TY - JOUR T1 - Mendelian randomization analysis does not support causal associations of birth weight with hypertension risk and blood pressure in adulthood. JF - Eur J Epidemiol Y1 - 2020 A1 - Zheng, Yan A1 - Huang, Tao A1 - Wang, Tiange A1 - Mei, Zhendong A1 - Sun, Zhonghan A1 - Zhang, Tao A1 - Ellervik, Christina A1 - Chai, Jin-Fang A1 - Sim, Xueling A1 - van Dam, Rob M A1 - Tai, E-Shyong A1 - Koh, Woon-Puay A1 - Dorajoo, Rajkumar A1 - Saw, Seang-Mei A1 - Sabanayagam, Charumathi A1 - Wong, Tien Yin A1 - Gupta, Preeti A1 - Rossing, Peter A1 - Ahluwalia, Tarunveer S A1 - Vinding, Rebecca K A1 - Bisgaard, Hans A1 - Bønnelykke, Klaus A1 - Wang, Yujie A1 - Graff, Mariaelisa A1 - Voortman, Trudy A1 - van Rooij, Frank J A A1 - Hofman, Albert A1 - van Heemst, Diana A1 - Noordam, Raymond A1 - Estampador, Angela C A1 - Varga, Tibor V A1 - Enzenbach, Cornelia A1 - Scholz, Markus A1 - Thiery, Joachim A1 - Burkhardt, Ralph A1 - Orho-Melander, Marju A1 - Schulz, Christina-Alexandra A1 - Ericson, Ulrika A1 - Sonestedt, Emily A1 - Kubo, Michiaki A1 - Akiyama, Masato A1 - Zhou, Ang A1 - Kilpeläinen, Tuomas O A1 - Hansen, Torben A1 - Kleber, Marcus E A1 - Delgado, Graciela A1 - McCarthy, Mark A1 - Lemaitre, Rozenn N A1 - Felix, Janine F A1 - Jaddoe, Vincent W V A1 - Wu, Ying A1 - Mohlke, Karen L A1 - Lehtimäki, Terho A1 - Wang, Carol A A1 - Pennell, Craig E A1 - Schunkert, Heribert A1 - Kessler, Thorsten A1 - Zeng, Lingyao A1 - Willenborg, Christina A1 - Peters, Annette A1 - Lieb, Wolfgang A1 - Grote, Veit A1 - Rzehak, Peter A1 - Koletzko, Berthold A1 - Erdmann, Jeanette A1 - Munz, Matthias A1 - Wu, Tangchun A1 - He, Meian A1 - Yu, Caizheng A1 - Lecoeur, Cécile A1 - Froguel, Philippe A1 - Corella, Dolores A1 - Moreno, Luis A A1 - Lai, Chao-Qiang A1 - Pitkänen, Niina A1 - Boreham, Colin A A1 - Ridker, Paul M A1 - Rosendaal, Frits R A1 - de Mutsert, Renée A1 - Power, Chris A1 - Paternoster, Lavinia A1 - Sørensen, Thorkild I A A1 - Tjønneland, Anne A1 - Overvad, Kim A1 - Djoussé, Luc A1 - Rivadeneira, Fernando A1 - Lee, Nanette R A1 - Raitakari, Olli T A1 - Kähönen, Mika A1 - Viikari, Jorma A1 - Langhendries, Jean-Paul A1 - Escribano, Joaquin A1 - Verduci, Elvira A1 - Dedoussis, George A1 - König, Inke A1 - Balkau, Beverley A1 - Coltell, Oscar A1 - Dallongeville, Jean A1 - Meirhaeghe, Aline A1 - Amouyel, Philippe A1 - Gottrand, Frédéric A1 - Pahkala, Katja A1 - Niinikoski, Harri A1 - Hyppönen, Elina A1 - März, Winfried A1 - Mackey, David A A1 - Gruszfeld, Dariusz A1 - Tucker, Katherine L A1 - Fumeron, Frédéric A1 - Estruch, Ramon A1 - Ordovas, Jose M A1 - Arnett, Donna K A1 - Mook-Kanamori, Dennis O A1 - Mozaffarian, Dariush A1 - Psaty, Bruce M A1 - North, Kari E A1 - Chasman, Daniel I A1 - Qi, Lu AB -

Epidemiology studies suggested that low birthweight was associated with a higher risk of hypertension in later life. However, little is known about the causality of such associations. In our study, we evaluated the causal association of low birthweight with adulthood hypertension following a standard analytic protocol using the study-level data of 183,433 participants from 60 studies (CHARGE-BIG consortium), as well as that with blood pressure using publicly available summary-level genome-wide association data from EGG consortium of 153,781 participants, ICBP consortium and UK Biobank cohort together of 757,601 participants. We used seven SNPs as the instrumental variable in the study-level analysis and 47 SNPs in the summary-level analysis. In the study-level analyses, decreased birthweight was associated with a higher risk of hypertension in adults (the odds ratio per 1 standard deviation (SD) lower birthweight, 1.22; 95% CI 1.16 to 1.28), while no association was found between genetically instrumented birthweight and hypertension risk (instrumental odds ratio for causal effect per 1 SD lower birthweight, 0.97; 95% CI 0.68 to 1.41). Such results were consistent with that from the summary-level analyses, where the genetically determined low birthweight was not associated with blood pressure measurements either. One SD lower genetically determined birthweight was not associated with systolic blood pressure (β = - 0.76, 95% CI - 2.45 to 1.08 mmHg), 0.06 mmHg lower diastolic blood pressure (β = - 0.06, 95% CI - 0.93 to 0.87 mmHg), or pulse pressure (β = - 0.65, 95% CI - 1.38 to 0.69 mmHg, all p > 0.05). Our findings suggest that the inverse association of birthweight with hypertension risk from observational studies was not supported by large Mendelian randomization analyses.

VL - 35 IS - 7 ER -