01770nas a2200289 4500008004100000022001400041245015600055210006900211260001900280300001200299490000700311520085300318100002401171700002301195700002001218700002101238700002301259700001901282700002001301700001801321700002201339700002001361700002401381700001801405700002101423856003601444 2017 eng d a1366-580400aSleep-disordered breathing is associated with higher carboxymethyllysine level in elderly women but not elderly men in the cardiovascular health study.0 aSleepdisordered breathing is associated with higher carboxymethy c2017 May - Jun a361-3660 v223 a

CONTEXT: Carboxymethyl-lysine (CML) results from oxidative stress and has been linked to cardiovascular disease.

OBJECTIVE: The objective of this study is to investigate the association between sleep-disordered breathing (SDB) - a source of oxidative stress - and CML.

MATERIALS AND METHODS: About 1002 participants in the Cardiovascular Health Study (CHS) were studied.

RESULTS: Women with SDB had significantly higher CML concentration compared with those without SDB (OR = 1.63, 95%CI = 1.03-2.58, p = 0.04). The association was not significant among men.

DISCUSSION: SDB was associated with CML concentration among elderly women but not men in the Cardiovascular Health Study.

CONCLUSION: Accumulation of CML may be an adverse health consequence of SDB.

1 aAhiawodzi, Peter, D1 aKerber, Richard, A1 aTaylor, Kira, C1 aGroves, Frank, D1 aO'Brien, Elizabeth1 aIx, Joachim, H1 aKizer, Jorge, R1 aDjoussé, Luc1 aTracy, Russell, P1 aNewman, Anne, B1 aSiscovick, David, S1 aRobbins, John1 aMukamal, Kenneth uhttps://chs-nhlbi.org/node/733602520nas a2200181 4500008004100000022001400041245010500055210006900160260001600229520193100245100002402176700002102200700001802221700001902239700002002258700002402278856003602302 2020 eng d a1758-535X00aNon-Esterified Fatty Acids and Hospitalizations among Older Adults: The Cardiovascular Health Study.0 aNonEsterified Fatty Acids and Hospitalizations among Older Adult c2020 Sep 103 a

BACKGROUND: We sought to determine associations between total serum concentrations of non-esterified fatty acids (NEFAs) and incident total and cause-specific hospitalizations in a community-living cohort of elders.

METHODS: We included 4715 participants in the Cardiovascular Health Study who had fasting total serum NEFA measured at the 1992/93 clinic visit and were followed for a median of 12 years. We identified all inpatient admissions requiring at least an overnight hospitalization and used primary diagnostic codes to categorize cause-specific hospitalizations. We used Cox proportional hazards regression models to determine associations with time-to-first hospitalization and Poisson regression for the rate ratios (RR) of hospitalizations and days hospitalized.

RESULTS: We identified 21339 hospitalizations during follow-up. In fully adjusted models, higher total NEFAs were significantly associated with higher risk of incident hospitalization (Hazard Ratio (HR) per SD [0.2 mEq/L]=1.07, 95%CI=1.03-1.10, P&0.001), number of hospitalizations (RR per SD=1.04, 95%CI=1.01-1.07, P=0.01), and total number of days hospitalized (RR per SD=1.06, 95%CI=1.01-1.10, P=0.01). Among hospitalization subtypes, higher NEFA was associated with higher likelihood of mental, neurologic, respiratory, and musculoskeletal causes of hospitalization. Among specific causes of hospitalization, higher NEFA was associated with diabetes, pneumonia, and gastrointestinal hemorrhage.

CONCLUSIONS: Higher fasting total serum NEFAs are associated with a broad array of causes of hospitalization among older adults. While some of these were expected, our results illustrate a possible utility of NEFAs as biomarkers for risk of hospitalization, and total days hospitalized, in older adults. Further research is needed to determine whether interventions based on NEFAs might be feasible.

1 aAhiawodzi, Peter, D1 aBůzková, Petra1 aDjoussé, Luc1 aIx, Joachim, H1 aKizer, Jorge, R1 aMukamal, Kenneth, J uhttps://chs-nhlbi.org/node/8476