TY - JOUR
T1 - Gene-educational attainment interactions in a multi-ancestry genome-wide meta-analysis identify novel blood pressure loci.
JF - Mol Psychiatry
Y1 - 2020
A1 - de Las Fuentes, Lisa
A1 - Sung, Yun Ju
A1 - Noordam, Raymond
A1 - Winkler, Thomas
A1 - Feitosa, Mary F
A1 - Schwander, Karen
A1 - Bentley, Amy R
A1 - Brown, Michael R
A1 - Guo, Xiuqing
A1 - Manning, Alisa
A1 - Chasman, Daniel I
A1 - Aschard, Hugues
A1 - Bartz, Traci M
A1 - Bielak, Lawrence F
A1 - Campbell, Archie
A1 - Cheng, Ching-Yu
A1 - Dorajoo, Rajkumar
A1 - Hartwig, Fernando P
A1 - Horimoto, A R V R
A1 - Li, Changwei
A1 - Li-Gao, Ruifang
A1 - Liu, Yongmei
A1 - Marten, Jonathan
A1 - Musani, Solomon K
A1 - Ntalla, Ioanna
A1 - Rankinen, Tuomo
A1 - Richard, Melissa
A1 - Sim, Xueling
A1 - Smith, Albert V
A1 - Tajuddin, Salman M
A1 - Tayo, Bamidele O
A1 - Vojinovic, Dina
A1 - Warren, Helen R
A1 - Xuan, Deng
A1 - Alver, Maris
A1 - Boissel, Mathilde
A1 - Chai, Jin-Fang
A1 - Chen, Xu
A1 - Christensen, Kaare
A1 - Divers, Jasmin
A1 - Evangelou, Evangelos
A1 - Gao, Chuan
A1 - Girotto, Giorgia
A1 - Harris, Sarah E
A1 - He, Meian
A1 - Hsu, Fang-Chi
A1 - Kuhnel, Brigitte
A1 - Laguzzi, Federica
A1 - Li, Xiaoyin
A1 - Lyytikäinen, Leo-Pekka
A1 - Nolte, Ilja M
A1 - Poveda, Alaitz
A1 - Rauramaa, Rainer
A1 - Riaz, Muhammad
A1 - Rueedi, Rico
A1 - Shu, Xiao-Ou
A1 - Snieder, Harold
A1 - Sofer, Tamar
A1 - Takeuchi, Fumihiko
A1 - Verweij, Niek
A1 - Ware, Erin B
A1 - Weiss, Stefan
A1 - Yanek, Lisa R
A1 - Amin, Najaf
A1 - Arking, Dan E
A1 - Arnett, Donna K
A1 - Bergmann, Sven
A1 - Boerwinkle, Eric
A1 - Brody, Jennifer A
A1 - Broeckel, Ulrich
A1 - Brumat, Marco
A1 - Burke, Gregory
A1 - Cabrera, Claudia P
A1 - Canouil, Mickaël
A1 - Chee, Miao Li
A1 - Chen, Yii-Der Ida
A1 - Cocca, Massimiliano
A1 - Connell, John
A1 - de Silva, H Janaka
A1 - de Vries, Paul S
A1 - Eiriksdottir, Gudny
A1 - Faul, Jessica D
A1 - Fisher, Virginia
A1 - Forrester, Terrence
A1 - Fox, Ervin F
A1 - Friedlander, Yechiel
A1 - Gao, He
A1 - Gigante, Bruna
A1 - Giulianini, Franco
A1 - Gu, Chi Charles
A1 - Gu, Dongfeng
A1 - Harris, Tamara B
A1 - He, Jiang
A1 - Heikkinen, Sami
A1 - Heng, Chew-Kiat
A1 - Hunt, Steven
A1 - Ikram, M Arfan
A1 - Irvin, Marguerite R
A1 - Kähönen, Mika
A1 - Kavousi, Maryam
A1 - Khor, Chiea Chuen
A1 - Kilpeläinen, Tuomas O
A1 - Koh, Woon-Puay
A1 - Komulainen, Pirjo
A1 - Kraja, Aldi T
A1 - Krieger, J E
A1 - Langefeld, Carl D
A1 - Li, Yize
A1 - Liang, Jingjing
A1 - Liewald, David C M
A1 - Liu, Ching-Ti
A1 - Liu, Jianjun
A1 - Lohman, Kurt K
A1 - Mägi, Reedik
A1 - McKenzie, Colin A
A1 - Meitinger, Thomas
A1 - Metspalu, Andres
A1 - Milaneschi, Yuri
A1 - Milani, Lili
A1 - Mook-Kanamori, Dennis O
A1 - Nalls, Mike A
A1 - Nelson, Christopher P
A1 - Norris, Jill M
A1 - O'Connell, Jeff
A1 - Ogunniyi, Adesola
A1 - Padmanabhan, Sandosh
A1 - Palmer, Nicholette D
A1 - Pedersen, Nancy L
A1 - Perls, Thomas
A1 - Peters, Annette
A1 - Petersmann, Astrid
A1 - Peyser, Patricia A
A1 - Polasek, Ozren
A1 - Porteous, David J
A1 - Raffel, Leslie J
A1 - Rice, Treva K
A1 - Rotter, Jerome I
A1 - Rudan, Igor
A1 - Rueda-Ochoa, Oscar-Leonel
A1 - Sabanayagam, Charumathi
A1 - Salako, Babatunde L
A1 - Schreiner, Pamela J
A1 - Shikany, James M
A1 - Sidney, Stephen S
A1 - Sims, Mario
A1 - Sitlani, Colleen M
A1 - Smith, Jennifer A
A1 - Starr, John M
A1 - Strauch, Konstantin
A1 - Swertz, Morris A
A1 - Teumer, Alexander
A1 - Tham, Yih Chung
A1 - Uitterlinden, André G
A1 - Vaidya, Dhananjay
A1 - van der Ende, M Yldau
A1 - Waldenberger, Melanie
A1 - Wang, Lihua
A1 - Wang, Ya-Xing
A1 - Wei, Wen-Bin
A1 - Weir, David R
A1 - Wen, Wanqing
A1 - Yao, Jie
A1 - Yu, Bing
A1 - Yu, Caizheng
A1 - Yuan, Jian-Min
A1 - Zhao, Wei
A1 - Zonderman, Alan B
A1 - Becker, Diane M
A1 - Bowden, Donald W
A1 - Deary, Ian J
A1 - Dörr, Marcus
A1 - Esko, Tõnu
A1 - Freedman, Barry I
A1 - Froguel, Philippe
A1 - Gasparini, Paolo
A1 - Gieger, Christian
A1 - Jonas, Jost Bruno
A1 - Kammerer, Candace M
A1 - Kato, Norihiro
A1 - Lakka, Timo A
A1 - Leander, Karin
A1 - Lehtimäki, Terho
A1 - Magnusson, Patrik K E
A1 - Marques-Vidal, Pedro
A1 - Penninx, Brenda W J H
A1 - Samani, Nilesh J
A1 - van der Harst, Pim
A1 - Wagenknecht, Lynne E
A1 - Wu, Tangchun
A1 - Zheng, Wei
A1 - Zhu, Xiaofeng
A1 - Bouchard, Claude
A1 - Cooper, Richard S
A1 - Correa, Adolfo
A1 - Evans, Michele K
A1 - Gudnason, Vilmundur
A1 - Hayward, Caroline
A1 - Horta, Bernardo L
A1 - Kelly, Tanika N
A1 - Kritchevsky, Stephen B
A1 - Levy, Daniel
A1 - Palmas, Walter R
A1 - Pereira, A C
A1 - Province, Michael M
A1 - Psaty, Bruce M
A1 - Ridker, Paul M
A1 - Rotimi, Charles N
A1 - Tai, E Shyong
A1 - van Dam, Rob M
A1 - van Duijn, Cornelia M
A1 - Wong, Tien Yin
A1 - Rice, Kenneth
A1 - Gauderman, W James
A1 - Morrison, Alanna C
A1 - North, Kari E
A1 - Kardia, Sharon L R
A1 - Caulfield, Mark J
A1 - Elliott, Paul
A1 - Munroe, Patricia B
A1 - Franks, Paul W
A1 - Rao, Dabeeru C
A1 - Fornage, Myriam
AB - Educational attainment is widely used as a surrogate for socioeconomic status (SES). Low SES is a risk factor for hypertension and high blood pressure (BP). To identify novel BP loci, we performed multi-ancestry meta-analyses accounting for gene-educational attainment interactions using two variables, "Some College" (yes/no) and "Graduated College" (yes/no). Interactions were evaluated using both a 1 degree of freedom (DF) interaction term and a 2DF joint test of genetic and interaction effects. Analyses were performed for systolic BP, diastolic BP, mean arterial pressure, and pulse pressure. We pursued genome-wide interrogation in Stage 1 studies (N = 117 438) and follow-up on promising variants in Stage 2 studies (N = 293 787) in five ancestry groups. Through combined meta-analyses of Stages 1 and 2, we identified 84 known and 18 novel BP loci at genome-wide significance level (P < 5 × 10). Two novel loci were identified based on the 1DF test of interaction with educational attainment, while the remaining 16 loci were identified through the 2DF joint test of genetic and interaction effects. Ten novel loci were identified in individuals of African ancestry. Several novel loci show strong biological plausibility since they involve physiologic systems implicated in BP regulation. They include genes involved in the central nervous system-adrenal signaling axis (ZDHHC17, CADPS, PIK3C2G), vascular structure and function (GNB3, CDON), and renal function (HAS2 and HAS2-AS1, SLIT3). Collectively, these findings suggest a role of educational attainment or SES in further dissection of the genetic architecture of BP.

ER -