03016nas a2200325 4500008004100000022001400041245006000055210005600115260001700171300001200188490000700200520212400207653001002331653001802341653002402359653002302383653001102406653004002417653003102457653002702488100001902515700002002534700001502554700001702569700001402586700002102600700001702621700001602638856003602654 1998 eng d a0195-610800aA brain image database for structure/function analysis.0 abrain image database for structurefunction analysis c1998 Nov-Dec a1869-770 v193 a

BACKGROUND AND PURPOSE: Lesion-deficit-based structure-function analysis has traditionally been empirical and nonquantitative. Our purpose was to establish a new brain image database (BRAID) that allows the statistical correlation of brain functional measures with anatomic lesions revealed by clinical brain images.

METHODS: Data on 303 participants in the MR Feasibility Study of the Cardiovascular Health Study were tested for lesion/deficit correlations. Functional data were derived from a limited neurologic examination performed at the time of the MR examination. Image data included 3D lesion descriptions derived from the MR examinations by hand segmentation. MR images were normalized in-plane using local, linear Talairach normalization. A database was implemented to support spatial data structures and associated geometric and statistical operations. The database stored the segmented lesions, patient functional scores, and several anatomic atlases. Lesion-deficit association was sought by contingency testing (chi2-test) for every possible combination of each neurologic variable and each labeled atlas structure. Significant associations that confirmed accepted lesion-deficit relationships were sought.

RESULTS: Two-hundred thirty-five infarctlike lesions in 117 subjects were viewed collectively after mapping into Talairach cartesian coordinates. Anatomic structures most strongly correlated with neurologic deficits tended to be situated in anatomically appropriate areas. For example, infarctlike lesions associated with visual field defects were correlated with structures in contralateral occipital structures, including the optic radiations and occipital gyri.

CONCLUSION: Known lesion-deficit correlations can be established by a database using a standard coordinate system for representing spatial data and incorporating functional and structural data together with appropriate query mechanisms. Improvements and further applications of this methodology may provide a powerful technique for uncovering new structure-function relationships.

10aBrain10aBrain Mapping10aCerebral Infarction10aDatabases as Topic10aHumans10aImage Processing, Computer-Assisted10aMagnetic Resonance Imaging10aNeurologic Examination1 aLetovsky, S, I1 aWhitehead, S, H1 aPaik, C, H1 aMiller, G, A1 aGerber, J1 aHerskovits, E, H1 aFulton, T, K1 aBryan, R, N uhttps://chs-nhlbi.org/node/1519