TY - JOUR T1 - Sleep-disordered breathing and cardiovascular disease: cross-sectional results of the Sleep Heart Health Study. JF - Am J Respir Crit Care Med Y1 - 2001 A1 - Shahar, E A1 - Whitney, C W A1 - Redline, S A1 - Lee, E T A1 - Newman, A B A1 - Nieto, F J A1 - O'Connor, G T A1 - Boland, L L A1 - Schwartz, J E A1 - Samet, J M KW - Aged KW - Cardiovascular Diseases KW - Cohort Studies KW - Cross-Sectional Studies KW - Female KW - Humans KW - Male KW - Middle Aged KW - Sleep Apnea Syndromes AB -

Disordered breathing during sleep is associated with acute, unfavorable effects on cardiovascular physiology, but few studies have examined its postulated association with cardiovascular disease (CVD). We examined the cross-sectional association between sleep- disordered breathing and self-reported CVD in 6,424 free-living individuals who underwent overnight, unattended polysomnography at home. Sleep-disordered breathing was quantified by the apnea-hypopnea index (AHI)-the average number of apneas and hypopneas per hour of sleep. Mild to moderate disordered breathing during sleep was highly prevalent in the sample (median AHI: 4.4; interquartile range: 1.3 to 11.0). A total of 1,023 participants (16%) reported at least one manifestation of CVD (myocardial infarction, angina, coronary revascularization procedure, heart failure, or stroke). The multivariable-adjusted relative odds (95% CI) of prevalent CVD for the second, third, and fourth quartiles of the AHI (versus the first) were 0.98 (0.77-1.24), 1.28 (1.02-1.61), and 1.42 (1.13-1.78), respectively. Sleep-disordered breathing was associated more strongly with self-reported heart failure and stroke than with self-reported coronary heart disease: the relative odds (95% CI) of heart failure, stroke, and coronary heart disease (upper versus lower AHI quartile) were 2.38 (1.22-4.62), 1.58 (1.02- 2.46), and 1.27 (0.99-1.62), respectively. These findings are compatible with modest to moderate effects of sleep-disordered breathing on heterogeneous manifestations of CVD within a range of AHI values that are considered normal or only mildly elevated.

VL - 163 IS - 1 U1 - https://www.ncbi.nlm.nih.gov/pubmed/11208620?dopt=Abstract ER -