TY - JOUR
T1 - Mendelian randomization analysis does not support causal associations of birth weight with hypertension risk and blood pressure in adulthood.
JF - Eur J Epidemiol
Y1 - 2020
A1 - Zheng, Yan
A1 - Huang, Tao
A1 - Wang, Tiange
A1 - Mei, Zhendong
A1 - Sun, Zhonghan
A1 - Zhang, Tao
A1 - Ellervik, Christina
A1 - Chai, Jin-Fang
A1 - Sim, Xueling
A1 - van Dam, Rob M
A1 - Tai, E-Shyong
A1 - Koh, Woon-Puay
A1 - Dorajoo, Rajkumar
A1 - Saw, Seang-Mei
A1 - Sabanayagam, Charumathi
A1 - Wong, Tien Yin
A1 - Gupta, Preeti
A1 - Rossing, Peter
A1 - Ahluwalia, Tarunveer S
A1 - Vinding, Rebecca K
A1 - Bisgaard, Hans
A1 - Bønnelykke, Klaus
A1 - Wang, Yujie
A1 - Graff, Mariaelisa
A1 - Voortman, Trudy
A1 - van Rooij, Frank J A
A1 - Hofman, Albert
A1 - van Heemst, Diana
A1 - Noordam, Raymond
A1 - Estampador, Angela C
A1 - Varga, Tibor V
A1 - Enzenbach, Cornelia
A1 - Scholz, Markus
A1 - Thiery, Joachim
A1 - Burkhardt, Ralph
A1 - Orho-Melander, Marju
A1 - Schulz, Christina-Alexandra
A1 - Ericson, Ulrika
A1 - Sonestedt, Emily
A1 - Kubo, Michiaki
A1 - Akiyama, Masato
A1 - Zhou, Ang
A1 - Kilpeläinen, Tuomas O
A1 - Hansen, Torben
A1 - Kleber, Marcus E
A1 - Delgado, Graciela
A1 - McCarthy, Mark
A1 - Lemaitre, Rozenn N
A1 - Felix, Janine F
A1 - Jaddoe, Vincent W V
A1 - Wu, Ying
A1 - Mohlke, Karen L
A1 - Lehtimäki, Terho
A1 - Wang, Carol A
A1 - Pennell, Craig E
A1 - Schunkert, Heribert
A1 - Kessler, Thorsten
A1 - Zeng, Lingyao
A1 - Willenborg, Christina
A1 - Peters, Annette
A1 - Lieb, Wolfgang
A1 - Grote, Veit
A1 - Rzehak, Peter
A1 - Koletzko, Berthold
A1 - Erdmann, Jeanette
A1 - Munz, Matthias
A1 - Wu, Tangchun
A1 - He, Meian
A1 - Yu, Caizheng
A1 - Lecoeur, Cécile
A1 - Froguel, Philippe
A1 - Corella, Dolores
A1 - Moreno, Luis A
A1 - Lai, Chao-Qiang
A1 - Pitkänen, Niina
A1 - Boreham, Colin A
A1 - Ridker, Paul M
A1 - Rosendaal, Frits R
A1 - de Mutsert, Renée
A1 - Power, Chris
A1 - Paternoster, Lavinia
A1 - Sørensen, Thorkild I A
A1 - Tjønneland, Anne
A1 - Overvad, Kim
A1 - Djoussé, Luc
A1 - Rivadeneira, Fernando
A1 - Lee, Nanette R
A1 - Raitakari, Olli T
A1 - Kähönen, Mika
A1 - Viikari, Jorma
A1 - Langhendries, Jean-Paul
A1 - Escribano, Joaquin
A1 - Verduci, Elvira
A1 - Dedoussis, George
A1 - König, Inke
A1 - Balkau, Beverley
A1 - Coltell, Oscar
A1 - Dallongeville, Jean
A1 - Meirhaeghe, Aline
A1 - Amouyel, Philippe
A1 - Gottrand, Frédéric
A1 - Pahkala, Katja
A1 - Niinikoski, Harri
A1 - Hyppönen, Elina
A1 - März, Winfried
A1 - Mackey, David A
A1 - Gruszfeld, Dariusz
A1 - Tucker, Katherine L
A1 - Fumeron, Frédéric
A1 - Estruch, Ramon
A1 - Ordovas, Jose M
A1 - Arnett, Donna K
A1 - Mook-Kanamori, Dennis O
A1 - Mozaffarian, Dariush
A1 - Psaty, Bruce M
A1 - North, Kari E
A1 - Chasman, Daniel I
A1 - Qi, Lu
AB - Epidemiology studies suggested that low birthweight was associated with a higher risk of hypertension in later life. However, little is known about the causality of such associations. In our study, we evaluated the causal association of low birthweight with adulthood hypertension following a standard analytic protocol using the study-level data of 183,433 participants from 60 studies (CHARGE-BIG consortium), as well as that with blood pressure using publicly available summary-level genome-wide association data from EGG consortium of 153,781 participants, ICBP consortium and UK Biobank cohort together of 757,601 participants. We used seven SNPs as the instrumental variable in the study-level analysis and 47 SNPs in the summary-level analysis. In the study-level analyses, decreased birthweight was associated with a higher risk of hypertension in adults (the odds ratio per 1 standard deviation (SD) lower birthweight, 1.22; 95% CI 1.16 to 1.28), while no association was found between genetically instrumented birthweight and hypertension risk (instrumental odds ratio for causal effect per 1 SD lower birthweight, 0.97; 95% CI 0.68 to 1.41). Such results were consistent with that from the summary-level analyses, where the genetically determined low birthweight was not associated with blood pressure measurements either. One SD lower genetically determined birthweight was not associated with systolic blood pressure (β = - 0.76, 95% CI - 2.45 to 1.08 mmHg), 0.06 mmHg lower diastolic blood pressure (β = - 0.06, 95% CI - 0.93 to 0.87 mmHg), or pulse pressure (β = - 0.65, 95% CI - 1.38 to 0.69 mmHg, all p > 0.05). Our findings suggest that the inverse association of birthweight with hypertension risk from observational studies was not supported by large Mendelian randomization analyses.

VL - 35
IS - 7
ER -