TY - JOUR T1 - Chlamydia pneumoniae, herpes simplex virus type 1, and cytomegalovirus and incident myocardial infarction and coronary heart disease death in older adults : the Cardiovascular Health Study. JF - Circulation Y1 - 2000 A1 - Siscovick, D S A1 - Schwartz, S M A1 - Corey, L A1 - Grayston, J T A1 - Ashley, R A1 - Wang, S P A1 - Psaty, B M A1 - Tracy, R P A1 - Kuller, L H A1 - Kronmal, R A KW - Adult KW - Age Factors KW - Aged KW - Antibodies, Bacterial KW - Antibodies, Viral KW - Case-Control Studies KW - Chlamydophila pneumoniae KW - Coronary Disease KW - Cytomegalovirus KW - Female KW - Herpesvirus 1, Human KW - HIV Antibodies KW - Humans KW - Immunoglobulin G KW - Male KW - Myocardial Infarction KW - Risk Factors AB -

BACKGROUND: Whether serological evidence of prior infection with Chlamydia pneumoniae, herpes simplex virus type 1 (HSV-1), and cytomegalovirus (CMV) is associated with myocardial infarction (MI) and coronary heart disease (CHD) death remains a source of controversy.

METHODS AND RESULTS: We conducted a nested case-control study among participants in the Cardiovascular Health Study, a cohort study of persons aged >/=65 years. Cases experienced an incident MI and CHD death (n=213). Control subjects were matched to cases by age, sex, clinic, year of enrollment, and month of blood draw (n=405). Serum was analyzed for IgG antibodies to C pneumoniae, HSV-1, and CMV. After adjustment for other risk factors, the risk of MI and CHD death was associated with the presence of IgG antibodies to HSV-1 (odds ratio [OR] 2.0, 95% CI 1.1 to 3.6) but was not associated with the presence of IgG antibodies to either C pneumoniae (OR 1.1, 95% CI 0.7 to 1.8) or CMV (OR 1.2, 95% CI 0.7 to 1.9). Although there was little association with low to moderate C pneumoniae antibody titers (

CONCLUSIONS: Among older adults, the presence of IgG antibodies to HSV-1 was associated with a 2-fold increase in the risk of incident MI and CHD death. For C pneumoniae, only high-titer IgG antibodies were associated with an increased risk of MI and CHD death. The presence of IgG antibodies to CMV was not associated with risk among the elderly.

VL - 102 IS - 19 U1 - https://www.ncbi.nlm.nih.gov/pubmed/11067785?dopt=Abstract ER -