05294nas a2201225 4500008004100000022001400041245011300055210006900168260000900237300001200246490000600258520192600264653001002190653003202200653001102232653003102243653001702274653003402291653001102325653002502336653000902361653001602370100001602386700002102402700001802423700002602441700002302467700001702490700002002507700002102527700002002548700002402568700002302592700002202615700002102637700002202658700002402680700002302704700001802727700002402745700002302769700001702792700002202809700002102831700001902852700001702871700001802888700001902906700001502925700001902940700002302959700001302982700001802995700001703013700002103030700002203051700001903073700001903092700002003111700001603131700002103147700001603168700002803184700001803212700001903230700001203249700001503261700002203276700001703298700001703315700001903332700002203351700001903373700002203392700002403414700001503438700001903453700002003472700002903492700002003521700002603541700002203567700001903589700002003608700001703628700001903645700002303664700002203687700002803709700001903737700001903756700002003775700002103795700001903816700001903835700002303854700002303877700002503900700002003925700002103945700002403966700001703990700002504007856003604032 2014 eng d a1932-620300aLarge-scale genome-wide association studies and meta-analyses of longitudinal change in adult lung function.0 aLargescale genomewide association studies and metaanalyses of lo c2014 ae1007760 v93 a
BACKGROUND: Genome-wide association studies (GWAS) have identified numerous loci influencing cross-sectional lung function, but less is known about genes influencing longitudinal change in lung function.
METHODS: We performed GWAS of the rate of change in forced expiratory volume in the first second (FEV1) in 14 longitudinal, population-based cohort studies comprising 27,249 adults of European ancestry using linear mixed effects model and combined cohort-specific results using fixed effect meta-analysis to identify novel genetic loci associated with longitudinal change in lung function. Gene expression analyses were subsequently performed for identified genetic loci. As a secondary aim, we estimated the mean rate of decline in FEV1 by smoking pattern, irrespective of genotypes, across these 14 studies using meta-analysis.
RESULTS: The overall meta-analysis produced suggestive evidence for association at the novel IL16/STARD5/TMC3 locus on chromosome 15 (P = 5.71 × 10(-7)). In addition, meta-analysis using the five cohorts with ≥3 FEV1 measurements per participant identified the novel ME3 locus on chromosome 11 (P = 2.18 × 10(-8)) at genome-wide significance. Neither locus was associated with FEV1 decline in two additional cohort studies. We confirmed gene expression of IL16, STARD5, and ME3 in multiple lung tissues. Publicly available microarray data confirmed differential expression of all three genes in lung samples from COPD patients compared with controls. Irrespective of genotypes, the combined estimate for FEV1 decline was 26.9, 29.2 and 35.7 mL/year in never, former, and persistent smokers, respectively.
CONCLUSIONS: In this large-scale GWAS, we identified two novel genetic loci in association with the rate of change in FEV1 that harbor candidate genes with biologically plausible functional links to lung function.
10aAdult10aChromosomes, Human, Pair 1110aFemale10aGene Expression Regulation10aGenetic Loci10aGenome-Wide Association Study10aHumans10aLongitudinal Studies10aMale10aRespiration1 aTang, Wenbo1 aKowgier, Matthew1 aLoth, Daan, W1 aArtigas, Maria, Soler1 aJoubert, Bonnie, R1 aHodge, Emily1 aGharib, Sina, A1 aSmith, Albert, V1 aRuczinski, Ingo1 aGudnason, Vilmundur1 aMathias, Rasika, A1 aHarris, Tamara, B1 aHansel, Nadia, N1 aLauner, Lenore, J1 aBarnes, Kathleen, C1 aHansen, Joyanna, G1 aAlbrecht, Eva1 aAldrich, Melinda, C1 aAllerhand, Michael1 aBarr, Graham1 aBrusselle, Guy, G1 aCouper, David, J1 aCurjuric, Ivan1 aDavies, Gail1 aDeary, Ian, J1 aDupuis, Josée1 aFall, Tove1 aFoy, Millennia1 aFranceschini, Nora1 aGao, Wei1 aGläser, Sven1 aGu, Xiangjun1 aHancock, Dana, B1 aHeinrich, Joachim1 aHofman, Albert1 aImboden, Medea1 aIngelsson, Erik1 aJames, Alan1 aKarrasch, Stefan1 aKoch, Beate1 aKritchevsky, Stephen, B1 aKumar, Ashish1 aLahousse, Lies1 aLi, Guo1 aLind, Lars1 aLindgren, Cecilia1 aLiu, Yongmei1 aLohman, Kurt1 aLumley, Thomas1 aMcArdle, Wendy, L1 aMeibohm, Bernd1 aMorris, Andrew, P1 aMorrison, Alanna, C1 aMusk, Bill1 aNorth, Kari, E1 aPalmer, Lyle, J1 aProbst-Hensch, Nicole, M1 aPsaty, Bruce, M1 aRivadeneira, Fernando1 aRotter, Jerome, I1 aSchulz, Holger1 aSmith, Lewis, J1 aSood, Akshay1 aStarr, John, M1 aStrachan, David, P1 aTeumer, Alexander1 aUitterlinden, André, G1 aVölzke, Henry1 aVoorman, Arend1 aWain, Louise, V1 aWells, Martin, T1 aWilk, Jemma, B1 aWilliams, Dale1 aHeckbert, Susan, R1 aStricker, Bruno, H1 aLondon, Stephanie, J1 aFornage, Myriam1 aTobin, Martin, D1 aO'Connor, George, T1 aHall, Ian, P1 aCassano, Patricia, A uhttps://chs-nhlbi.org/node/660406988nas a2201993 4500008004100000022001400041245011600055210006900171260001600240520137500256100001201631700001301643700001801656700002201674700002201696700002501718700001801743700002701761700002001788700002801808700001901836700002001855700002101875700001801896700001601914700002801930700001901958700002501977700002302002700002302025700002302048700002502071700001902096700002102115700002102136700002202157700002102179700002302200700001502223700001802238700001902256700002102275700001702296700001702313700001602330700002002346700002802366700001802394700001902412700002002431700001702451700001802468700001802486700002202504700002102526700002102547700002902568700002302597700002202620700001702642700002202659700003202681700002102713700002302734700002102757700003102778700001402809700002202823700001902845700001602864700002102880700002102901700002302922700002302945700002402968700001902992700002103011700002303032700002103055700002003076700002403096700001803120700001703138700002003155700001803175700002003193700002403213700002103237700002103258700002503279700002203304700001603326700002103342700001703363700002203380700002303402700002003425700001803445700002403463700002203487700002203509700001903531700001903550700001703569700002803586700002403614700002303638700002503661700002003686700002403706700002103730700002403751700002203775700002203797700002303819700002203842700001703864700002103881700002103902700001703923700002003940700001803960700002503978700001904003700002104022700001904043700002004062700002104082700002504103700001804128700001904146700002004165700001904185700001904204700002004223700002904243700002004272700001104292700002304303700002004326700001904346700002004365700002604385700002404411700001904435700002104454700002004475700002404495700002104519700002304540700002804563700001804591700002304609700001704632700001904649700002604668700001904694700001904713700001804732700002304750700002104773700002304794700002304817700001904840700001904859710003904878710004104917856003604958 2016 eng d a1533-345000aSOS2 and ACP1 Loci Identified through Large-Scale Exome Chip Analysis Regulate Kidney Development and Function.0 aSOS2 and ACP1 Loci Identified through LargeScale Exome Chip Anal c2016 Dec 053 aGenome-wide association studies have identified >50 common variants associated with kidney function, but these variants do not fully explain the variation in eGFR. We performed a two-stage meta-analysis of associations between genotypes from the Illumina exome array and eGFR on the basis of serum creatinine (eGFRcrea) among participants of European ancestry from the CKDGen Consortium (nStage1: 111,666; nStage2: 48,343). In single-variant analyses, we identified single nucleotide polymorphisms at seven new loci associated with eGFRcrea (PPM1J, EDEM3, ACP1, SPEG, EYA4, CYP1A1, and ATXN2L; PStage1<3.7×10(-7)), of which most were common and annotated as nonsynonymous variants. Gene-based analysis identified associations of functional rare variants in three genes with eGFRcrea, including a novel association with the SOS Ras/Rho guanine nucleotide exchange factor 2 gene, SOS2 (P=5.4×10(-8) by sequence kernel association test). Experimental follow-up in zebrafish embryos revealed changes in glomerular gene expression and renal tubule morphology in the embryonic kidney of acp1- and sos2-knockdowns. These developmental abnormalities associated with altered blood clearance rate and heightened prevalence of edema. This study expands the number of loci associated with kidney function and identifies novel genes with potential roles in kidney formation.
1 aLi, Man1 aLi, Yong1 aWeeks, Olivia1 aMijatovic, Vladan1 aTeumer, Alexander1 aHuffman, Jennifer, E1 aTromp, Gerard1 aFuchsberger, Christian1 aGorski, Mathias1 aLyytikäinen, Leo-Pekka1 aNutile, Teresa1 aSedaghat, Sanaz1 aSorice, Rossella1 aTin, Adrienne1 aYang, Qiong1 aAhluwalia, Tarunveer, S1 aArking, Dan, E1 aBihlmeyer, Nathan, A1 aBöger, Carsten, A1 aCarroll, Robert, J1 aChasman, Daniel, I1 aCornelis, Marilyn, C1 aDehghan, Abbas1 aFaul, Jessica, D1 aFeitosa, Mary, F1 aGambaro, Giovanni1 aGasparini, Paolo1 aGiulianini, Franco1 aHeid, Iris1 aHuang, Jinyan1 aImboden, Medea1 aJackson, Anne, U1 aJeff, Janina1 aJhun, Min, A1 aKatz, Ronit1 aKifley, Annette1 aKilpeläinen, Tuomas, O1 aKumar, Ashish1 aLaakso, Markku1 aLi-Gao, Ruifang1 aLohman, Kurt1 aLu, Yingchang1 aMägi, Reedik1 aMalerba, Giovanni1 aMihailov, Evelin1 aMohlke, Karen, L1 aMook-Kanamori, Dennis, O1 aRobino, Antonietta1 aRuderfer, Douglas1 aSalvi, Erika1 aSchick, Ursula, M1 aSchulz, Christina-Alexandra1 aSmith, Albert, V1 aSmith, Jennifer, A1 aTraglia, Michela1 aYerges-Armstrong, Laura, M1 aZhao, Wei1 aGoodarzi, Mark, O1 aKraja, Aldi, T1 aLiu, Chunyu1 aWessel, Jennifer1 aBoerwinkle, Eric1 aBorecki, Ingrid, B1 aBork-Jensen, Jette1 aBottinger, Erwin, P1 aBraga, Daniele1 aBrandslund, Ivan1 aBrody, Jennifer, A1 aCampbell, Archie1 aCarey, David, J1 aChristensen, Cramer1 aCoresh, Josef1 aCrook, Errol1 aCurhan, Gary, C1 aCusi, Daniele1 ade Boer, Ian, H1 ade Vries, Aiko, P J1 aDenny, Joshua, C1 aDevuyst, Olivier1 aDreisbach, Albert, W1 aEndlich, Karlhans1 aEsko, Tõnu1 aFranco, Oscar, H1 aFulop, Tibor1 aGerhard, Glenn, S1 aGlümer, Charlotte1 aGottesman, Omri1 aGrarup, Niels1 aGudnason, Vilmundur1 aHarris, Tamara, B1 aHayward, Caroline1 aHocking, Lynne1 aHofman, Albert1 aHu, Frank, B1 aHusemoen, Lise, Lotte N1 aJackson, Rebecca, D1 aJørgensen, Torben1 aJørgensen, Marit, E1 aKähönen, Mika1 aKardia, Sharon, L R1 aKönig, Wolfgang1 aKooperberg, Charles1 aKriebel, Jennifer1 aLauner, Lenore, J1 aLauritzen, Torsten1 aLehtimäki, Terho1 aLevy, Daniel1 aLinksted, Pamela1 aLinneberg, Allan1 aLiu, Yongmei1 aLoos, Ruth, J F1 aLupo, Antonio1 aMeisinger, Christine1 aMelander, Olle1 aMetspalu, Andres1 aMitchell, Paul1 aNauck, Matthias1 aNürnberg, Peter1 aOrho-Melander, Marju1 aParsa, Afshin1 aPedersen, Oluf1 aPeters, Annette1 aPeters, Ulrike1 aPolasek, Ozren1 aPorteous, David1 aProbst-Hensch, Nicole, M1 aPsaty, Bruce, M1 aQi, Lu1 aRaitakari, Olli, T1 aReiner, Alex, P1 aRettig, Rainer1 aRidker, Paul, M1 aRivadeneira, Fernando1 aRossouw, Jacques, E1 aSchmidt, Frank1 aSiscovick, David1 aSoranzo, Nicole1 aStrauch, Konstantin1 aToniolo, Daniela1 aTurner, Stephen, T1 aUitterlinden, André, G1 aUlivi, Sheila1 aVelayutham, Dinesh1 aVölker, Uwe1 aVölzke, Henry1 aWaldenberger, Melanie1 aWang, Jie, Jin1 aWeir, David, R1 aWitte, Daniel1 aKuivaniemi, Helena1 aFox, Caroline, S1 aFranceschini, Nora1 aGoessling, Wolfram1 aKöttgen, Anna1 aChu, Audrey, Y1 aCHARGE Glycemic-T2D Working Group,1 aCHARGE Blood Pressure Working Group, uhttps://chs-nhlbi.org/node/725505089nas a2201429 4500008004100000022001400041245009100055210006900146260000900215300000600224490000600230520111900236100002501355700002601380700002001406700002101426700002001447700002001467700001901487700002501506700001301531700002001544700002301564700002501587700002801612700001801640700001201658700002401670700002101694700002101715700002101736700002301757700002001780700002401800700002001824700001901844700001901863700002201882700001601904700002801920700002401948700002301972700002401995700002302019700001802042700001602060700001602076700001702092700001602109700001702125700002302142700002502165700002102190700002102211700001802232700002102250700002502271700002002296700001702316700002402333700002602357700002202383700001902405700001502424700002202439700001802461700001802479700002002497700001902517700002002536700002302556700001202579700002002591700002802611700001702639700001602656700002402672700001902696700001902715700001902734700002102753700001902774700002102793700002902814700001902843700002002862700002802882700001802910700002302928700002402951700001902975700002002994700001603014700002003030700002403050700001903074700002203093700001903115700002403134700002103158700002403179700002203203700001603225700001803241700001703259700002303276700002003299700002203319700002003341700002603361700001803387700002403405700002203429700002303451700001903474700002403493700001703517700002103534700002503555710004303580856003603623 2018 eng d a2398-502X00aMeta-analysis of exome array data identifies six novel genetic loci for lung function.0 aMetaanalysis of exome array data identifies six novel genetic lo c2018 a40 v33 aOver 90 regions of the genome have been associated with lung function to date, many of which have also been implicated in chronic obstructive pulmonary disease. We carried out meta-analyses of exome array data and three lung function measures: forced expiratory volume in one second (FEV ), forced vital capacity (FVC) and the ratio of FEV to FVC (FEV /FVC). These analyses by the SpiroMeta and CHARGE consortia included 60,749 individuals of European ancestry from 23 studies, and 7,721 individuals of African Ancestry from 5 studies in the discovery stage, with follow-up in up to 111,556 independent individuals. We identified significant (P<2·8x10 ) associations with six SNPs: a nonsynonymous variant in , which is predicted to be damaging, three intronic SNPs ( and ) and two intergenic SNPs near to and Expression quantitative trait loci analyses found evidence for regulation of gene expression at three signals and implicated several genes, including and . Further interrogation of these loci could provide greater understanding of the determinants of lung function and pulmonary disease.
1 aJackson, Victoria, E1 aLatourelle, Jeanne, C1 aWain, Louise, V1 aSmith, Albert, V1 aGrove, Megan, L1 aBartz, Traci, M1 aObeidat, Ma'en1 aProvince, Michael, A1 aGao, Wei1 aQaiser, Beenish1 aPorteous, David, J1 aCassano, Patricia, A1 aAhluwalia, Tarunveer, S1 aGrarup, Niels1 aLi, Jin1 aAltmaier, Elisabeth1 aMarten, Jonathan1 aHarris, Sarah, E1 aManichaikul, Ani1 aPottinger, Tess, D1 aLi-Gao, Ruifang1 aLind-Thomsen, Allan1 aMahajan, Anubha1 aLahousse, Lies1 aImboden, Medea1 aTeumer, Alexander1 aPrins, Bram1 aLyytikäinen, Leo-Pekka1 aEiriksdottir, Gudny1 aFranceschini, Nora1 aSitlani, Colleen, M1 aBrody, Jennifer, A1 aBossé, Yohan1 aTimens, Wim1 aKraja, Aldi1 aLoukola, Anu1 aTang, Wenbo1 aLiu, Yongmei1 aBork-Jensen, Jette1 aJustesen, Johanne, M1 aLinneberg, Allan1 aLange, Leslie, A1 aRawal, Rajesh1 aKarrasch, Stefan1 aHuffman, Jennifer, E1 aSmith, Blair, H1 aDavies, Gail1 aBurkart, Kristin, M1 aMychaleckyj, Josyf, C1 aBonten, Tobias, N1 aEnroth, Stefan1 aLind, Lars1 aBrusselle, Guy, G1 aKumar, Ashish1 aStubbe, Beate1 aKähönen, Mika1 aWyss, Annah, B1 aPsaty, Bruce, M1 aHeckbert, Susan, R1 aHao, Ke1 aRantanen, Taina1 aKritchevsky, Stephen, B1 aLohman, Kurt1 aSkaaby, Tea1 aPisinger, Charlotta1 aHansen, Torben1 aSchulz, Holger1 aPolasek, Ozren1 aCampbell, Archie1 aStarr, John, M1 aRich, Stephen, S1 aMook-Kanamori, Dennis, O1 aJohansson, Asa1 aIngelsson, Erik1 aUitterlinden, André, G1 aWeiss, Stefan1 aRaitakari, Olli, T1 aGudnason, Vilmundur1 aNorth, Kari, E1 aGharib, Sina, A1 aSin, Don, D1 aTaylor, Kent, D1 aO'Connor, George, T1 aKaprio, Jaakko1 aHarris, Tamara, B1 aPederson, Oluf1 aVestergaard, Henrik1 aWilson, James, G1 aStrauch, Konstantin1 aHayward, Caroline1 aKerr, Shona1 aDeary, Ian, J1 aBarr, Graham1 ade Mutsert, Renée1 aGyllensten, Ulf1 aMorris, Andrew, P1 aIkram, Arfan, M1 aProbst-Hensch, Nicole1 aGläser, Sven1 aZeggini, Eleftheria1 aLehtimäki, Terho1 aStrachan, David, P1 aDupuis, Josée1 aMorrison, Alanna, C1 aHall, Ian, P1 aTobin, Martin, D1 aLondon, Stephanie, J1 aUnderstanding Society Scientific Group uhttps://chs-nhlbi.org/node/779507136nas a2202245 4500008004100000022001400041245011700055210006900172260001300241300001000254490000700264520074900271100002301020700003301043700002401076700002601100700002301126700001301149700001701162700002001179700002101199700001701220700001901237700003201256700002101288700002301309700002301332700002501355700003101380700002101411700002201432700002201454700002401476700001701500700002201517700002101539700003101560700002001591700002001611700001801631700002501649700003101674700002501705700002101730700001701751700002301768700002001791700002101811700002101832700002401853700002201877700001801899700001901917700002001936700001801956700001801974700002001992700002102012700002002033700002402053700002802077700001902105700002302124700001902147700002202166700002402188700002002212700002102232700002002253700002402273700001902297700001802316700002002334700002202354700001602376700001902392700002102411700002502432700001602457700002102473700002702494700002002521700001802541700002502559700002202584700002102606700002002627700002102647700002602668700002402694700002502718700002402743700001902767700001902786700001802805700001802823700002102841700001902862700002002881700002302901700001802924700001702942700001802959700002202977700002302999700002103022700001203043700001803055700002003073700002503093700001803118700002103136700002003157700002603177700002503203700002303228700002103251700001803272700002203290700001703312700001703329700002003346700001703366700002003383700002003403700002103423700003003444700001903474700002403493700002603517700002303543700001903566700001903585700002203604700002203626700002203648700002203670700002603692700002303718700002203741700002303763700002603786700002103812700002403833700002103857700002303878700002003901700002203921700001803943700002603961700002203987700002004009700002104029700002004050700002204070700001804092700002104110700002304131700002304154700002304177700002404200700002504224700002804249700002404277700002304301700002304324700002804347700002804375700001904403700002204422700002104444700002204465700002004487700002004507700002104527700002004548700002004568700002004588700002104608700002304629700002004652700002104672700001904693700001904712700002304731700001704754700002004771710006304791856003604854 2018 eng d a1546-171800aMultiancestry association study identifies new asthma risk loci that colocalize with immune-cell enhancer marks.0 aMultiancestry association study identifies new asthma risk loci c2018 Jan a42-530 v503 aWe examined common variation in asthma risk by conducting a meta-analysis of worldwide asthma genome-wide association studies (23,948 asthma cases, 118,538 controls) of individuals from ethnically diverse populations. We identified five new asthma loci, found two new associations at two known asthma loci, established asthma associations at two loci previously implicated in the comorbidity of asthma plus hay fever, and confirmed nine known loci. Investigation of pleiotropy showed large overlaps in genetic variants with autoimmune and inflammatory diseases. The enrichment in enhancer marks at asthma risk loci, especially in immune cells, suggested a major role of these loci in the regulation of immunologically related mechanisms.
1 aDemenais, Florence1 aMargaritte-Jeannin, Patricia1 aBarnes, Kathleen, C1 aCookson, William, O C1 aAltmüller, Janine1 aAng, Wei1 aBarr, Graham1 aBeaty, Terri, H1 aBecker, Allan, B1 aBeilby, John1 aBisgaard, Hans1 aBjornsdottir, Unnur, Steina1 aBleecker, Eugene1 aBønnelykke, Klaus1 aBoomsma, Dorret, I1 aBouzigon, Emmanuelle1 aBrightling, Christopher, E1 aBrossard, Myriam1 aBrusselle, Guy, G1 aBurchard, Esteban1 aBurkart, Kristin, M1 aBush, Andrew1 aChan-Yeung, Moira1 aChung, Kian, Fan1 aAlves, Alexessander, Couto1 aCurtin, John, A1 aCustovic, Adnan1 aDaley, Denise1 ade Jongste, Johan, C1 aDel-Rio-Navarro, Blanca, E1 aDonohue, Kathleen, M1 aDuijts, Liesbeth1 aEng, Celeste1 aEriksson, Johan, G1 aFarrall, Martin1 aFedorova, Yuliya1 aFeenstra, Bjarke1 aFerreira, Manuel, A1 aFreidin, Maxim, B1 aGajdos, Zofia1 aGauderman, Jim1 aGehring, Ulrike1 aGeller, Frank1 aGenuneit, Jon1 aGharib, Sina, A1 aGilliland, Frank1 aGranell, Raquel1 aGraves, Penelope, E1 aGudbjartsson, Daniel, F1 aHaahtela, Tari1 aHeckbert, Susan, R1 aHeederik, Dick1 aHeinrich, Joachim1 aHeliövaara, Markku1 aHenderson, John1 aHimes, Blanca, E1 aHirose, Hiroshi1 aHirschhorn, Joel, N1 aHofman, Albert1 aHolt, Patrick1 aHottenga, Jouke1 aHudson, Thomas, J1 aHui, Jennie1 aImboden, Medea1 aIvanov, Vladimir1 aJaddoe, Vincent, W V1 aJames, Alan1 aJanson, Christer1 aJarvelin, Marjo-Riitta1 aJarvis, Deborah1 aJones, Graham1 aJonsdottir, Ingileif1 aJousilahti, Pekka1 aKabesch, Michael1 aKähönen, Mika1 aKantor, David, B1 aKarunas, Alexandra, S1 aKhusnutdinova, Elza1 aKoppelman, Gerard, H1 aKozyrskyj, Anita, L1 aKreiner, Eskil1 aKubo, Michiaki1 aKumar, Rajesh1 aKumar, Ashish1 aKuokkanen, Mikko1 aLahousse, Lies1 aLaitinen, Tarja1 aLaprise, Catherine1 aLathrop, Mark1 aLau, Susanne1 aLee, Young-Ae1 aLehtimäki, Terho1 aLetort, Sébastien1 aLevin, Albert, M1 aLi, Guo1 aLiang, Liming1 aLoehr, Laura, R1 aLondon, Stephanie, J1 aLoth, Daan, W1 aManichaikul, Ani1 aMarenholz, Ingo1 aMartinez, Fernando, J1 aMatheson, Melanie, C1 aMathias, Rasika, A1 aMatsumoto, Kenji1 aMbarek, Hamdi1 aMcArdle, Wendy, L1 aMelbye, Mads1 aMelén, Erik1 aMeyers, Deborah1 aMichel, Sven1 aMohamdi, Hamida1 aMusk, Arthur, W1 aMyers, Rachel, A1 aNieuwenhuis, Maartje, A E1 aNoguchi, Emiko1 aO'Connor, George, T1 aOgorodova, Ludmila, M1 aPalmer, Cameron, D1 aPalotie, Aarno1 aPark, Julie, E1 aPennell, Craig, E1 aPershagen, Göran1 aPolonikov, Alexey1 aPostma, Dirkje, S1 aProbst-Hensch, Nicole1 aPuzyrev, Valery, P1 aRaby, Benjamin, A1 aRaitakari, Olli, T1 aRamasamy, Adaikalavan1 aRich, Stephen, S1 aRobertson, Colin, F1 aRomieu, Isabelle1 aSalam, Muhammad, T1 aSalomaa, Veikko1 aSchlünssen, Vivi1 aScott, Robert1 aSelivanova, Polina, A1 aSigsgaard, Torben1 aSimpson, Angela1 aSiroux, Valérie1 aSmith, Lewis, J1 aSolodilova, Maria1 aStandl, Marie1 aStefansson, Kari1 aStrachan, David, P1 aStricker, Bruno, H1 aTakahashi, Atsushi1 aThompson, Philip, J1 aThorleifsson, Gudmar1 aThorsteinsdottir, Unnur1 aTiesler, Carla, M T1 aTorgerson, Dara, G1 aTsunoda, Tatsuhiko1 aUitterlinden, André, G1 avan der Valk, Ralf, J P1 aVaysse, Amaury1 aVedantam, Sailaja1 avon Berg, Andrea1 avon Mutius, Erika1 aVonk, Judith, M1 aWaage, Johannes1 aWareham, Nick, J1 aWeiss, Scott, T1 aWhite, Wendy, B1 aWickman, Magnus1 aWiden, Elisabeth1 aWillemsen, Gonneke1 aWilliams, Keoki1 aWouters, Inge, M1 aYang, James, J1 aZhao, Jing Hua1 aMoffatt, Miriam, F1 aOber, Carole1 aNicolae, Dan, L1 aAustralian Asthma Genetics Consortium (AAGC) collaborators uhttps://chs-nhlbi.org/node/7558