02627nas a2200277 4500008004100000022001400041245009500055210006900150260001600219520176300235100002201998700001702020700002702037700002102064700002202085700001802107700002502125700002102150700002502171700002102196700002002217700002702237700002502264700002402289856003602313 2017 eng d a1546-415600aCoronary Artery Bypass Graft Surgery and Dementia Risk in the Cardiovascular Health Study.0 aCoronary Artery Bypass Graft Surgery and Dementia Risk in the Ca c2017 Mar 033 a

INTRODUCTION: The association between history of coronary artery bypass graft surgery (CABG) and dementia risk remains unclear.

METHODS: We conducted a prospective cohort analysis using data on 3155 elderly adults free from prevalent dementia from the US population-based Cardiovascular Health Study (CHS) with adjudicated incident all-cause dementia, Alzheimer disease (AD), vascular dementia (VaD), and mixed dementia.

RESULTS: In the CHS, the hazard ratio (HR) for all-cause dementia was 1.93 [95% confidence interval (CI), 1.36-2.74] for those with CABG history compared with those with no CABG history after adjustment for potential confounders. Similar HRs were observed for AD (HR=1.71; 95% CI, 0.98-2.98), VaD (HR=1.42; 95% CI, 0.56-3.65), and mixed dementia (HR=2.73; 95% CI, 1.55-4.80). The same pattern of results was observed when these CHS findings were pooled with a prior prospective study, the pooled HRs were 1.96 (95% CI, 1.42-2.69) for all-cause dementia, 1.71 (95% CI, 1.04-2.79) for AD and 2.20 (95% CI, 0.78-6.19) for VaD.

DISCUSSION: Our results suggest CABG history is associated with long-term dementia risk. Further investigation is warranted to examine the causal mechanisms which may explain this relationship or whether the association reflects differences in coronary artery disease severity.This is an open-access article distributed under the terms of the Creative Commons Attribution-Non Commercial-No Derivatives License 4.0 (CCBY-NC-ND), where it is permissible to download and share the work provided it is properly cited. The work cannot be changed in any way or used commercially without permission from the journal. http://creativecommons.org/licenses/by-nc-nd/4.0/.

1 aKuźma, Elżbieta1 aAirdrie, Jac1 aLittlejohns, Thomas, J1 aLourida, Ilianna1 aThompson-Coon, Jo1 aLang, Iain, A1 aScrobotovici, Monica1 aThacker, Evan, L1 aFitzpatrick, Annette1 aKuller, Lewis, H1 aLopez, Oscar, L1 aLongstreth, William, T1 aUkoumunne, Obioha, C1 aLlewellyn, David, J uhttps://chs-nhlbi.org/node/7348