02680nas a2200289 4500008004100000022001400041245011600055210006900171260001600240300001500256520179300271100002202064700002202086700002202108700002702130700002102157700002202178700001802200700002002218700001802238700002002256700001802276700002302294700002002317700001702337856003602354 2016 eng d a1945-719700aInsulinlike growth factor binding protein-1 and ghrelin predict health outcomes among older adults: CHS cohort.0 aInsulinlike growth factor binding protein1 and ghrelin predict h c2016 Nov 07 ajc201627793 a

CONTEXT: Multiple diseases may explain the association of the growth hormone / insulinlike growth factor-I (GH/IGF-I) axis with longevity.

OBJECTIVE: To relate circulating GH/IGF-I system protein levels with major health events.

DESIGN: Cohort study Setting: Four US communities Participants: Adults (n=2268) 65 years and older free of diabetes and cardiovascular disease.

MEASUREMENTS: We assessed insulinlike growth factor binding protein-1 (IGFBP-1) and ghrelin in fasting and 2-hour oral glucose tolerance test (OGTT) blood samples, as well as fasting IGF-I and IGFBP-3. Hazard ratios for mortality and a composite outcome for first incident myocardial infarction, stroke, heart failure, hip fracture, or death were adjusted for sociodemographic, behavioral, and physiologic covariates.

RESULTS: During 13,930 person-years of follow-up, 48.1% individuals sustained one or more components of the composite outcome and 31.8% died. Versus the lowest quartiles, the highest quartiles of fasting and 2-h ghrelin were associated with a 27% higher (95% CI: 6%, 53%) and 39% higher (95% CI: 14%, 71%) risks of the composite outcome, respectively. The highest quartile of 2-h IGFBP-1 was associated with 35% higher (95% CI: 1%, 52%) risk of the composite endpoint. Similarly, higher mortality was significantly associated with higher fasting and 2-h ghrelin level, and with 2-h IGFBP-1 level. When examined together, 2-h post-OGTT levels of IGFBP-1 and ghrelin tended to predict outcomes better than fasting levels.

CONCLUSIONS: Circulating IGFBP-1 and ghrelin measured during an OGTT predict major health events and death in older adults, which may explain the influence of the GH-IGF-axis on lifespan and health.

1 aKaplan, Robert, C1 aStrizich, Garrett1 aAneke-Nash, Chino1 aDominguez-Islas, Clara1 aBůzková, Petra1 aStrickler, Howard1 aRohan, Thomas1 aPollak, Michael1 aKuller, Lewis1 aKizer, Jorge, R1 aCappola, Anne1 aLi, Christopher, I1 aPsaty, Bruce, M1 aNewman, Anne uhttps://chs-nhlbi.org/node/7258