03799nas a2200757 4500008004100000022001400041245019200055210006900247260001300316300001200329490000700341520158600348653002301934653002101957653004101978653001902019653000902038653002602047653002602073653002502099653002702124653001602151653002502167653001102192653001102203653000902214653001602223653003602239100002002275700002002295700002702315700001902342700001802361700001302379700002002392700002302412700001502435700001902450700002002469700002002489700002502509700002502534700001902559700002202578700002102600700001802621700002002639700001802659700002202677700002102699700002502720700002202745700001702767700002302784700002002807700002102827700001902848700001202867700001302879700001902892700002502911700002402936700002102960700002402981856003603005 2015 eng d a1613-413300aDietary fatty acids modulate associations between genetic variants and circulating fatty acids in plasma and erythrocyte membranes: Meta-analysis of nine studies in the CHARGE consortium.0 aDietary fatty acids modulate associations between genetic varian c2015 Jul a1373-830 v593 a
SCOPE: Tissue concentrations of omega-3 fatty acids may reduce cardiovascular disease risk, and genetic variants are associated with circulating fatty acids concentrations. Whether dietary fatty acids interact with genetic variants to modify circulating omega-3 fatty acids is unclear. We evaluated interactions between genetic variants and fatty acid intakes for circulating alpha-linoleic acid, eicosapentaenoic acid, docosahexaenoic acid, and docosapentaenoic acid.
METHODS AND RESULTS: We conducted meta-analyses (N = 11 668) evaluating interactions between dietary fatty acids and genetic variants (rs174538 and rs174548 in FADS1 (fatty acid desaturase 1), rs7435 in AGPAT3 (1-acyl-sn-glycerol-3-phosphate), rs4985167 in PDXDC1 (pyridoxal-dependent decarboxylase domain-containing 1), rs780094 in GCKR (glucokinase regulatory protein), and rs3734398 in ELOVL2 (fatty acid elongase 2)). Stratification by measurement compartment (plasma versus erthyrocyte) revealed compartment-specific interactions between FADS1 rs174538 and rs174548 and dietary alpha-linolenic acid and linoleic acid for docosahexaenoic acid and docosapentaenoic acid.
CONCLUSION: Our findings reinforce earlier reports that genetically based differences in circulating fatty acids may be partially due to differences in the conversion of fatty acid precursors. Further, fatty acids measurement compartment may modify gene-diet relationships, and considering compartment may improve the detection of gene-fatty acids interactions for circulating fatty acid outcomes.
10aAcetyltransferases10aAcyltransferases10aAdaptor Proteins, Signal Transducing10aCarboxy-Lyases10aDiet10aDocosahexaenoic Acids10aEicosapentaenoic Acid10aErythrocyte Membrane10aFatty Acid Desaturases10aFatty Acids10aFatty Acids, Omega-310aFemale10aHumans10aMale10aMiddle Aged10aPolymorphism, Single Nucleotide1 aSmith, Caren, E1 aFollis, Jack, L1 aNettleton, Jennifer, A1 aFoy, Millennia1 aH Y Wu, Jason1 aMa, Yiyi1 aTanaka, Toshiko1 aManichakul, Ani, W1 aWu, Hongyu1 aChu, Audrey, Y1 aSteffen, Lyn, M1 aFornage, Myriam1 aMozaffarian, Dariush1 aKabagambe, Edmond, K1 aFerruci, Luigi1 aChen, Yii-Der Ida1 aRich, Stephen, S1 aDjoussé, Luc1 aRidker, Paul, M1 aTang, Weihong1 aMcKnight, Barbara1 aTsai, Michael, Y1 aBandinelli, Stefania1 aRotter, Jerome, I1 aHu, Frank, B1 aChasman, Daniel, I1 aPsaty, Bruce, M1 aArnett, Donna, K1 aKing, Irena, B1 aSun, Qi1 aWang, Lu1 aLumley, Thomas1 aChiuve, Stephanie, E1 aSiscovick, David, S1 aOrdovas, Jose, M1 aLemaitre, Rozenn, N uhttps://chs-nhlbi.org/node/6687