TY - JOUR
T1 - Multi-Ancestry Genome-Wide Association Study of Lipid Levels Incorporating Gene-Alcohol Interactions.
JF - Am J Epidemiol
Y1 - 2019
A1 - de Vries, Paul S
A1 - Brown, Michael R
A1 - Bentley, Amy R
A1 - Sung, Yun J
A1 - Winkler, Thomas W
A1 - Ntalla, Ioanna
A1 - Schwander, Karen
A1 - Kraja, Aldi T
A1 - Guo, Xiuqing
A1 - Franceschini, Nora
A1 - Cheng, Ching-Yu
A1 - Sim, Xueling
A1 - Vojinovic, Dina
A1 - Huffman, Jennifer E
A1 - Musani, Solomon K
A1 - Li, Changwei
A1 - Feitosa, Mary F
A1 - Richard, Melissa A
A1 - Noordam, Raymond
A1 - Aschard, Hugues
A1 - Bartz, Traci M
A1 - Bielak, Lawrence F
A1 - Deng, Xuan
A1 - Dorajoo, Rajkumar
A1 - Lohman, Kurt K
A1 - Manning, Alisa K
A1 - Rankinen, Tuomo
A1 - Smith, Albert V
A1 - Tajuddin, Salman M
A1 - Evangelou, Evangelos
A1 - Graff, Mariaelisa
A1 - Alver, Maris
A1 - Boissel, Mathilde
A1 - Chai, Jin Fang
A1 - Chen, Xu
A1 - Divers, Jasmin
A1 - Gandin, Ilaria
A1 - Gao, Chuan
A1 - Goel, Anuj
A1 - Hagemeijer, Yanick
A1 - Harris, Sarah E
A1 - Hartwig, Fernando P
A1 - He, Meian
A1 - Horimoto, Andrea R V R
A1 - Hsu, Fang-Chi
A1 - Jackson, Anne U
A1 - Kasturiratne, Anuradhani
A1 - Komulainen, Pirjo
A1 - Kuhnel, Brigitte
A1 - Laguzzi, Federica
A1 - Lee, Joseph H
A1 - Luan, Jian'an
A1 - Lyytikäinen, Leo-Pekka
A1 - Matoba, Nana
A1 - Nolte, Ilja M
A1 - Pietzner, Maik
A1 - Riaz, Muhammad
A1 - Said, M Abdullah
A1 - Scott, Robert A
A1 - Sofer, Tamar
A1 - Stančáková, Alena
A1 - Takeuchi, Fumihiko
A1 - Tayo, Bamidele O
A1 - van der Most, Peter J
A1 - Varga, Tibor V
A1 - Wang, Yajuan
A1 - Ware, Erin B
A1 - Wen, Wanqing
A1 - Yanek, Lisa R
A1 - Zhang, Weihua
A1 - Zhao, Jing Hua
A1 - Afaq, Saima
A1 - Amin, Najaf
A1 - Amini, Marzyeh
A1 - Arking, Dan E
A1 - Aung, Tin
A1 - Ballantyne, Christie
A1 - Boerwinkle, Eric
A1 - Broeckel, Ulrich
A1 - Campbell, Archie
A1 - Canouil, Mickaël
A1 - Charumathi, Sabanayagam
A1 - Chen, Yii-Der Ida
A1 - Connell, John M
A1 - de Faire, Ulf
A1 - de Las Fuentes, Lisa
A1 - de Mutsert, Renée
A1 - de Silva, H Janaka
A1 - Ding, Jingzhong
A1 - Dominiczak, Anna F
A1 - Duan, Qing
A1 - Eaton, Charles B
A1 - Eppinga, Ruben N
A1 - Faul, Jessica D
A1 - Fisher, Virginia
A1 - Forrester, Terrence
A1 - Franco, Oscar H
A1 - Friedlander, Yechiel
A1 - Ghanbari, Mohsen
A1 - Giulianini, Franco
A1 - Grabe, Hans J
A1 - Grove, Megan L
A1 - Gu, C Charles
A1 - Harris, Tamara B
A1 - Heikkinen, Sami
A1 - Heng, Chew-Kiat
A1 - Hirata, Makoto
A1 - Hixson, James E
A1 - Howard, Barbara V
A1 - Ikram, M Arfan
A1 - Jacobs, David R
A1 - Johnson, Craig
A1 - Jonas, Jost Bruno
A1 - Kammerer, Candace M
A1 - Katsuya, Tomohiro
A1 - Khor, Chiea Chuen
A1 - Kilpeläinen, Tuomas O
A1 - Koh, Woon-Puay
A1 - Koistinen, Heikki A
A1 - Kolcic, Ivana
A1 - Kooperberg, Charles
A1 - Krieger, Jose E
A1 - Kritchevsky, Steve B
A1 - Kubo, Michiaki
A1 - Kuusisto, Johanna
A1 - Lakka, Timo A
A1 - Langefeld, Carl D
A1 - Langenberg, Claudia
A1 - Launer, Lenore J
A1 - Lehne, Benjamin
A1 - Lemaitre, Rozenn N
A1 - Li, Yize
A1 - Liang, Jingjing
A1 - Liu, Jianjun
A1 - Liu, Kiang
A1 - Loh, Marie
A1 - Louie, Tin
A1 - Mägi, Reedik
A1 - Manichaikul, Ani W
A1 - McKenzie, Colin A
A1 - Meitinger, Thomas
A1 - Metspalu, Andres
A1 - Milaneschi, Yuri
A1 - Milani, Lili
A1 - Mohlke, Karen L
A1 - Mosley, Thomas H
A1 - Mukamal, Kenneth J
A1 - Nalls, Mike A
A1 - Nauck, Matthias
A1 - Nelson, Christopher P
A1 - Sotoodehnia, Nona
A1 - O'Connell, Jeff R
A1 - Palmer, Nicholette D
A1 - Pazoki, Raha
A1 - Pedersen, Nancy L
A1 - Peters, Annette
A1 - Peyser, Patricia A
A1 - Polasek, Ozren
A1 - Poulter, Neil
A1 - Raffel, Leslie J
A1 - Raitakari, Olli T
A1 - Reiner, Alex P
A1 - Rice, Treva K
A1 - Rich, Stephen S
A1 - Robino, Antonietta
A1 - Robinson, Jennifer G
A1 - Rose, Lynda M
A1 - Rudan, Igor
A1 - Schmidt, Carsten O
A1 - Schreiner, Pamela J
A1 - Scott, William R
A1 - Sever, Peter
A1 - Shi, Yuan
A1 - Sidney, Stephen
A1 - Sims, Mario
A1 - Smith, Blair H
A1 - Smith, Jennifer A
A1 - Snieder, Harold
A1 - Starr, John M
A1 - Strauch, Konstantin
A1 - Tan, Nicholas
A1 - Taylor, Kent D
A1 - Teo, Yik Ying
A1 - Tham, Yih Chung
A1 - Uitterlinden, André G
A1 - van Heemst, Diana
A1 - Vuckovic, Dragana
A1 - Waldenberger, Melanie
A1 - Wang, Lihua
A1 - Wang, Yujie
A1 - Wang, Zhe
A1 - Wei, Wen Bin
A1 - Williams, Christine
A1 - Wilson, Gregory
A1 - Wojczynski, Mary K
A1 - Yao, Jie
A1 - Yu, Bing
A1 - Yu, Caizheng
A1 - Yuan, Jian-Min
A1 - Zhao, Wei
A1 - Zonderman, Alan B
A1 - Becker, Diane M
A1 - Boehnke, Michael
A1 - Bowden, Donald W
A1 - Chambers, John C
A1 - Deary, Ian J
A1 - Esko, Tõnu
A1 - Farrall, Martin
A1 - Franks, Paul W
A1 - Freedman, Barry I
A1 - Froguel, Philippe
A1 - Gasparini, Paolo
A1 - Gieger, Christian
A1 - Horta, Bernardo L
A1 - Kamatani, Yoichiro
A1 - Kato, Norihiro
A1 - Kooner, Jaspal S
A1 - Laakso, Markku
A1 - Leander, Karin
A1 - Lehtimäki, Terho
A1 - Magnusson, Patrik K E
A1 - Penninx, Brenda
A1 - Pereira, Alexandre C
A1 - Rauramaa, Rainer
A1 - Samani, Nilesh J
A1 - Scott, James
A1 - Shu, Xiao-Ou
A1 - van der Harst, Pim
A1 - Wagenknecht, Lynne E
A1 - Wang, Ya Xing
A1 - Wareham, Nicholas J
A1 - Watkins, Hugh
A1 - Weir, David R
A1 - Wickremasinghe, Ananda R
A1 - Zheng, Wei
A1 - Elliott, Paul
A1 - North, Kari E
A1 - Bouchard, Claude
A1 - Evans, Michele K
A1 - Gudnason, Vilmundur
A1 - Liu, Ching-Ti
A1 - Liu, Yongmei
A1 - Psaty, Bruce M
A1 - Ridker, Paul M
A1 - van Dam, Rob M
A1 - Kardia, Sharon L R
A1 - Zhu, Xiaofeng
A1 - Rotimi, Charles N
A1 - Mook-Kanamori, Dennis O
A1 - Fornage, Myriam
A1 - Kelly, Tanika N
A1 - Fox, Ervin R
A1 - Hayward, Caroline
A1 - van Duijn, Cornelia M
A1 - Tai, E Shyong
A1 - Wong, Tien Yin
A1 - Liu, Jingmin
A1 - Rotter, Jerome I
A1 - Gauderman, W James
A1 - Province, Michael A
A1 - Munroe, Patricia B
A1 - Rice, Kenneth
A1 - Chasman, Daniel I
A1 - Cupples, L Adrienne
A1 - Rao, Dabeeru C
A1 - Morrison, Alanna C
AB - An individual's lipid profile is influenced by genetic variants and alcohol consumption, but the contribution of interactions between these exposures has not been studied. We therefore incorporated gene-alcohol interactions into a multi-ancestry genome-wide association study of levels of high-density lipoprotein cholesterol, low-density lipoprotein cholesterol, and triglycerides. We included 45 studies in Stage 1 (genome-wide discovery) and 66 studies in Stage 2 (focused follow-up), for a total of 394,584 individuals from five ancestry groups. Genetic main and interaction effects were jointly assessed by a 2 degrees of freedom (DF) test, and a 1 DF test was used to assess the interaction effects alone. Variants at 495 loci were at least suggestively associated (P < 1 × 10-6) with lipid levels in Stage 1 and were evaluated in Stage 2, followed by combined analyses of Stage 1 and Stage 2. In the combined analysis of Stage 1 and Stage 2, 147 independent loci were associated with lipid levels at P < 5 × 10-8 using 2 DF tests, of which 18 were novel. No genome-wide significant associations were found testing the interaction effect alone. The novel loci included several genes (PCSK5, VEGFB, and A1CF) with a putative role in lipid metabolism based on existing evidence from cellular and experimental models.

ER -