05324nas a2201021 4500008004100000022001400041245012300055210006900178260001300247300001100260490000800271520242700279653001002706653002002716653001902736653001902755653002802774653000902802653002102811653001802832653004002850653002902890653001102919653003302930653003802963653001103001653000903012653001603021653001203037653003603049653001003085653001603095100002203111700002003133700002003153700002003173700001903193700002403212700001703236700002103253700002503274700002103299700001803320700002503338700001903363700002003382700002403402700001803426700002803444700003103472700001903503700001903522700002403541700001603565700002303581700001503604700001903619700002203638700002303660700001903683700002003702700002003722700001803742700002503760700002403785700002003809700002203829700002403851700002303875700002303898700002203921700002003943700002403963700002503987700002104012700002104033700001904054700002004073700002004093700002304113700002504136700001904161700002104180700002204201700002204223700002104245856003604266 2015 eng d a1938-320700aHabitual sleep duration is associated with BMI and macronutrient intake and may be modified by CLOCK genetic variants.0 aHabitual sleep duration is associated with BMI and macronutrient c2015 Jan a135-430 v1013 a
BACKGROUND: Short sleep duration has been associated with greater risks of obesity, hypertension, diabetes, and cardiovascular disease. Also, common genetic variants in the human Circadian Locomotor Output Cycles Kaput (CLOCK) show associations with ghrelin and total energy intake.
OBJECTIVES: We examined associations between habitual sleep duration, body mass index (BMI), and macronutrient intake and assessed whether CLOCK variants modify these associations.
DESIGN: We conducted inverse-variance weighted, fixed-effect meta-analyses of results of adjusted associations of sleep duration and BMI and macronutrient intake as percentages of total energy as well as interactions with CLOCK variants from 9 cohort studies including up to 14,906 participants of European descent from the Cohorts for Heart and Aging Research in Genomic Epidemiology Consortium.
RESULTS: We observed a significant association between sleep duration and lower BMI (β ± SE = 0.16 ± 0.04, P < 0.0001) in the overall sample; however, associations between sleep duration and relative macronutrient intake were evident in age- and sex-stratified analyses only. We observed a significant association between sleep duration and lower saturated fatty acid intake in younger (aged 20-64 y) adults (men: 0.11 ± 0.06%, P = 0.03; women: 0.10 ± 0.05%, P = 0.04) and with lower carbohydrate (-0.31 ± 0.12%, P < 0.01), higher total fat (0.18 ± 0.09%, P = 0.05), and higher PUFA (0.05 ± 0.02%, P = 0.02) intakes in older (aged 65-80 y) women. In addition, the following 2 nominally significant interactions were observed: between sleep duration and rs12649507 on PUFA intake and between sleep duration and rs6858749 on protein intake.
CONCLUSIONS: Our results indicate that longer habitual sleep duration is associated with lower BMI and age- and sex-specific favorable dietary behaviors. Differences in the relative intake of specific macronutrients associated with short sleep duration could, at least in part, explain previously reported associations between short sleep duration and chronic metabolic abnormalities. In addition, the influence of obesity-associated CLOCK variants on the association between sleep duration and macronutrient intake suggests that longer habitual sleep duration could ameliorate the genetic predisposition to obesity via a favorable dietary profile.
10aAdult10aBody Mass Index10aCLOCK Proteins10aCohort Studies10aCross-Sectional Studies10aDiet10aDietary Proteins10aEnergy Intake10aEuropean Continental Ancestry Group10aFatty Acids, Unsaturated10aFemale10aGene-Environment Interaction10aGenetic Predisposition to Disease10aHumans10aMale10aMiddle Aged10aObesity10aPolymorphism, Single Nucleotide10aSleep10aYoung Adult1 aDashti, Hassan, S1 aFollis, Jack, L1 aSmith, Caren, E1 aTanaka, Toshiko1 aCade, Brian, E1 aGottlieb, Daniel, J1 aHruby, Adela1 aJacques, Paul, F1 aLamon-Fava, Stefania1 aRichardson, Kris1 aSaxena, Richa1 aScheer, Frank, A J L1 aKovanen, Leena1 aBartz, Traci, M1 aPerälä, Mia-Maria1 aJonsson, Anna1 aFrazier-Wood, Alexis, C1 aKalafati, Ioanna-Panagiota1 aMikkilä, Vera1 aPartonen, Timo1 aLemaitre, Rozenn, N1 aLahti, Jari1 aHernandez, Dena, G1 aToft, Ulla1 aJohnson, Craig1 aKanoni, Stavroula1 aRaitakari, Olli, T1 aPerola, Markus1 aPsaty, Bruce, M1 aFerrucci, Luigi1 aGrarup, Niels1 aHighland, Heather, M1 aRallidis, Loukianos1 aKähönen, Mika1 aHavulinna, Aki, S1 aSiscovick, David, S1 aRäikkönen, Katri1 aJørgensen, Torben1 aRotter, Jerome, I1 aDeloukas, Panos1 aViikari, Jorma, S A1 aMozaffarian, Dariush1 aLinneberg, Allan1 aSeppälä, Ilkka1 aHansen, Torben1 aSalomaa, Veikko1 aGharib, Sina, A1 aEriksson, Johan, G1 aBandinelli, Stefania1 aPedersen, Oluf1 aRich, Stephen, S1 aDedoussis, George1 aLehtimäki, Terho1 aOrdovas, Jose, M uhttps://chs-nhlbi.org/node/661404016nas a2200865 4500008004100000022001400041245009800055210006900153260001600222520147500238100002001713700002001733700002201753700002001775700002201795700002201817700002801839700002401867700002101891700001901912700003201931700001701963700002801980700002402008700001602032700002202048700001902070700001902089700002002108700001902128700002102147700002002168700002302188700001902211700002002230700001402250700002302264700001902287700002502306700002102331700002102352700002402373700002902397700002502426700002502451700002302476700002502499700002502524700002102549700002402570700002202594700003202616700002002648700002202668700001902690700002302709700002202732700002902754700002502783700002302808700001902831700001702850700002102867700001902888700002202907700002202929700002802951700002602979700002103005700001803026700002403044700002503068700002103093856003603114 2017 eng d a1613-413300aGenome-Wide Interactions with Dairy Intake for Body Mass Index in Adults of European Descent.0 aGenomeWide Interactions with Dairy Intake for Body Mass Index in c2017 Sep 213 aSCOPE: Body weight responds variably to the intake of dairy foods. Genetic variation may contribute to inter-individual variability in associations between body weight and dairy consumption.
METHODS AND RESULTS: A genome-wide interaction study to discover genetic variants that account for variation in BMI in the context of low-fat, high-fat and total dairy intake in cross-sectional analysis was conducted. Data from nine discovery studies (up to 25 513 European descent individuals) were meta-analyzed. Twenty-six genetic variants reached the selected significance threshold (p-interaction <10-7) , and six independent variants (LINC01512-rs7751666, PALM2/AKAP2-rs914359, ACTA2-rs1388, PPP1R12A-rs7961195, LINC00333-rs9635058, AC098847.1-rs1791355) were evaluated meta-analytically for replication of interaction in up to 17 675 individuals. Variant rs9635058 (128 kb 3' of LINC00333) was replicated (p-interaction = 0.004). In the discovery cohorts, rs9635058 interacted with dairy (p-interaction = 7.36 × 10-8) such that each serving of low-fat dairy was associated with 0.225 kg m-2 lower BMI per each additional copy of the effect allele (A). A second genetic variant (ACTA2-rs1388) approached interaction replication significance for low-fat dairy exposure.
CONCLUSION: Body weight responses to dairy intake may be modified by genotype, in that greater dairy intake may protect a genetic subgroup from higher body weight.
1 aSmith, Caren, E1 aFollis, Jack, L1 aDashti, Hassan, S1 aTanaka, Toshiko1 aGraff, Mariaelisa1 aFretts, Amanda, M1 aKilpeläinen, Tuomas, O1 aWojczynski, Mary, K1 aRichardson, Kris1 aNalls, Mike, A1 aSchulz, Christina-Alexandra1 aLiu, Yongmei1 aFrazier-Wood, Alexis, C1 avan Eekelen, Esther1 aWang, Carol1 ade Vries, Paul, S1 aMikkilä, Vera1 aRohde, Rebecca1 aPsaty, Bruce, M1 aHansen, Torben1 aFeitosa, Mary, F1 aLai, Chao-Qiang1 aHouston, Denise, K1 aFerruci, Luigi1 aEricson, Ulrika1 aWang, Zhe1 ade Mutsert, Renée1 aOddy, Wendy, H1 ade Jonge, Ester, A L1 aSeppälä, Ilkka1 aJustice, Anne, E1 aLemaitre, Rozenn, N1 aSørensen, Thorkild, I A1 aProvince, Michael, A1 aParnell, Laurence, D1 aGarcia, Melissa, E1 aBandinelli, Stefania1 aOrho-Melander, Marju1 aRich, Stephen, S1 aRosendaal, Frits, R1 aPennell, Craig, E1 ade Jong, Jessica, C Kiefte-1 aKähönen, Mika1 aYoung, Kristin, L1 aPedersen, Oluf1 aAslibekyan, Stella1 aRotter, Jerome, I1 aMook-Kanamori, Dennis, O1 aZillikens, Carola, M1 aRaitakari, Olli, T1 aNorth, Kari, E1 aOvervad, Kim1 aArnett, Donna, K1 aHofman, Albert1 aLehtimäki, Terho1 aTjønneland, Anne1 aUitterlinden, André, G1 aRivadeneira, Fernando1 aFranco, Oscar, H1 aGerman, Bruce1 aSiscovick, David, S1 aCupples, Adrienne, L1 aOrdovas, Jose, M uhttps://chs-nhlbi.org/node/7588