01955nas a2200217   4500008004100000022001400041245014500055210006900200260001300269300001200282490000800294520125300302100002201555700002101577700002001598700002101618700002001639700002101659700002101680856003601701       2017                        eng d  a1432-082700aAssociation of Plasma SDF-1 with Bone Mineral Density, Body Composition, and Hip Fractures in Older Adults: The Cardiovascular Health Study.0 aAssociation of Plasma SDF1 with Bone Mineral Density Body Compos  c2017 Jun  a599-6080 v1003 a<p>Aging is associated with an increase in circulating inflammatory factors. One, the cytokine stromal cell-derived factor 1 (SDF-1 or CXCL12), is critical to stem cell mobilization, migration, and homing as well as to bone marrow stem cell (BMSC), osteoblast, and osteoclast function. SDF-1 has pleiotropic roles in bone formation and BMSC differentiation into osteoblasts/osteocytes, and in osteoprogenitor cell survival. The objective of this study was to examine the association of plasma SDF-1 in participants in the cardiovascular health study (CHS) with bone mineral density (BMD), body composition, and incident hip fractures. In 1536 CHS participants, SDF-1 plasma levels were significantly associated with increasing age (p < 0.01) and male gender (p = 0.04), but not with race (p = 0.63). In multivariable-adjusted models, higher SDF-1 levels were associated with lower total hip BMD (p = 0.02). However, there was no significant association of SDF-1 with hip fractures (p = 0.53). In summary, circulating plasma levels of SDF-1 are associated with increasing age and independently associated with lower total hip BMD in both men and women. These findings suggest that SDF-1 levels are linked to bone homeostasis.</p>1 aCarbone, Laura, D1 aBůzková, Petra1 aFink, Howard, A1 aRobbins, John, A1 aBethel, Monique1 aHamrick, Mark, W1 aHill, William, D  uhttps://chs-nhlbi.org/node/7341