TY - JOUR T1 - Prospective study of the G20210A polymorphism in the prothrombin gene, plasma prothrombin concentration, and incidence of venous thromboembolism. JF - Am J Hematol Y1 - 2002 A1 - Folsom, Aaron R A1 - Cushman, Mary A1 - Tsai, Michael Y A1 - Heckbert, Susan R A1 - Aleksic, Nena KW - African Continental Ancestry Group KW - Age Factors KW - Aged KW - Case-Control Studies KW - European Continental Ancestry Group KW - Genotype KW - Humans KW - Incidence KW - Middle Aged KW - Odds Ratio KW - Polymorphism, Single Nucleotide KW - Prospective Studies KW - Prothrombin KW - Recurrence KW - Research Design KW - Risk Factors KW - Thromboembolism KW - United States AB -

Case-control studies have indicated increased risk of venous thrombosis associated with the prothrombin gene G20210A polymorphism and with elevated plasma prothrombin levels. We sought to confirm these results in a prospective population-based study of 21,690 persons. We measured G20210A and prothrombin antigen on pre-event blood samples of 302 participants who developed venous thromboembolism (VTE) and 626 participants who remained free of VTE. Approximately 4.0% of cases and 2.4% of controls carried the G20210A polymorphism, but only one of 137 African Americans did. The odds ratio in whites was 1.87 (95% CI = 0.85, 4.11)--higher for those who reported a prior history of VTE (OR = 5.44) than those reporting no VTE history (OR = 1.41) and in those with idiopathic VTE (OR = 2.51) than those with secondary VTE (OR = 1.38). There was no association between venous thromboembolism and plasma prothrombin antigen level. We estimated that the G20210A polymorphism may account for approximately 2.5% of venous thromboembolism events in United States whites.

VL - 71 IS - 4 U1 - https://www.ncbi.nlm.nih.gov/pubmed/12447958?dopt=Abstract ER -