TY - JOUR
T1 - Telomeres and the natural lifespan limit in humans.
JF - Aging (Albany NY)
Y1 - 2017
A1 - Steenstrup, Troels
A1 - Kark, Jeremy D
A1 - Verhulst, Simon
A1 - Thinggaard, Mikael
A1 - Hjelmborg, Jacob V B
A1 - DalgĂ„rd, Christine
A1 - Kyvik, Kirsten Ohm
A1 - Christiansen, Lene
A1 - Mangino, Massimo
A1 - Spector, Timothy D
A1 - Petersen, Inge
A1 - Kimura, Masayuki
A1 - Benetos, Athanase
A1 - Labat, Carlos
A1 - Sinnreich, Ronit
A1 - Hwang, Shih-Jen
A1 - Levy, Daniel
A1 - Hunt, Steven C
A1 - Fitzpatrick, Annette L
A1 - Chen, Wei
A1 - Berenson, Gerald S
A1 - Barbieri, Michelangela
A1 - Paolisso, Giuseppe
A1 - Gadalla, Shahinaz M
A1 - Savage, Sharon A
A1 - Christensen, Kaare
A1 - Yashin, Anatoliy I
A1 - Arbeev, Konstantin G
A1 - Aviv, Abraham
AB - An ongoing debate in demography has focused on whether the human lifespan has a maximal natural limit. Taking a mechanistic perspective, and knowing that short telomeres are associated with diminished longevity, we examined whether telomere length dynamics during adult life could set a maximal natural lifespan limit. We define leukocyte telomere length of 5 kb as the 'telomeric brink', which denotes a high risk of imminent death. We show that a subset of adults may reach the telomeric brink within the current life expectancy and more so for a 100-year life expectancy. Thus, secular trends in life expectancy should confront a biological limit due to crossing the telomeric brink.

VL - 9
IS - 4
ER -