TY - JOUR T1 - Clinical correlates of ventricular and sulcal size on cranial magnetic resonance imaging of 3,301 elderly people. The Cardiovascular Health Study. Collaborative Research Group. JF - Neuroepidemiology Y1 - 2000 A1 - Longstreth, W T A1 - Arnold, A M A1 - Manolio, T A A1 - Burke, G L A1 - Bryan, N A1 - Jungreis, C A A1 - O'Leary, D A1 - Enright, P L A1 - Fried, L KW - Age Distribution KW - Age Factors KW - Aged KW - Aging KW - Cerebral Ventricles KW - Continental Population Groups KW - Cross-Sectional Studies KW - Diabetes Complications KW - Female KW - Humans KW - Hypertrophy KW - Linear Models KW - Magnetic Resonance Imaging KW - Male KW - Multivariate Analysis KW - Risk Factors KW - Severity of Illness Index KW - Sex Distribution KW - Sex Factors KW - Smoking KW - Stroke AB -

To identify potential risk factors for and clinical manifestations of ventricular and sulcal enlargement on cranial magnetic resonance imaging (MRI), 3,301 community-dwelling people 65 years or older without a history of stroke or transient ischemic attack underwent extensive standardized evaluations and MRI. In the multivariate model, increased age and white matter grade on MRI were the dominant risk factors for ventricular and sulcal grade. For ventricular grade, other than race, for which non-Blacks had higher grades, models for men and women shared no other factors. For sulcal grades, models for men and women shared variables reflecting cigarette smoking and diabetes. Clinical features were correlated more strongly with ventricular than sulcal grade and more strongly for women than men. Significant age-adjusted correlations between ventricular grade and the Digit-Symbol Substitution Test were found for men and women. Prospective studies will be needed to extend findings of this cross-sectional analysis.

VL - 19 IS - 1 U1 - https://www.ncbi.nlm.nih.gov/pubmed/10654286?dopt=Abstract ER -