1 avan der Lee, Sven, J1 aNaj, Adam, C1 aBellenguez, Céline1 aBadarinarayan, Nandini1 aJakobsdottir, Johanna1 aKunkle, Brian, W1 aBoland, Anne1 aRaybould, Rachel1 aBis, Joshua, C1 aMartin, Eden, R1 aGrenier-Boley, Benjamin1 aHeilmann-Heimbach, Stefanie1 aChouraki, Vincent1 aKuzma, Amanda, B1 aSleegers, Kristel1 aVronskaya, Maria1 aRuiz, Agustin1 aGraham, Robert, R1 aOlaso, Robert1 aHoffmann, Per1 aGrove, Megan, L1 aVardarajan, Badri, N1 aHiltunen, Mikko1 aNöthen, Markus, M1 aWhite, Charles, C1 aHamilton-Nelson, Kara, L1 aEpelbaum, Jacques1 aMaier, Wolfgang1 aChoi, Seung-Hoan1 aBeecham, Gary, W1 aDulary, Cécile1 aHerms, Stefan1 aSmith, Albert, V1 aFunk, Cory, C1 aDerbois, Céline1 aForstner, Andreas, J1 aAhmad, Shahzad1 aLi, Hongdong1 aBacq, Delphine1 aHarold, Denise1 aSatizabal, Claudia, L1 aValladares, Otto1 aSquassina, Alessio1 aThomas, Rhodri1 aBrody, Jennifer, A1 aQu, Liming1 aSánchez-Juan, Pascual1 aMorgan, Taniesha1 aWolters, Frank, J1 aZhao, Yi1 aGarcia, Florentino, Sanchez1 aDenning, Nicola1 aFornage, Myriam1 aMalamon, John1 aNaranjo, Maria, Candida De1 aMajounie, Elisa1 aMosley, Thomas, H1 aDombroski, Beth1 aWallon, David1 aLupton, Michelle, K1 aDupuis, Josée1 aWhitehead, Patrice1 aFratiglioni, Laura1 aMedway, Christopher1 aJian, Xueqiu1 aMukherjee, Shubhabrata1 aKeller, Lina1 aBrown, Kristelle1 aLin, Honghuang1 aCantwell, Laura, B1 aPanza, Francesco1 aMcGuinness, Bernadette1 aMoreno-Grau, Sonia1 aBurgess, Jeremy, D1 aSolfrizzi, Vincenzo1 aProitsi, Petra1 aAdams, Hieab, H1 aAllen, Mariet1 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2019 eng d a1546-171800aGenetic meta-analysis of diagnosed Alzheimer's disease identifies new risk loci and implicates Aβ, tau, immunity and lipid processing.0 aGenetic metaanalysis of diagnosed Alzheimers disease identifies c2019 Mar a414-4300 v513 aRisk for late-onset Alzheimer's disease (LOAD), the most prevalent dementia, is partially driven by genetics. To identify LOAD risk loci, we performed a large genome-wide association meta-analysis of clinically diagnosed LOAD (94,437 individuals). We confirm 20 previous LOAD risk loci and identify five new genome-wide loci (IQCK, ACE, ADAM10, ADAMTS1, and WWOX), two of which (ADAM10, ACE) were identified in a recent genome-wide association (GWAS)-by-familial-proxy of Alzheimer's or dementia. Fine-mapping of the human leukocyte antigen (HLA) region confirms the neurological and immune-mediated disease haplotype HLA-DR15 as a risk factor for LOAD. Pathway analysis implicates immunity, lipid metabolism, tau binding proteins, and amyloid precursor protein (APP) metabolism, showing that genetic variants affecting APP and Aβ processing are associated not only with early-onset autosomal dominant Alzheimer's disease but also with LOAD. Analyses of risk genes and pathways show enrichment for rare variants (P = 1.32 × 10), indicating that additional rare variants remain to be identified. We also identify important genetic correlations between LOAD and traits such as family history of dementia and education.
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Jennifer, A1 aDombroski, Beth, A1 aNaranjo, Maria, Candida De1 aDaniilidou, Makrina1 aEiriksdottir, Gudny1 aMukherjee, Shubhabrata1 aWallon, David1 aUphill, James1 aAspelund, Thor1 aCantwell, Laura, B1 aGarzia, Fabienne1 aGalimberti, Daniela1 aHofer, Edith1 aButkiewicz, Mariusz1 aFin, Bertrand1 aScarpini, Elio1 aSarnowski, Chloe1 aBush, Will, S1 aMeslage, Stéphane1 aKornhuber, Johannes1 aWhite, Charles, C1 aSong, Yuenjoo1 aBarber, Robert, C1 aEngelborghs, Sebastiaan1 aSordon, Sabrina1 aVoijnovic, Dina1 aAdams, Perrie, M1 aVandenberghe, Rik1 aMayhaus, Manuel1 aCupples, Adrienne, L1 aAlbert, Marilyn, S1 aDe Deyn, Peter, P1 aGu, Wei1 aHimali, Jayanadra, J1 aBeekly, Duane1 aSquassina, Alessio1 aHartmann, Annette, M1 aOrellana, Adelina1 aBlacker, Deborah1 aRodriguez-Rodriguez, Eloy1 aLovestone, Simon1 aGarcia, Melissa, E1 aDoody, Rachelle, S1 aMunoz-Fernadez, Carmen1 aSussams, Rebecca1 aLin, Honghuang1 aFairchild, Thomas, J1 aBenito, Yolanda, A1 aHolmes, Clive1 aKaramujić-Čomić, Hata1 aFrosch, Matthew, P1 aThonberg, Håkan1 aMaier, Wolfgang1 aRoschupkin, Gena1 aGhetti, Bernardino1 aGiedraitis, Vilmantas1 aKawalia, Amit1 aLi, Shuo1 aHuebinger, Ryan, M1 aKilander, Lena1 aMoebus, Susanne1 aHernandez, Isabel1 aKamboh, Ilyas1 aBrundin, RoseMarie1 aTurton, James1 aYang, Qiong1 aKatz, Mindy, J1 aConcari, Letizia1 aLord, Jenny1 aBeiser, Alexa, S1 aKeene, Dirk1 aHelisalmi, Seppo1 aKloszewska, Iwona1 aKukull, Walter, A1 aKoivisto, Anne, Maria1 aLynch, Aoibhinn1 aTarraga, Lluis1 aLarson, Eric, B1 aHaapasalo, Annakaisa1 aLawlor, Brian1 aMosley, Thomas, H1 aLipton, Richard, B1 aSolfrizzi, Vincenzo1 aGill, Michael1 aLongstreth, W T1 aMontine, Thomas, J1 aFrisardi, Vincenza1 aDiez-Fairen, Monica1 aRivadeneira, Fernando1 aPetersen, Ronald, C1 aDeramecourt, Vincent1 aAlvarez, Ignacio1 aSalani, Francesca1 aCiaramella, Antonio1 aBoerwinkle, Eric1 aReiman, Eric, M1 aFiévet, Nathalie1 aRotter, Jerome, I1 aReisch, Joan, S1 aHanon, Olivier1 aCupidi, Chiara1 aUitterlinden, A, G Andre1 aRoyall, Donald, R1 aDufouil, Carole1 aMaletta, Raffaele, Giovanni1 ade Rojas, Itziar1 aSano, Mary1 aBrice, Alexis1 aCecchetti, Roberta1 aSt George-Hyslop, Peter1 aRitchie, Karen1 aTsolaki, Magda1 aTsuang, Debby, W1 aDubois, Bruno1 aCraig, David1 aWu, Chuang-Kuo1 aSoininen, Hilkka1 aAvramidou, Despoina1 aAlbin, Roger, L1 aFratiglioni, Laura1 aGermanou, Antonia1 aApostolova, Liana, G1 aKeller, Lina1 aKoutroumani, Maria1 aArnold, Steven, E1 aPanza, Francesco1 aGkatzima, Olymbia1 aAsthana, Sanjay1 aHannequin, Didier1 aWhitehead, Patrice1 aAtwood, Craig, S1 aCaffarra, Paolo1 aHampel, Harald1 aQuintela, Inés1 aCarracedo, Angel1 aLannfelt, Lars1 aRubinsztein, David, C1 aBarnes, Lisa, L1 aPasquier, Florence1 aFrölich, Lutz1 aBarral, Sandra1 aMcGuinness, Bernadette1 aBeach, Thomas, G1 aJohnston, Janet, A1 aBecker, James, T1 aPassmore, Peter1 aBigio, Eileen, H1 aSchott, Jonathan, M1 aBird, Thomas, D1 aWarren, Jason, D1 aBoeve, Bradley, F1 aLupton, Michelle, K1 aBowen, James, D1 aProitsi, Petra1 aBoxer, Adam1 aPowell, John, F1 aBurke, James, R1 aKauwe, John, S K1 aBurns, Jeffrey, M1 aMancuso, Michelangelo1 aBuxbaum, Joseph, D1 aBonuccelli, Ubaldo1 aCairns, Nigel, J1 aMcQuillin, Andrew1 aCao, Chuanhai1 aLivingston, Gill1 aCarlson, Chris, S1 aBass, Nicholas, J1 aCarlsson, Cynthia, M1 aHardy, John1 aCarney, Regina, M1 aBras, Jose1 aCarrasquillo, Minerva, M1 aGuerreiro, Rita1 aAllen, Mariet1 aChui, Helena, C1 aFisher, Elizabeth1 aMasullo, Carlo1 aCrocco, Elizabeth, A1 aDeCarli, Charles1 aBisceglio, Gina1 aDick, Malcolm1 aMa, Li1 aDuara, Ranjan1 aGraff-Radford, Neill, R1 aEvans, Denis, A1 aHodges, Angela1 aFaber, Kelley, M1 aScherer, Martin1 aFallon, Kenneth, B1 aRiemenschneider, Matthias1 aFardo, David, W1 aHeun, Reinhard1 aFarlow, Martin, R1 aKölsch, Heike1 aFerris, Steven1 aLeber, Markus1 aForoud, Tatiana, M1 aHeuser, Isabella1 aGalasko, Douglas, R1 aGiegling, Ina1 aGearing, Marla1 aHüll, Michael1 aGeschwind, Daniel, H1 aGilbert, John, R1 aMorris, John1 aGreen, Robert, C1 aMayo, 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aHooper, Nigel, M1 aMcCormick, Wayne, C1 aDaniele, Antonio1 aMcCurry, Susan, M1 aBayer, Anthony1 aMcDavid, Andrew, N1 aGallacher, John1 aMcKee, Ann, C1 avan den Bussche, Hendrik1 aMesulam, Marsel1 aBrayne, Carol1 aMiller, Bruce, L1 aRiedel-Heller, Steffi1 aMiller, Carol, A1 aMiller, Joshua, W1 aAl-Chalabi, Ammar1 aMorris, John, C1 aShaw, Christopher, E1 aMyers, Amanda, J1 aWiltfang, Jens1 aO'Bryant, Sid1 aOlichney, John, M1 aAlvarez, Victoria1 aParisi, Joseph, E1 aSingleton, Andrew, B1 aPaulson, Henry, L1 aCollinge, John1 aPerry, William, R1 aMead, Simon1 aPeskind, Elaine1 aCribbs, David, H1 aRossor, Martin1 aPierce, Aimee1 aRyan, Natalie, S1 aPoon, Wayne, W1 aNacmias, Benedetta1 aPotter, Huntington1 aSorbi, Sandro1 aQuinn, Joseph, F1 aSacchinelli, Eleonora1 aRaj, Ashok1 aSpalletta, Gianfranco1 aRaskind, Murray1 aCaltagirone, Carlo1 aBossù, Paola1 aOrfei, Maria, Donata1 aReisberg, Barry1 aClarke, Robert1 aReitz, Christiane1 aSmith, David1 aRingman, John, M1 aWarden, Donald1 aRoberson, 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aLambert, Jean-Charles1 aPericak-Vance, Margaret, A1 aAlzheimer Disease Genetics Consortium (ADGC),1 aEuropean Alzheimer’s Disease Initiative (EADI),1 aCohorts for Heart and Aging Research in Genomic Epidemiology Consortium (CHARGE),1 aGenetic and Environmental Risk in AD/Defining Genetic, Polygenic and Environmental Risk for Alzheimer’s Disease Consortium (GERAD/PERADES), uhttps://chs-nhlbi.org/node/7977