TY - JOUR
T1 - Genome-wide meta-analysis associates HLA-DQA1/DRB1 and LPA and lifestyle factors with human longevity.
JF - Nat Commun
Y1 - 2017
A1 - Joshi, Peter K
A1 - Pirastu, Nicola
A1 - Kentistou, Katherine A
A1 - Fischer, Krista
A1 - Hofer, Edith
A1 - Schraut, Katharina E
A1 - Clark, David W
A1 - Nutile, Teresa
A1 - Barnes, Catriona L K
A1 - Timmers, Paul R H J
A1 - Shen, Xia
A1 - Gandin, Ilaria
A1 - McDaid, Aaron F
A1 - Hansen, Thomas Folkmann
A1 - Gordon, Scott D
A1 - Giulianini, Franco
A1 - Boutin, Thibaud S
A1 - Abdellaoui, Abdel
A1 - Zhao, Wei
A1 - Medina-Gómez, Carolina
A1 - Bartz, Traci M
A1 - Trompet, Stella
A1 - Lange, Leslie A
A1 - Raffield, Laura
A1 - van der Spek, Ashley
A1 - Galesloot, Tessel E
A1 - Proitsi, Petroula
A1 - Yanek, Lisa R
A1 - Bielak, Lawrence F
A1 - Payton, Antony
A1 - Murgia, Federico
A1 - Concas, Maria Pina
A1 - Biino, Ginevra
A1 - Tajuddin, Salman M
A1 - Seppälä, Ilkka
A1 - Amin, Najaf
A1 - Boerwinkle, Eric
A1 - Børglum, Anders D
A1 - Campbell, Archie
A1 - Demerath, Ellen W
A1 - Demuth, Ilja
A1 - Faul, Jessica D
A1 - Ford, Ian
A1 - Gialluisi, Alessandro
A1 - Gögele, Martin
A1 - Graff, Mariaelisa
A1 - Hingorani, Aroon
A1 - Hottenga, Jouke-Jan
A1 - Hougaard, David M
A1 - Hurme, Mikko A
A1 - Ikram, M Arfan
A1 - Jylhä, Marja
A1 - Kuh, Diana
A1 - Ligthart, Lannie
A1 - Lill, Christina M
A1 - Lindenberger, Ulman
A1 - Lumley, Thomas
A1 - Mägi, Reedik
A1 - Marques-Vidal, Pedro
A1 - Medland, Sarah E
A1 - Milani, Lili
A1 - Nagy, Reka
A1 - Ollier, William E R
A1 - Peyser, Patricia A
A1 - Pramstaller, Peter P
A1 - Ridker, Paul M
A1 - Rivadeneira, Fernando
A1 - Ruggiero, Daniela
A1 - Saba, Yasaman
A1 - Schmidt, Reinhold
A1 - Schmidt, Helena
A1 - Slagboom, P Eline
A1 - Smith, Blair H
A1 - Smith, Jennifer A
A1 - Sotoodehnia, Nona
A1 - Steinhagen-Thiessen, Elisabeth
A1 - van Rooij, Frank J A
A1 - Verbeek, André L
A1 - Vermeulen, Sita H
A1 - Vollenweider, Peter
A1 - Wang, Yunpeng
A1 - Werge, Thomas
A1 - Whitfield, John B
A1 - Zonderman, Alan B
A1 - Lehtimäki, Terho
A1 - Evans, Michele K
A1 - Pirastu, Mario
A1 - Fuchsberger, Christian
A1 - Bertram, Lars
A1 - Pendleton, Neil
A1 - Kardia, Sharon L R
A1 - Ciullo, Marina
A1 - Becker, Diane M
A1 - Wong, Andrew
A1 - Psaty, Bruce M
A1 - van Duijn, Cornelia M
A1 - Wilson, James G
A1 - Jukema, J Wouter
A1 - Kiemeney, Lambertus
A1 - Uitterlinden, André G
A1 - Franceschini, Nora
A1 - North, Kari E
A1 - Weir, David R
A1 - Metspalu, Andres
A1 - Boomsma, Dorret I
A1 - Hayward, Caroline
A1 - Chasman, Daniel
A1 - Martin, Nicholas G
A1 - Sattar, Naveed
A1 - Campbell, Harry
A1 - Esko, Tõnu
A1 - Kutalik, Zoltán
A1 - Wilson, James F
AB - Genomic analysis of longevity offers the potential to illuminate the biology of human aging. Here, using genome-wide association meta-analysis of 606,059 parents' survival, we discover two regions associated with longevity (HLA-DQA1/DRB1 and LPA). We also validate previous suggestions that APOE, CHRNA3/5, CDKN2A/B, SH2B3 and FOXO3A influence longevity. Next we show that giving up smoking, educational attainment, openness to new experience and high-density lipoprotein (HDL) cholesterol levels are most positively genetically correlated with lifespan while susceptibility to coronary artery disease (CAD), cigarettes smoked per day, lung cancer, insulin resistance and body fat are most negatively correlated. We suggest that the effect of education on lifespan is principally mediated through smoking while the effect of obesity appears to act via CAD. Using instrumental variables, we suggest that an increase of one body mass index unit reduces lifespan by 7 months while 1 year of education adds 11 months to expected lifespan.Variability in human longevity is genetically influenced. Using genetic data of parental lifespan, the authors identify associations at HLA-DQA/DRB1 and LPA and find that genetic variants that increase educational attainment have a positive effect on lifespan whereas increasing BMI negatively affects lifespan.

VL - 8
IS - 1
ER -